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    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Produkt Beschreibung

    Apigenin Struktur
    520-36-5
    CAS-Nr.
    520-36-5
    Bezeichnung:
    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron
    Englisch Name:
    Apigenin
    Synonyma:
    Apig;75580;75590;apigenol;Apegenin;UCCF 031;APIGENIN;Versulin;apigenine;Versuline
    CBNumber:
    CB1384541
    Summenformel:
    C15H10O5
    Molgewicht:
    270.24
    MOL-Datei:
    520-36-5.mol

    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Eigenschaften

    Schmelzpunkt:
    >300 °C (lit.)
    Siedepunkt:
    333.35°C (rough estimate)
    Dichte
    1.2319 (rough estimate)
    Brechungsindex
    1.6000 (estimate)
    storage temp. 
    2-8°C
    L?slichkeit
    DMSO: 27 mg/mL
    Aggregatzustand
    powder
    pka
    6.53±0.40(Predicted)
    Farbe
    yellow
    Merck 
    14,730
    BRN 
    262620
    InChIKey
    KZNIFHPLKGYRTM-UHFFFAOYSA-N
    CAS Datenbank
    520-36-5(CAS DataBase Reference)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xi
    R-S?tze: 36/37/38
    S-S?tze: 26-36
    WGK Germany  3
    RTECS-Nr. LK9276000
    10
    HS Code  29329985
    Giftige Stoffe Daten 520-36-5(Hazardous Substances Data)
    Bildanzeige (GHS)
    Alarmwort Warnung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
    H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
    H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
    Sicherheit
    P261 Einatmen von Staub vermeiden.
    P264 Nach Gebrauch gründlich waschen.
    P264 Nach Gebrauch gründlich waschen.
    P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
    P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
    P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
    P405 Unter Verschluss aufbewahren.

    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

    S-S?tze Betriebsanweisung:

    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

    Chemische Eigenschaften

    Pale Yellow Crystalline Solid

    Occurrence

    Chamomile is a perennial found in Europe.

    Verwenden

    antispasmodic, antineoplastic, topoisomerase I inhibitor

    Verwenden

    Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tum or cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.

    Verwenden

    Has been used to dye Cr mordanted wool yellow. The color is fast to soap.

    Allgemeine Beschreibung

    The herb known as chamomile is derived from the plants Matricaria chamomilla (German, Hungarian, or genuine chamomile) and Anthemis nobilis (English, Roman, or common chamomile). Plants from the two genera have similar activities. The medicinal components are obtained from the flowering tops. The flowers are dried and used for chamomile teas and extracts. Chamomile has been used medicinally for at least 2,000 years. The Romans used the herb for its medicinal properties, which they knew were antispasmodic and sedative.
    The herb also has a long history in the treatment of digestive and rheumatic disorders. The activity of chamomile is found in a light blue essential oil that composes only 0.5% of the flower. The blue color is caused by chamazulene, 7-ethyl-1,4-dimethylazulene . This compound is actually a byproduct of processing the herb. The major component of the oil is the sesquiterpene (-)-α-bisabolol. Also present are apigenin, angelic acid, tiglic acid, the terpene precursors (farnesol, nerolidol, and germacranolide) coumarin, scopoletin-7-glucoside, umbelliferone, and herniarin. Much of the effect of chamomile is caused by bisabolol . Bisabolol is a highly active anti-inflammatory agent in various rodent inflammation and arthritis tests.

    Biologische Aktivit?t

    Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC 50 values are 59.44 and 31.15 μ M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo .

    Biochem/physiol Actions

    A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

    Anticancer Research

    It is a flavone compound found in many fruits and vegetables and abundant in chamomiletea, parsley, celeriac, and celery. It induces apoptosis by targeting leptin/leptin receptor pathway and by targeting caspase-dependent extrinsic pathway aswell as STAT3 signaling pathway in lung adenocarcinoma and BT-474 breast cancercells, respectively (Singh et al. 2016b). It shows antitumor activity against breastcancer MCF-7 cells and colon cancer HCT 116 cells and is a mediator of cancerchemoprevention and an inducer of autophagy. It can be used to treat colon canceras it induces apoptosis in colon cancer cells. It also increase melanogenesis in B16cells by activating the p38 MAPK pathway (Wang et al. 2012).

    l?uterung methode

    Crystallise it from aqueous pyridine or aqueous EtOH. It dyes wool yellow when mixed with Cr ions. [Beilstein 18 H 181, 18 I 396, 18 II 178, 18 III/IV 2682, 18/4 V 574.]

    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 509)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
    Xi'an Kono chem co., Ltd.,
    13289246953 029-86107037
    info@konochemical.com CHINA 3000 58
    Shaanxi Pioneer Biotech Co., Ltd .
    86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
    029-84385017 sales@pioneerbiotech.com CHINA 3001 58
    Aktin Chemicals, Inc.
    028-85159085
    86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
    Sinoway Industrial co., ltd.
    13806035118
    0592-5854960 xie@china-sinoway.com CHINA 311 58
    Capot Chemical Co.,Ltd.
    +86(0)13336195806 +86-571-85586718
    +86-571-85864795 sales@capotchem.com China 20012 60
    Henan DaKen Chemical CO.,LTD.
    +86-371-66670886
    info@dakenchem.com China 15426 58
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com China 22607 55
    Hangzhou FandaChem Co.,Ltd.
    008615858145714
    +86-571-56059825 fandachem@gmail.com CHINA 9143 55
    Nanjing Finetech Chemical Co., Ltd.
    025-85710122 17714198479
    025-85710122 sales@fine-chemtech.com CHINA 890 55
    ATK CHEMICAL COMPANY LIMITED
    +86 21 5161 9050/ 5187 7795
    +86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60

    520-36-5(5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron)Verwandte Suche:


    • 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
    • 4,5,7-Trihydroxyflavone (apigenin)
    • APIGENIN CRYSTALLINE
    • APIGENIN FROM PARSLEY
    • Matricaria chamomilla flower
    • Versuline
    • Pelargidenon 1449
    • 4’,5,7-trihydroxyflavaone
    • 4’,5,7-trihydroxy-flavon
    • 5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
    • apigenine
    • apigenol
    • c.i.naturalyellow1
    • Apigenin (30 mg)
    • LY 080400
    • Pelargidenone
    • Apegenin
    • NSC 83244
    • UCCF 031
    • APIGENIN >= 95.0% (HPLC)
    • 4',5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
    • Chinese Taxillus Herb
    • Apigenin/Celery seed extract
    • Chinese Taxillus Herb Extract
    • 4',5,7-Trihydroxyflavone 5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on 5,7,4'-Trihydroxyflavone
    • APIGENIN
    • CHAMOMILE
    • 4',5,7-TRIHYDROXYFLAVONE
    • 4,5,7-TRIHYDROXYFLAVONE
    • 4',5,7-TRIHYROXYFLAVONE
    • 5,7,4'-TRIHYDROXYFLAVONE
    • 5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
    • 7,4',5-TRIHYDROXYFLAVONE
    • APIGENIN / 4'',5,7-TRIHYDROXYFLAVONE
    • 2-(p-hydroxyphenyl)-5,7-dihydroxychromone
    • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-
    • 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
    • APIGENIN(P)
    • APIGENIN WITH HPLC
    • APIGENIN hplc
    • 4H-1-Benzopyran-4-one,5,7-dihydroxy-2-
    • Versulin
    • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
    • APIGENIN(RG)(PLEASE CALL)
    • Chinese Taxillus Twing
    • 75580
    • 75590
    • Nano Liposomal Apigenin
    • AS CUSTOMERS' REQUIREMENTS
    • Mulberry parasitic extract
    • 7-hydroxy-2-(4-hydroxyphenyl)-4-oxo-1-benzopyran-5-olate
    • Apigenin 520-36-5
    • Apigenin, ≥95% (HPLC)
    • Apigenin, ≥97% (HPLC)
    • Apigenin, ≥98.0% (HPLC)
    • Apigenin - CAS 520-36-5 - Calbiochem
    • Apigenin/ 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
    • Apigenin 97+%
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