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    Parathion-methyl (ISO) Produkt Beschreibung

    Parathion-methyl Struktur
    298-00-0
    CAS-Nr.
    298-00-0
    Bezeichnung:
    Parathion-methyl (ISO)
    Englisch Name:
    Parathion-methyl
    Synonyma:
    DALF;e601;a-gro;ME605;Dalif;NITRAN;MPT(R);8056HC;Azofos;Fulkil
    CBNumber:
    CB3348228
    Summenformel:
    C8H10NO5PS
    Molgewicht:
    263.21
    MOL-Datei:
    298-00-0.mol

    Parathion-methyl (ISO) Eigenschaften

    Schmelzpunkt:
    36°C
    Siedepunkt:
    143°C (1.0 mmHg)
    Dichte
    1.36
    Dampfdruck
    4.1×10-4 Pa (20 °C)
    Brechungsindex
    nD25 1.5367
    Flammpunkt:
    46.1°C
    storage temp. 
    APPROX 4°C
    Aggregatzustand
    solid
    Wasserl?slichkeit
    0.005 g/100 mL
    BRN 
    8905814
    Stabilit?t:
    Stable. Flammable.
    CAS Datenbank
    298-00-0(CAS DataBase Reference)
    IARC
    3 (Vol. 30, Sup 7) 1987
    NIST chemische Informationen
    Phosphorothioic acid, o,o-dimethyl-o-p-nitrophenyl ester(298-00-0)
    EPA chemische Informationen
    Methyl parathion (298-00-0)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher T+;N,N,T+,Xn,F
    R-S?tze: 5-24-26/28-48/22-50/53-10-67-66-51/53-36-20/22-11-65-38
    S-S?tze: 28-36/37-45-60-61-26-62-16
    RIDADR  UN 2052/2783/2811
    WGK Germany  3
    RTECS-Nr. TG0175000
    HazardClass  6.1(a)
    PackingGroup  II
    HS Code  29201100
    Giftige Stoffe Daten 298-00-0(Hazardous Substances Data)
    Toxizit?t LD50 in male, female rats (mg/kg): 14, 24 orally; 67, 67 dermally (Gaines)
    Bildanzeige (GHS)
    Alarmwort Achtung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
    H226 Flüssigkeit und Dampf entzündbar. Entzündbare Flüssigkeiten Kategorie 3 Warnung
    H304 Kann bei Verschlucken und Eindringen in die Atemwege t?dlich sein. Aspirationsgefahr Kategorie 1 Achtung
    H311 Giftig bei Hautkontakt. Akute Toxizit?t dermal Kategorie 3 Achtung P280, P302+P352, P312, P322, P361,P363, P405, P501
    H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
    H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
    H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
    H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
    H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung P273, P391, P501
    H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 2
    Sicherheit
    P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
    P261 Einatmen von Staub vermeiden.
    P273 Freisetzung in die Umwelt vermeiden.
    P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
    P391 Verschüttete Mengen aufnehmen.
    P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
    P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
    P370+P378 Bei Brand: zum L?schen verwenden.

    Parathion-methyl (ISO) Chemische Eigenschaften,Einsatz,Produktion Methoden

    ERSCHEINUNGSBILD

    FARBLOSER BIS WEISSER FESTSTOFF IN VERSCHIEDENEN FORMEN.

    CHEMISCHE GEFAHREN

    Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Stickstoffoxiden, Phosphoroxiden oder Schwefeloxiden. Feuer- und Explosionsgefahr.

    ARBEITSPLATZGRENZWERTE

    TLV: 0.2 mg/m?(als TWA); Hautresorption; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); BEI vorhanden; (ACGIH 2005).
    MAK nicht festgelegt (DFG 2005).

    AUFNAHMEWEGE

    Aufnahme in den K?rper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.

    INHALATIONSGEFAHREN

    Eine gesundheitssch?dliche Partikelkonzentration in der Luft kann beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

    WIRKUNGEN BEI KURZZEITEXPOSITION

    WIRKUNGEN BEI KURZZEITEXPOSITION:
    M?glich sind Auswirkungen auf das Nervensystem mit nachfolgenden Kr?mpfen und Atemdepression. Cholinesterasehemmer. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann zum Tod führen. ?rztliche Beobachtung notwendig.

    WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

    Cholinesterasehemmer. Kumulative Wirkung m?glich (s. AKUTE GEFAHREN/SYMPTOME).

    LECKAGE

    Pers?nliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabh?ngigem Atemschutzger?t. NICHT in die Umwelt gelangen lassen. Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgf?ltig sammeln. An sicheren Ort bringen.

    R-S?tze Betriebsanweisung:

    R5:Beim Erw?rmen explosionsf?hig.
    R24:Giftig bei Berührung mit der Haut.
    R26/28:Sehr giftig beim Einatmen und Verschlucken.
    R48/22:Gesundheitssch?dlich: Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition durch Verschlucken.
    R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
    R10:Entzündlich.
    R67:D?mpfe k?nnen Schl?frigkeit und Benommenheit verursachen.
    R66:Wiederholter Kontakt kann zu spr?der oder rissiger Haut führen.
    R51/53:Giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
    R36:Reizt die Augen.
    R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
    R11:Leichtentzündlich.
    R65:Gesundheitssch?dlich: kann beim Verschlucken Lungensch?den verursachen.
    R38:Reizt die Haut.

    S-S?tze Betriebsanweisung:

    S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
    S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
    S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ?rztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.

    Beschreibung

    A case of sensitization to parathion methyl was described in a female agricultural worker with multiple sensitization.

    Beschreibung

    Methyl parathion is an organophosphate insecticide. It is converted into an oxon-containing metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase. Methyl parathion is lethal to lab strains and field isolates of tobacco budworm larvae (LD50s = 7 and 81.8-128.3 μg/g, respectively). It reduces the number of stink bugs (C. sayi) caught per 100 net sweeps when applied to alfalfa fields at a concentration of 0.4 pounds per acre. Methyl parathion increases sister chromatid exchange (SCE) in a concentration-dependent manner and induces cell cycle arrest at the M1 phase in V79 cells at a concentration of 40 μg/ml. It is toxic to rats (LD50 = 14 mg/kg).

    Chemische Eigenschaften

    Methyl parathion is a white to yellow-brown, crystalline solid with a garlic odor.It is slightly soluble in water and has a low vapor pressure (U.S. EPA, 2006b).

    Verwenden

    Parathion-methyl is an derivative of Parathion (P192220), an organophosphate insecticide used on cotton, rice and fruit trees.

    Verwenden

    Methyl parathion is an insecticide and acaricide used to control boll weevils and many biting or sucking insect pests of agricultural crops. It kills insects by contact, stomach and respiratory action. Methyl parathion is available in dust, emulsifiable concentrate, ULV liquid, microencapsules and wettable powder formulations.
    Methyl parathion is one of a class of insecticides referred to as organophosphates. These chemicals act by interfering with the activities of cholinesterase, an enzyme that is essential for the proper working of the nervous systems of humans, animals and insects.

    Verwenden

    Methyl parathion is a restricted use organophosphate sold under a number of trade names and formulations. First registered in 1954, it is used to control a variety of insect pests on food and feed crops. Methyl parathion is not used in residential settings due to its toxicity to humans, birds, and honey bees. The chemical is a restricted use pesticide with nearly 4 million pounds of active ingredient mainly used on cotton, corn, wheat, soybeans, and rice (U.S. EPA, 2006b).

    Definition

    ChEBI: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.

    Allgemeine Beschreibung

    Methyl parathion is a white crystalline solid dissolved in a liquid solvent carrier. The commercial product is a tan liquid (xylene solution) with a pungent odor. Parathion-methyl is slightly soluble to insoluble in water. Usually with the liquid solvent Parathion-methyl is a combustible liquid. Parathion-methyl is toxic by inhalation, ingestion and skin absorption. Parathion-methyl is used as an insecticide.

    Air & Water Reaktionen

    Insoluble in water.

    Reaktivit?t anzeigen

    METHYL PARATHION is half decomposed in 8 days at 40°C. When a sample was heated in a small test tube Parathion-methyl decomposed in a few minutes, the residue exploded (Food Chem. 4(1):42. 1956).

    Hazard

    Explosion risk when heated. Toxicby skin absorption, inhalation, and ingestion;cholinesterase inhibitor. Use has been restricted.Questionable carcinogen.

    Health Hazard

    Parathion-methyl is extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. Chronic toxicity does not appear to be a major consideration.

    Brandgefahr

    Poisonous gases are produced in fire and when heated. Decomposition may lead to sufficient internal pressure to cause the container to rupture violently. Avoid oxidizing materials. Unstable. High temperatures (120F) cause decomposition.

    Landwirtschaftliche Anwendung

    Insecticide, Nematicide: A U.S. EPA restricted Use Pesticide (RUP). Severely Restricted for use in EU, as parathion-methyl. This material is used as an insecticide on over 50 crops, primarily cotton, but also on walnuts, corn, dried beans and almonds and on several ornamentals. It is no longer allowed to be used on crops consumed by children.

    Handelsname

    A-GRO®[C]; AI3-17292®; ATOMIC®[C]; AZOFOS®; AZOPHOS; BAMA BRAND®[C]; BAY 11405®; BAY E-601®; BLADAN M®; CEKUMETHION®; CLEAN CROP®[C]; COTTON TOX DUST®[C]; DALF®; DECLARE®; DEVITHION®; DREXEL METHYL PARATHION 4E®[C]; DURHAM[C]; E 601®; EMMY®[C]; E-Z-FLO®[C]; FALL OUT®[C]; FMC NYNAMITE®[C]; FOLIDOC®; FOLIDOL-80®; FOLIDOL M®; FOLIDOL M-40®; FOSFERNO M 50®; GEARPHOS®; 8056HC®; KILEX PARATHION®; ME-PARATHION®; MEPTOX®; METACID 50®; METACIDE®; METAFOS®; METAPHOS®; METRON®; METHYL-E 605®; METRON®; NITROX®; NITROX® 80; OLEOVOFOTOX®; PARAPEST M-50®; PENNCAP M®; PENNCAP MLS®; QUINOPHOS®; SEIS-TRES 6-3®; SINAFID M-48®; SIXTY-THREE SPECIAL E. C. INSECTICIDE®; TEKWAISA®; THIOPHENIT®; THYLPAR M-50®; TOLL®; VERTAC METHYL PARATHION TECHNISCH 80%®; WOFATOX 50 EC®

    Kontakt-Allergie

    A case of sensitization to methyl-parathion was described in a female agricultural worker with multiple sensitization.

    Sicherheitsprofil

    Poison by inhalation, ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. Fatal poisoning can result from skin or eye contact after very brief exposure to concentrated solution. Experimental teratogenic and reproductive effects. Questionable carcinogen. Human mutation data reported. A cholinesterase inhibitor type of insecticide. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.

    m?gliche Exposition

    A severely hazardous pesticide formulation. Alert: This material is used as an insecticide on over 50 crops, primarily cotton, and on several ornamentals

    Carcinogenicity

    When rats were given diets with 0, 0.5, 2.5, 12.5, and 50 ppm (0, 0.02, 0.1, 0.5, or 2 mg/kg/day (males); 0, 0.02, 0.1, 0.7, or 3 mg/kg/day (females) for 12 months, neuronal degeneration and plasma, erythrocyte, and brain cholinesterase inhibition occurred at 12.5 and 50 ppm .

    Environmental Fate

    Methyl parathion is mobile in soils and can leach into groundwater and enter surface water as runoff. The chemical breaks down though microbial degradation, aqueous photolysis, hydrolysis, and incorporation into soil organic matter; thus, it degrades rapidly in soil and water with a half-life <5 days. Photodegradation is rapid in aquatic environments with a half-life of 49 h. Bioconcentration is not expected to occur (U.S. EPA, 2006b).

    Stoffwechselwegen

    Parathion-methyl is a non-systemic insecticide and, where studied, metabolism parallels that of parathion and f enitrothion. The major routes of biotransformation involve desulfuration to the oxon analogue (paraoxon-methyl) and hydrolysis to give dimethyl phosphate, dimethyl phosphorothionate and 4-nitrophenol. Demethylation to give desmethylparathion- methyl and reduction of the nitro group also occurs. As with organophosphates, demethylation via glutathione-S-methyl transferases in the liver and some other tissues is an important mechanism in mammals. The major route of phase II metabolism involves conjugation of 4-nitrophenol followed by excretion.

    Versand/Shipping

    UN3017 Organophosphorus pesticides, liquid, toxic, flammable, flash point not ,23C, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3.-Flammable liquid. UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous material. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required

    Degradation

    Parathion-methyl (1) is hydrolysed under acidic and alkaline conditions. The rate is five times faster than for parathion. Upon heating it isomerises via a thonwthiolo rearrangement to yield S-methylparahon-methyl (2) (PM). The hydrolysis of the active anticholinesterase oxon analogue (paraoxon-methyl) (3) is much faster than that of parathion-methyl. The products of parathion-methyl hydrolysis were 4-nitrophenol (4) and dimethyl phosphorothioate (5) (Thuma et al., 1983). Hydrolysis is much more rapid in alkaline than in acidic or neutral media. Photodegradation in natural sunlight led to the formation of O,O,S-trimethyl phosphorothioate (6) and trimethyl phosphate (7) (Chukwudebe et al., 1989). Zweiner et al. (1994) examined the photolysis of parathion-methyl in aqueous solution after irradiation by unfiltered UV light. The major metabolites, which were detected by GC-MS, were paraoxon-methyl (3) and 4-nitrophenol (4). These conversions are shown in Scheme 1.

    Inkompatibilit?ten

    Incompatible with oxidizers, strong bases; heat. Mixtures with magnesium, or endrin may be violent or explosive. Slightly decomposed by acid solutions. Rapidly decomposed by alkalies. Explosive risk when heated above 50C. The liquid xylene solution decomposes violently @ 120C

    Waste disposal

    Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration (816C, 0.5 second minimum for primary combustion; 1204C, 1.0 second for secondary combustion) with adequate scrubbing and ash disposal facilities. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

    Parathion-methyl (ISO) Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Parathion-methyl (ISO) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 0)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate

    298-00-0(Parathion-methyl (ISO))Verwandte Suche:


    • NITROX 80(R)
    • NITRAN
    • O,O-DIMETHYL O-(4-NITROPHENYL)-PHOSPHOROTHIOATE
    • O,O-DIMETHYL-O-P-NITROPHENYL PHOSPHOROTHIOATE(R)
    • O,O-Dimethyl O-(p-nitrophenyl) thionophosphate
    • PARASHOOT(R)
    • PARATHION-METHYL
    • PARTON(R)
    • PARIDOL(R)
    • MPT(R)
    • oleovofotox
    • OMS 213
    • parapestm-50
    • Parataf
    • Parathion methyl homolog
    • parathionmethylhomolog
    • parathion-metile
    • Paratox
    • parton-m
    • Partron M
    • partronm
    • Pencap M
    • Penncap M
    • PhosphorothioicacidO,O-dimethylO-(4-nitro-phenyl)esenyl)ester
    • phosphorothioicacido,o-dimethylo-(4-nitrophenyl)ester
    • p-nitrophenyldimethylthionophosphate
    • quinophos
    • rcrawastenumberp071
    • Sinafid M-48
    • sinafidm-48
    • Methyl Parathion? Methyl parathion, liquid
    • O,O-Dimethyl-O-(4-nitrophenyl)-phosphate (total dust)
    • O,O-Dimethyl-O-(4-nitrophenyl)-phosphate (total respirable dust)
    • parathion - methyl (ISO) O,O-dimethyl O-4-nitrophenyl phosphorothioate
    • Methyl parathion, O,O-Dimethyl O-(4-nitrophenyl) phosphorothioate
    • METHLY PARATHION
    • METHYL PARATHION, 500MG, NEAT
    • METHYL PARATHION, 250MG, NEAT
    • PARATHION-METHYL PESTANAL
    • methylparathion (esa,jmaf)
    • parathion-methyl solution
    • parathion-methyl(bsi,iso)
    • PHOSPHOROTHIOICACID,ORTHO,ORTHO-DIMETHYL-ORTHO(PARA-NITROPHENYL)ESTER
    • DIMETHYLO-4-NITROPHENYLPHOSPHOROTHIOATE
    • O,O-DIMETHYL-O-PARA-NITROPHENYLTHIOPHOSPHATE
    • Methyl parathion solution
    • METHYL PARATHION
    • METRON(R)
    • METACIDE
    • METACIDE(R)
    • CEKUMETHION
    • DALF(R)
    • DANACAP(R)
    • E601(R)
    • DIMETHYL PARATHION
    • FOLIDOL-M
    • FOLIDOL-M(R)
    • 8056HC
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