• ChemicalBook
    Chinese english Germany Japanese Korea

    Hexobendindihydrochlorid Produkt Beschreibung

    hexobendine dihydrochloride  Struktur
    50-62-4
    CAS-Nr.
    50-62-4
    Bezeichnung:
    Hexobendindihydrochlorid
    Englisch Name:
    hexobendine dihydrochloride
    Synonyma:
    Reoxyl;Ustimon;Andiamine;Hexobendin Hydrochloride;HEXOBENDINEHYDROCHLORIDE;hexobendine dihydrochloride;Hexobendine-d18 Dihydrochloride;3,3'-[Ethylenebis(MethyliMino)]di-1-propanol Bis(3,4,5-triMethoxybenzoate) (Ester) Dihydrochloride;3,4,5-TriMethoxybenzoic Acid 1,2-Ethanediylbis[(MethyliMino)-3,1-propanediyl] Ester Dihydrochloride;3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate dihydrochloride
    CBNumber:
    CB4939117
    Summenformel:
    C30H44N2O10.2ClH
    Molgewicht:
    665.603
    MOL-Datei:
    50-62-4.mol

    Hexobendindihydrochlorid Eigenschaften

    Schmelzpunkt:
    170-174°

    Sicherheit

    Hexobendindihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

    Originator

    Reoxyl,Hormonchemie,W. Germany,1966

    Verwenden

    Hexobendine dihydrochloride is used as vasodilator (coronary).

    Manufacturing Process

    Methylacrylate and N,N'-dimethylethylenediamine are first reacted and that product reduced with lithium aluminum hydride to give a compound A.
    To a solution of 13 parts of compound A and 12 parts by volume of absolute pyridine in 80 parts by volume of absolute dioxane there are added dropwise and under constant stirring 35 parts of 3,4,5-trimethoxybenzoyl chloride dissolved in 70 parts by volume of absolute dioxane in the course of 30 minutes. The mixture is stirred for a further 3 hours at a temperature of 100°C and the excess solvent is then evaporated in vacuo. The residue of the evaporation is treated with ethyl acetate and saturated sodium carbonate solution, whereafter the organic phase is separated, treated with water, dried with sodium sulfate and the solvent is removed in vacuo. The residue thus obtained is taken up in ether and separated from 4 parts of insoluble trimethoxybenzoic acid anhydride by filtration. After evaporation of the ether there are obtained 32.5 parts of N,N'-dimethyl-N,N'-bis-[3-(3,4,5- trimethoxybenzoxy)propyl]-ethylene diamine, corresponding to a yield of 86% of the theoretical. MP: 75°C to 77°C.
    The di-tertiary base thus obtained is dissolved in ether and the solution is saturated with hydrogen chloride gas. After isolation and reprecipitation from methanol-ether there is obtained the dihydrochloride melting at 170°C to 174°C.

    Therapeutic Function

    Vasodilator

    Hexobendindihydrochlorid Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Hexobendindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 7)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
    J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
    86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
    Chemsky (shanghai) International Co.,Ltd 021-50135380
    shchemsky@sina.com China 15424 60
    Shenzhen Polymeri Biochemical Technology Co., Ltd. 400-002-6226
    sales@biochemall.cn China 54467 58
    Energy Chemical 400-005-6266 021-58432009-
    021-58436166 marketing@energy-chemical.com China 44747 58

    • hexobendine dihydrochloride
    • Andiamine
    • Ustimon
    • HEXOBENDINEHYDROCHLORIDE
    • Reoxyl
    • 3,4,5-trimethoxybenzoic acid 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl ester dihydrochloride
    • 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate dihydrochloride
    • 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxyphenyl)carbonyloxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate dihydrochloride
    • 3,3'-[Ethylenebis(MethyliMino)]di-1-propanol Bis(3,4,5-triMethoxybenzoate) (Ester) Dihydrochloride
    • 3,4,5-TriMethoxybenzoic Acid 1,2-Ethanediylbis[(MethyliMino)-3,1-propanediyl] Ester Dihydrochloride
    • Hexobendin Hydrochloride
    • Hexobendine-d18 Dihydrochloride
    • 50-62-4
    • Amines
    • Aromatics
    • Intermediates & Fine Chemicals
    • Pharmaceuticals
    Copyright 2019 ? ChemicalBook. All rights reserved