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    Folsure Produkt Beschreibung

    Folic acid Struktur
    59-30-3
    CAS-Nr.
    59-30-3
    Bezeichnung:
    Folsure
    Englisch Name:
    Folic acid
    Synonyma:
    PGA;Folan;folic;Aspol;PTEGLU;FOLSAN;Folate;Folbal;Folsav;VM/PGA
    CBNumber:
    CB5100903
    Summenformel:
    C19H19N7O6
    Molgewicht:
    441.4
    MOL-Datei:
    59-30-3.mol

    Folsure Eigenschaften

    Schmelzpunkt:
    250 °C
    alpha 
    20 º (c=1, 0.1N NaOH)
    Siedepunkt:
    552.35°C (rough estimate)
    Dichte
    1.4704 (rough estimate)
    Brechungsindex
    1.6800 (estimate)
    storage temp. 
    2-8°C
    L?slichkeit
    boiling water: soluble1%
    pka
    pKa 2.5 (Uncertain)
    Aggregatzustand
    Crystalline Powder
    Farbe
    Yellow to orange
    Geruch (Odor)
    Odorless
    S?ure-Base-Indikators(pH-Indikatoren)
    4
    Wasserl?slichkeit
    1.6 mg/L (25 ºC)
    Merck 
    14,4221
    BRN 
    100781
    Stabilit?t:
    Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
    InChIKey
    OVBPIULPVIDEAO-LBPRGKRZSA-N
    CAS Datenbank
    59-30-3(CAS DataBase Reference)
    NIST chemische Informationen
    Folic acid(59-30-3)
    EPA chemische Informationen
    L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    R-S?tze: 33-62-68
    S-S?tze: 24/25
    WGK Germany  1
    RTECS-Nr. LP5425000
    8
    TSCA  Yes
    HS Code  29362900
    Giftige Stoffe Daten 59-30-3(Hazardous Substances Data)
    Bildanzeige (GHS)
    Alarmwort Warnung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
    H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
    H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
    Sicherheit
    P261 Einatmen von Staub vermeiden.
    P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

    Folsure Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R33:Gefahr kumulativer Wirkungen.
    R62:Kann m?glicherweise die Fortpflanzungsf?higkeit beeintr?chtigen.
    R68:Irreversibler Schaden m?glich.

    S-S?tze Betriebsanweisung:

    S24/25:Berührung mit den Augen und der Haut vermeiden.

    Beschreibung

    In the 1930s, brewer’s yeast was found to prevent anemia. Folic acid was later discovered to be the nutrient responsible for this effect and was purified in 1941 by Mitchell and coworkers (Mitchell et al., 1941). Folate is needed for biosynthesis of purines and thymidine for DNA and RNA synthesis in all cells. It is also involved in metabolism of some of the amino acids needed for protein synthesis, especially the conversions of serine to glycine and homocysteine to methionine. This makes the nutrient especially important during periods of rapid cell division, such as in pregnancy. Folate is also involved in transfer of one-carbon groups for methylation reactions. The role of folate in cell division was capitalized upon in the synthesis of aminopterin, a folate antagonist, which was one of the first anticancer drugs produced.

    Chemische Eigenschaften

    orange to yellow crystalline powder

    Physikalische Eigenschaften

    The folates include a large number of chemically related species, each differing with respect to the various substituents possible at three sites on the pteroylglutamic acid basic structure. More than 170 different folates are theoretically possible. Not all of these occur in nature; but it has been estimated that as many as 100 different forms are found in animals. The folates from most natural sources usually have a single carbon unit at N-5 and/or N-10; these forms participate in the metabolism of the single-carbon pool.
    Folic acid (pteroylmonoglutamic acid) is an orange-yellow crystalline substance that is soluble in water but insoluble in ethanol or less polar organic solvents. It is unstable to light, to acidic or alkaline conditions, to reducing agents, and, except in dry form, to heat. It is reduced in vivo enzymatically (or in vitro with a reductant such as dithionite) first to 7,8-dihydrofolic acid (FH2) and then to FH4; both of these compounds are unstable in aerobic environments and must be protected by the pres ence of an antioxidant (e.g., ascorbic acid, 2-mer
    Two derivatives of folic acid, each having an amino group in the place of the hydroxyl at C-4, are folate antagonists of biomedical use: aminopterin (4-aminofolic acid) and methotrexate (4-amino-N10-methylfolic acid). Aminopterin is used as a rodenticide; methotrexate is an antineoplastic agent.

    Originator

    Folvite, Lederle, US ,1946

    Occurrence

    Synthetic

    Verwenden

    folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.

    Verwenden

    Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.

    Verwenden

    Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.

    Verwenden

    A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

    Verwenden

    hematopoietic vitamin

    Definition

    ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

    Manufacturing Process

    The following description is taken from US Patent 2,956,057.
    100 grams of 1,3,3-trichloroacetone are heated on a boiling water bath and 95 grams of bromine are added thereto in drops while being stirred and the stirring is continued for about 1 hour. The resulting reaction solution is distilled under reduced pressure. 115 grams of 1-bromo-1,3,3- trichloroacetone are obtained having a boiling point of 85° to 95°C/17 mm (Hg).
    For the preparation of the hydrate, 100 grams of water are added to 100 grams of 1bromo-1,3,3-trichloroacetone, which is agitated and cooled. A white scaly crystal of hydrate of 1-bromo-1,3,3-trichloroacetone is obtained (100 grams), having a melting point of 52° to 53°C.
    8.9 grams of 2,4,5-triamino-6-hydroxypyrimidine hydrochloride and 8 grams of p-aminobenzoylglutamic acid are dissolved in 400 cc warm water, which is cooled at 35° to 27°C and adjusted to pH 4 by using 20% caustic soda solution. To this solution was simultaneously added dropwise a solution obtained by dissolving 13.4 grams of 1-bromo-1,3,3-trichloroacetone hydrate in 90 cc of 50% methanol and 24 grams of 35% aqueous sodium bisulfite solution over a period of approximately 2 hours. During this period, in order to maintain the pH value of the reaction solution at 4 to 5, 20% caustic soda solution is added from time to time. The precipitate, formed by stirring for 5 hours after dropping was finished, is filtered, and the filtrated precipitate is refined; 5.6 grams of pure pteroylglutamic acid is obtained.

    Therapeutic Function

    Treatment of B vitamin (folacin) deficiency

    Allgemeine Beschreibung

    Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

    Air & Water Reaktionen

    Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

    Reaktivit?t anzeigen

    Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.

    Brandgefahr

    Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

    Sicherheitsprofil

    Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

    Veterinary Drugs and Treatments

    Folic acid is used to treat folic acid deficiency in dogs, cats, and horses (theoretically in other animal species as well) often due to small intestinal disease. Cats with exocrine pancreatic insufficiency appear to be most at risk for folate and cobalamin deficiencies secondary to malabsorption of folic acid in the diet. Dogs with exocrine pancreatic insufficiency often are noted to have increased folate levels secondary to overgrowths of folate-synthesizing bacteria in the proximal small intestine. Chronic administration of dihydrofolate reductase inhibiting drugs such as pyrimethamine, ormetoprim or trimethoprim can potentially lead to reduced activated folic acid (tetrahydrofolic acid); folic acid supplementation is sometimes prescribed in an attempt to alleviate this situation.

    l?uterung methode

    If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

    Folsure Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


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    59-30-3(Folsure)Verwandte Suche:


    • EZNA KIT FUNGAL DNA MINI
    • KIT BLOOD DNA EZNA 5 TESTS
    • PTEROYL-L-GLUTAMIC ACID
    • PTEROYLMONOGLUTAMIC ACID
    • PTEROYLGLUTAMIC ACID
    • PTEROYGLUTAMIC ACID
    • PTEGLU
    • PGA
    • nzoyl]-
    • Pteroyl-L-monoglutamic acid
    • pteroyl-l-monoglutamicacid
    • USAF cb-13
    • usafcb-13
    • Vitamin Be
    • vitaminbe
    • NATURALFOLATEFROMFOOD
    • FOLICACIDSUPPLEMENTS
    • PTEROYLMONOGLUTAMATE
    • FOLSAEURE
    • Folsure
    • 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino PteGlu Pteroyl-L-glutamic acid Vitamin M PGA Pteroylglutamic acid Folic Acid Hydrate
    • Folic acids
    • Vitamin B
    • FMOC-XANTHYL-L-CYSTEINE
    • Folic acid >98%
    • Acidum folicum, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
    • PteGlu, Pteroyl-L-glutamic acid, Vitamin M
    • Vitamin M (Folic Acid)
    • N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]glutamic acid
    • N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]gluamic acid
    • Folic acid, 96-102%, pure
    • N-[4-[[(2-Amino-1,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid
    • FOLIC ACID(VITAMIN M)(P)
    • 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino PteGlu
    • Folic acid Meets USP testing specifications
    • Folic acid 0.2
    • L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
    • (2S)-2-[[4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoyl]amino]glutaric acid dihydrate
    • (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid dihydrate
    • (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]pentanedioic acid dihydrate
    • Folic acid Vetec(TM) reagent grade, >=97%
    • (2S)-2-[[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]-oxomethyl]amino]pentanedioic acid dihydrate
    • (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid dihydrate
    • N-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)glutamic acid dihydrate
    • Pteroyl
    • Folic acid Solution, 100ppm
    • Folic acid Manufacturer
    • N-[4-[[(2-AMINO-4-HYDROXY-6-PTERIDYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID
    • n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid
    • VITIMIN M
    • VITAMIN BC
    • Vitamin B11
    • VITAMIN M
    • INCAFOLIC
    • FOLSAN
    • FOLSAURE
    • FOLIC ACID
    • FOLIC ACID HYDRATE
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