• ChemicalBook
    Chinese english Germany Japanese Korea

    Hydrochlorothiazid Produkt Beschreibung

    Hydrochlorothiazide Struktur
    58-93-5
    CAS-Nr.
    58-93-5
    Bezeichnung:
    Hydrochlorothiazid
    Englisch Name:
    Hydrochlorothiazide
    Synonyma:
    HCZ;HCTZ;Ziac;Zide;Nefrix;Oretic;roxane;su5879;Bremil;Cidrex
    CBNumber:
    CB5383966
    Summenformel:
    C7H8ClN3O4S2
    Molgewicht:
    297.74
    MOL-Datei:
    58-93-5.mol

    Hydrochlorothiazid Eigenschaften

    Schmelzpunkt:
    273 °C
    Siedepunkt:
    577.0±60.0 °C(Predicted)
    Dichte
    1.6761 (rough estimate)
    Brechungsindex
    1.6100 (estimate)
    Flammpunkt:
    9℃
    storage temp. 
    2-8°C
    L?slichkeit
    Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides
    pka
    7.9, 9.2(at 25℃)
    Aggregatzustand
    solid
    Wasserl?slichkeit
    722mg/L(25 ºC)
    maximale Wellenl?nge (λmax)
    318nm(H2O)(lit.)
    Merck 
    14,4781
    BRN 
    625101
    Stabilit?t:
    Stable. Incompatible with strong oxidizing agents.
    InChIKey
    JZUFKLXOESDKRF-UHFFFAOYSA-N
    CAS Datenbank
    58-93-5(CAS DataBase Reference)
    IARC
    2B (Vol. 50, 108) 2016
    NIST chemische Informationen
    6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide(58-93-5)
    EPA chemische Informationen
    Hydrochlorothiazide (58-93-5)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xi,T,F,Xn
    R-S?tze: 22-42/43-36/38-23/25-36/37/38-39/23/24/25-23/24/25-11
    S-S?tze: 22-24-36/37-45-33-16-7-36/37/39-27-26
    RIDADR  UN 1230 3/PG 2
    WGK Germany  2
    RTECS-Nr. DK9100000
    Hazard Note  Irritant
    TSCA  Yes
    HS Code  29350090
    Giftige Stoffe Daten 58-93-5(Hazardous Substances Data)
    Toxizit?t LD50 in mice (mg/kg): 590 i.v.; >8000 orally (Piala)
    Bildanzeige (GHS)
    Alarmwort Achtung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
    H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
    H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
    H370 Sch?digt die Organe. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
    Sicherheit
    P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
    P260 Dampf/Aerosol/Nebel nicht einatmen.
    P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
    P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
    P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

    Hydrochlorothiazid Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R22:Gesundheitssch?dlich beim Verschlucken.
    R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
    R36/38:Reizt die Augen und die Haut.
    R23/25:Giftig beim Einatmen und Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

    S-S?tze Betriebsanweisung:

    S22:Staub nicht einatmen.
    S24:Berührung mit der Haut vermeiden.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
    S33:Ma?nahmen gegen elektrostatische Aufladungen treffen.
    S16:Von Zündquellen fernhalten - Nicht rauchen.
    S7:Beh?lter dicht geschlossen halten.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S27:Beschmutzte, getr?nkte Kleidung sofort ausziehen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

    Chemische Eigenschaften

    White Solid

    Originator

    Hydrodiuril,MSD,US,1959

    Verwenden

    Hydrochlorothiazide is one of the most widely used drugs of this series, and it is used for the same indications, as is chlorothiazide. Hydrochlorothiazide causes less inhibition of carbonic anhydrase, but causes 5–10 times more diuresis of sodium ions than chlorothiazide using the same dose.

    Verwenden

    A carbonic anhydrase inhibitor. Diuretic.

    Verwenden

    Labelled Hydrochlorothiazide (H714560). Hydrochlorothiazide is a carbonic anhydrase inhibitor as a diuretic.

    Definition

    ChEBI: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

    Manufacturing Process

    As described in US Patent 3,163,645, a mixture of 2.9 grams of 5-chloro-2,4- disulfamyl aniline in 15 ml of anhydrous diethyleneglycol dimethyl ether, 0.5 ml of an ethyl acetate solution containing 109.5 grams of hydrogen chloride per 1,000 ml and 0.33 grams (0.011 mol) of paraformaldehyde is heated to 80° to 90°C and maintained at that temperature for 1 hour. The resulting mixture is cooled to room temperature and concentrated to one-third of its volume under reduced pressure, diluted with water, then allowed to crystallize. The product is filtered off and recrystallized from water, to yield the desired 6-chloro-7-sulfamyl-3,4-dihydro-2H-[1,2,4]-benzothiadiazine-1,1- dioxide, MP 266° to 268°C, yield 1.4 grams. By replacing paraformaldehyde by 0.84 gram of 1,1 -dimethoxymethane and proceeding as above, the same compound is obtained.
    As described in US Patent 3,025,292, the desired product may be made by hydrogenation of chlorothiazide. Three grams of 6-chloro-7-sulfamyl-1,2,4- benzothiadiazine-1,1-dioxide (chlorothiazide) is suspended in 100 ml of methanol. Then 1.0 gram of a 5% ruthenium on charcoal catalyst is added, and the mixture is reduced at room temperature and at an initial hydrogen pressure of 39 psig. The theoretical amount of hydrogen to form the 3,4- dihydro derivative is absorbed after a period of about 10 hours.
    The reduction mixture then is heated to boiling and filtered hot to remove the catalyst. The catalyst is washed with a little methanol and the combined filtrate is concentrated to a volume of about 25 ml by evaporation on a steam bath. Upon cooling to room temperature, white crystals separate which are filtered, washed with water, and dried in vacuo at room temperature over phosphorus pentoxide overnight. The weight of 6-chloro-7-sulfamyl 3,4- dihydro-1,2,4-benzothiadiazine-1,1-dioxide obtained is 1.26 grams; MP 268.5° to 270°C. Dilution of the above filtrate with water to a volume of about 125 ml gives a second crop of product having the same melting point and weighing 1.22 grams, giving a combined yield of 83%. When the product is mixed with an authentic sample of 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide, prepared by another method, the melting point is not depressed.

    Trademarks

    Esidrix (Novartis); Hydro-D (Halsey); Hydrodiuril (Merck); Microzide (Watson); Oretic (Abbott); Zide (Solvay Pharmaceuticals).

    Therapeutic Function

    Diuretic

    Allgemeine Beschreibung

    Crystals or white powder.

    Air & Water Reaktionen

    Insoluble in water.

    Reaktivit?t anzeigen

    Strong reducing agents will produce toxic gases ammonia and hydrogen sulfide.

    Brandgefahr

    Flash point data for Hydrochlorothiazide are not available but Hydrochlorothiazide is probably combustible.

    Sicherheitsprofil

    Poison bp intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: sodum level changes, chlorine level changes, acute pulmonary edema, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A duetic. When heated to decomposition it emits very toxic fumes of SOx, Cl-, and NOx.

    Chemical Synthesis

    Hydrochlorothiazide, 1,1-dioxide 6-chloro-3,4-dihydro-2H-1,2,4- benzothiadiazin-7-sulfonamide (21.3.4), is synthesized either by cyclization of 4,6-sulfonamido- 3-chloroaniline (21.3.2) using paraformaldehyde, during which simultaneous reduction of the double bond occurs at position C3–C4, or the drug is synthesized by reduction of the same double bond in chlorothiazide (21.3.3) by formaldehyde. This small change in structure increases activity of the drug in comparison with chlorothiazide, and increases its absorbability when used orally.

    Veterinary Drugs and Treatments

    In veterinary medicine, furosemide has largely supplanted the use of thiazides as a general diuretic (edema treatment). Thiazides are still used for the treatment of systemic hypertension, nephrogenic diabetes insipidus, and to help prevent the recurrence of calcium oxalate uroliths in dogs.

    Hydrochlorothiazid Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Hydrochlorothiazid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 345)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
    Guangzhou PI PI Biotech Inc
    +8618371201331
    020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
    Baoji Guokang Bio-Technology Co., Ltd.
    09173909592
    09173909592 cngksw@aliyun.com CHINA 9447 58
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com CHINA 22607 55
    Shanxi Naipu Import and Export Co.,Ltd
    +8613734021967
    kaia@neputrading.com CHINA 1011 58
    Shanghai Zheyan Biotech Co., Ltd.
    18017610038
    zheyansh@163.com CHINA 3623 58
    career henan chemical co
    +86-371-86658258
    sales@coreychem.com CHINA 29961 58
    Hubei Jusheng Technology Co.,Ltd.
    86-18871470254
    027-59599243 linda@hubeijusheng.com CHINA 28229 58
    Hebei Guanlang Biotechnology Co., Ltd.
    +8619930503282
    sales3@crovellbio.com China 5361 58
    hdzhl biotechnology co., ltd
    86-13032617415
    sales@luchibiology.com CHINA 1275 58
    Xiamen AmoyChem Co., Ltd
    +86 592-605 1114
    sales@amoychem.com CHINA 6369 58

    58-93-5(Hydrochlorothiazid)Verwandte Suche:


    • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
    • 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-,1,1-dioxide
    • 3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
    • 6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide
    • 6-Chloro-3,4-dihydro-7-sulphamoyl-1,2,4-ben-zoth-iadi-azine1,1-dioxcide
    • 6-chloro-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine
    • 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
    • 200-403-3
    • 6-chloro-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine-1,1-dioxide
    • 6-chloro-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine1,1-dioxide
    • Acuretic
    • Aldactazide
    • aldactazide25/25
    • aldectazide50/50
    • Aldoril
    • aldorild30
    • mictrin
    • Moduretic
    • nc1-c55925
    • NCI-C55925
    • Nefrix
    • Neo-codema
    • Neoflumen
    • Newtolide
    • Oretic
    • Palonyl
    • Panurin
    • Perovex
    • Primogyn
    • Prinzide
    • Ro-hydrazide
    • roxane
    • Ser-Ap-Es
    • Servithiazid
    • spironazide
    • Su 5879
    • su5879
    • Thiaretic
    • Thiazide, hydrochloro-
    • Thiuretic
    • Thlaretic
    • Timolide
    • Unipres
    • 6-CHLORO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
    • 6-CHLORO-1,1-DIOXO-1,2,3,4-TETRAHYDRO-1LAMBDA6,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE
    • 6-CHLORO-7-SULFAMYL-3,4-DIHYDRO-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
    • Hydrochlorothiazide Impurity
    • Hydrochlorothiazide IMP
    • 6-Chloro-7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
    • HYDROCHLOROTHIAZIDE USP
    • HYDROCHLOROTHIAZIDE CARBONIC ANHYDRASE I N
    • HYDROCHLOROTHIAZIDE METHANOL SOLUTION
    • Hydrochlorothiazide,98+%
    • Hydrochlorothiazide BP2000 Ep,USP25
    • HYDROCHLOROTHIAZIDE,1.0MG/MLINMETHANOL
    • 4-chloro-10,10-dioxo-10-lamda 6-thia-7,9-diazabicyclo[4.4.0]deca-1,3,5-triene
    • Hidroclorotiazida
    • 7-Sulphamoyl-6-chlor,3,4-dihydro-2H-1,2,4-benzothiadiazine-1, 1-dioxide
    Copyright 2019 ? ChemicalBook. All rights reserved