• ChemicalBook
    Chinese english Germany Japanese Korea

    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Produkt Beschreibung

    Genistein Struktur
    446-72-0
    CAS-Nr.
    446-72-0
    Bezeichnung:
    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron
    Englisch Name:
    Genistein
    Synonyma:
    GEN;G2535;BIO-00;prunetol;GLYCITEN;GeniVida;NPI 031L;enistein;GENISTEIN;Bonistein
    CBNumber:
    CB6163787
    Summenformel:
    C15H10O5
    Molgewicht:
    270.24
    MOL-Datei:
    446-72-0.mol

    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Eigenschaften

    Schmelzpunkt:
    297-298 °C
    Siedepunkt:
    333.35°C (rough estimate)
    Dichte
    1.2319 (rough estimate)
    Brechungsindex
    1.6000 (estimate)
    storage temp. 
    -20°C
    L?slichkeit
    DMSO: soluble
    pka
    6.51±0.20(Predicted)
    Aggregatzustand
    powder
    Farbe
    off-white
    Wasserl?slichkeit
    insoluble
    Merck 
    14,4391
    BRN 
    263823
    Stabilit?t:
    Light Sensitive
    InChIKey
    TZBJGXHYKVUXJN-UHFFFAOYSA-N
    CAS Datenbank
    446-72-0(CAS DataBase Reference)
    EPA chemische Informationen
    4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xi,Xn
    R-S?tze: 36/38-22
    S-S?tze: 26-24/25-22
    WGK Germany  3
    RTECS-Nr. NR2392000
    TSCA  Yes
    HazardClass  IRRITANT
    HS Code  29329990
    Giftige Stoffe Daten 446-72-0(Hazardous Substances Data)
    Bildanzeige (GHS)
    Alarmwort Warnung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
    Sicherheit

    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R36/38:Reizt die Augen und die Haut.

    S-S?tze Betriebsanweisung:

    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S24/25:Berührung mit den Augen und der Haut vermeiden.
    S22:Staub nicht einatmen.

    Chemische Eigenschaften

    Yellow Crystalline Solid

    Verwenden

    genistein is an isoflavone commonly found in soy. It has demonstrated uV-protection properties through anti-oxidant activity. Studies indicate genistein can promote collagen synthesis, making it applicable in anti-aging cosmetics.

    Verwenden

    Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

    Verwenden

    Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

    Verwenden

    cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase

    Definition

    ChEBI: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.

    Allgemeine Beschreibung

    Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

    Biologische Aktivit?t

    Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .

    Biochem/physiol Actions

    Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

    Anticancer Research

    It is an isoflavone and is obtained from a variety of plants like psoralea (Psoraleacorylifolia), kudzu (Pueraria lobata), faba beans (Vicia faba), and soybeans(Glycine max). It exhibits anticancer effect by inhibiting NF-κB and protein kinaseB (Akt) signaling pathways (Singh et al. 2016b). It blocks the proliferation of cancercells via the inhibition of cell growth enzymes and survival like tyrosine kinase andtopoisomerase II; hence it is used to treat leukemia. Genistein increases the growthrate of some estrogen receptors in breast cancer cells and the rate of proliferation of estrogen-dependent breast cancer by competitive binding to the estrogen-β receptors.It may be involved in JNK pathway in inducing activator protein-1(AP-1) activity(Wang et al. 2012; Dixon and Ferreira 2002).

    Sicherheitsprofil

    Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

    l?uterung methode

    Crystallise it from EtOH or aqueous EtOH. It has UV: max at 290nm (EtOH). The S(-)-enantiomer (natural form) has m 255-256o (from EtOH) and [] D 20 -28.0o (c 2, EtOH), [ ] D 20 -35.2o (c 1, pyridine).[Beilstein 18 H 503, 18 II 164, 18 III/IV 2630.] Genistein (4',5,7-trihydroxyisoflavone) [446-72-0]M 270.2 crystallises from 60% aqueous EtOH or water with m 297-298o and [] D 20 -28o (c 0.6, 20mM NaOH). [Beilstein 18/4 V 594.]For Naringin (naringenin 7-rhamnoglucoside) See “Carbohydrates” in Chapter 6.

    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 606)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
    Aktin Chemicals, Inc.
    028-85159085
    86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
    Capot Chemical Co.,Ltd.
    +86(0)13336195806 +86-571-85586718
    +86-571-85864795 sales@capotchem.com China 20012 60
    Henan DaKen Chemical CO.,LTD.
    +86-371-66670886
    info@dakenchem.com China 15426 58
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com China 22607 55
    Hangzhou FandaChem Co.,Ltd.
    008615858145714
    +86-571-56059825 fandachem@gmail.com CHINA 9143 55
    Nanjing ChemLin Chemical Industry Co., Ltd.
    025-83697070
    product@chemlin.com.cn CHINA 3013 60
    Nanjing Finetech Chemical Co., Ltd.
    025-85710122 17714198479
    025-85710122 sales@fine-chemtech.com CHINA 890 55
    Shanxi Naipu Import and Export Co.,Ltd
    +8613734021967
    kaia@neputrading.com CHINA 1011 58
    Shanghai Zheyan Biotech Co., Ltd.
    18017610038
    zheyansh@163.com CHINA 3623 58
    career henan chemical co
    +86-0371-55982848
    sales@coreychem.com China 29953 58

    446-72-0(5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron)Verwandte Suche:


    • 4’,5,7-trihydroxy-isoflavon
    • prunetol
    • sophoricol
    • 4',5,7-TRIHYDROXYISOFLAVONE
    • 5,7,4'-TRIHYDROXYISOFLAVONE
    • 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
    • 5,7-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
    • AKOS NCG1-0029
    • GENISTEIN
    • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
    • GENISTEIN RESEARCH GRADE
    • Genistein,4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • GLYCITEN
    • Bonistein
    • Bonistein TG
    • Genistein (15 mg)
    • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
    • Golden sparrow isoflavone
    • GeniVida
    • NPI 031L
    • Genistein, synthetic, 99% 25MG
    • Genistein SynonyMs 4',5,7-Trihydroxyisoflavone
    • Genistein 0.25
    • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
    • c.i.75610
    • differenola
    • genistein(synthetic)
    • genisteol
    • genisterin
    • Natural Genistein
    • GENISTEIN FROM GLYCINE MAX (SOYBEAN)
    • GENISTEIN FROM SOYBEAN 98%(HPLC)
    • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
    • 4',5,7-trihydroisoflavon
    • Genistein98%,99%
    • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-(4H)-benzopyran-4-one
    • 4,5,7-TRIHYDROXYISO-FLAVONE(GENISTEIN)
    • GENESTEIN
    • GENISTEIN 98.0% (EXTRACTION)
    • GENISTEIN 98.5% (SYNTHETIC)
    • DIENISTEIN
    • Genistein 99.0%min
    • Genistein >98%
    • Genistein, 98% (4’,5,7-Trihydroxyisoflavone)
    • Genisteol&Prunetol
    • Genistein (C.I. 75610)
    • 4',5,7-Trihydroxyisoflavone
    • 4H-1-Benzopyran-4-one,5,7-dihydroxy-3-
    • Baichanin A
    • Genistein ,99%
    • GENISTEIN, 99%, SYNTHETIC
    • 4μ,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • Genista tinctoria Linn
    • 5,7-Trihydroxyisof
    • Bio1_000445
    • BRN 0263823
    • BSPBio_002375
    • CCRIS 7675
    Copyright 2019 ? ChemicalBook. All rights reserved