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    Aniracetam Produkt Beschreibung

    Aniracetam Struktur
    72432-10-1
    CAS-Nr.
    72432-10-1
    Englisch Name:
    Aniracetam
    Synonyma:
    sarpul;AMpaMet;anixiku;draganon;Ro 13-3057;RO 13-5057;ANIRACETAM;Tegumetine;Anitracetam;Ro-13-5057/001
    CBNumber:
    CB6185499
    Summenformel:
    C12H13NO3
    Molgewicht:
    219.24
    MOL-Datei:
    72432-10-1.mol

    Aniracetam Eigenschaften

    Schmelzpunkt:
    121-122?C
    Siedepunkt:
    399.7±34.0 °C(Predicted)
    Dichte
    1.236±0.06 g/cm3(Predicted)
    storage temp. 
    Sealed in dry,Room Temperature
    pka
    -1.74±0.20(Predicted)
    Wasserl?slichkeit
    Soluble in chloroform. Also soluble in ethanol. Insoluble in water
    Merck 
    14,662
    InChIKey
    ZXNRTKGTQJPIJK-UHFFFAOYSA-N
    CAS Datenbank
    72432-10-1(CAS DataBase Reference)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    WGK Germany  2
    RTECS-Nr. UY5781900
    Toxizit?t LD50 in rats, mice (mg/kg): ~4500, >5000 orally (Cumin)
    Bildanzeige (GHS)
    Alarmwort
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
    Sicherheit

    Aniracetam Chemische Eigenschaften,Einsatz,Produktion Methoden

    Beschreibung

    Aniracetam is a non-NMDA receptor agent useful for the treatment of cognitive impairment. In a clinical study, it showed good to very good improvement in 60% of patients with cerebral insufficiency. Statistically significant improvement in the psychobehavioral parameters has been observed in a group of patients with senile dementia of the Alzheimer’s type. Aniracetam is well tolerated and efficacious in improving velocity and accuracy of the saccades, complex reaction time, and other aspects of performance compared with placebo group in hypoxic volunteers. Its nootropic property has been attributed to the cholinergic blockade.

    Chemische Eigenschaften

    Crystalline Solid

    Originator

    Roche (Switzerland)

    Verwenden

    cognitive enhancer

    Verwenden

    Cognition enhancer related to Piracetam. Nootropic.

    Manufacturing Process

    40.0 g of p-methoxybenzoyl chloride, 25.0 g of 2-pyrrolidinone and 110 ml of absolute diethyl ether are treated at between 0°C and 10°C while stirring with 52.5 ml of triethylamine. The mixture is stirred at room temperature for a further 30 minutes and at reflux for 3 hours, then cooled down and treated at 2°C with cold water. The insoluble constituents are filtered off under suction and washed with water and diethyl ether. The thus obtained solid substance is recrystallized from alcohol after drying over phosphorus pentoxide. There is obtained 1-(p-methoxybenzoyl)-2-pyrrolidinone which melts at 121°-122°C.

    Trademarks

    Draganon; Sarpul;Ampamet; Reset

    Therapeutic Function

    Nootropic

    Biologische Aktivit?t

    Nootropic, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration.

    l?uterung methode

    Purify aniracetam by recrystallisation from EtOH. It is a nootropic (Alzheimer) drug. [Gouliaev & Senning Brain Research Rev 19 180 1994.]

    Aniracetam Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Aniracetam Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 318)Lieferanten
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    72432-10-1()Verwandte Suche:


    • 1-(4-methoxybenzoyl)-2-pyrrolidinon
    • 1-(p-methoxybenzoyl)-2-pyrrolidinon
    • 1-p-anisoyl-2-pyrrolidinone
    • AMpaMet
    • Ro 13-3057
    • Aniracetam, >=99%
    • Aniracetam Aniracetam
    • anixiku
    • AniracetaAniracetamm
    • draganon
    • sarpul
    • 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE
    • RO 13-5057
    • 2-PYRROLIDINONE,1-(4-METHOXYBENZOYL)
    • 1-(4-Methoxybenzoyl)-2-pyrrolidinone, Ro 13-5057
    • 1-(4-methoxybenzoyl)-2-pyrrolidone
    • 1-(4-methoxyphenyl)carbonylpyrrolidin-2-one
    • ANIRACETAM
    • 1-(4-Methoxybenzoyl)pyrrolidin-2-one
    • Ro-13-5057/001
    • Anitracetam
    • Tegumetine
    • Aniracetam/Sarpul
    • Aniracetam/C12H13NO3
    • Aniracetam >
    • Aniracetam USP/EP/BP
    • 72432-10-1
    • Aromatics
    • Heterocycles
    • Intermediates & Fine Chemicals
    • Pharmaceuticals
    • Glutamate
    • pharmaceutical intermediate
    • Smart drug
    • Nootropic
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