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    3,4-Dihydroxyzimtsure Produkt Beschreibung

    Caffeic acid Struktur
    331-39-5
    CAS-Nr.
    331-39-5
    Bezeichnung:
    3,4-Dihydroxyzimtsure
    Englisch Name:
    Caffeic acid
    Synonyma:
    Caffeic;31-39-5;NSC 623438;CAFFIC ACID;CAFFEIC ACID;AKOS B004050;Caffeic acid 0;cis-caffeicaci;Caffeicacid,96%;CaffeicAcidPure
    CBNumber:
    CB6281061
    Summenformel:
    C9H8O4
    Molgewicht:
    180.16
    MOL-Datei:
    331-39-5.mol

    3,4-Dihydroxyzimtsure Eigenschaften

    Schmelzpunkt:
    211-213 °C (dec.) (lit.)
    Siedepunkt:
    272.96°C (rough estimate)
    Dichte
    1.2933 (rough estimate)
    Brechungsindex
    1.4500 (estimate)
    storage temp. 
    2-8°C
    L?slichkeit
    ethanol: 50 mg/mL
    pka
    4.58±0.10(Predicted)
    Aggregatzustand
    powder
    Farbe
    yellow to tan
    Wasserl?slichkeit
    soluble in hot water
    Merck 
    14,1635
    BRN 
    2210883
    Stabilit?t:
    Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
    InChIKey
    QAIPRVGONGVQAS-DUXPYHPUSA-N
    CAS Datenbank
    331-39-5(CAS DataBase Reference)
    IARC
    2B (Vol. 56) 1993
    NIST chemische Informationen
    Cinnamic acid, 3,4-dihydroxy-(331-39-5)
    EPA chemische Informationen
    2-Propenoic acid, 3-(3,4-dihydroxyphenyl)- (331-39-5)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xn,Xi
    R-S?tze: 36/37/38-40-63-68
    S-S?tze: 26-36/37/39-36
    WGK Germany  3
    RTECS-Nr. GD8950000
    Hazard Note  Irritant
    HS Code  29182990
    Giftige Stoffe Daten 331-39-5(Hazardous Substances Data)
    Bildanzeige (GHS)
    Alarmwort Warnung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
    H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
    H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
    H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
    H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
    Sicherheit
    P201 Vor Gebrauch besondere Anweisungen einholen.
    P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
    P261 Einatmen von Staub vermeiden.
    P264 Nach Gebrauch gründlich waschen.
    P264 Nach Gebrauch gründlich waschen.
    P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
    P405 Unter Verschluss aufbewahren.
    P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

    3,4-Dihydroxyzimtsure Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R40:Verdacht auf krebserzeugende Wirkung.
    R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.
    R68:Irreversibler Schaden m?glich.

    S-S?tze Betriebsanweisung:

    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

    Beschreibung

    Caffeic acid is abundant in the whole plant of Solidago decurrens Lour. (Yi Zhi Huang Hua), fruit of Crataegus pinnatifida Bge. var. major N.E.Br. (Shan Li Hong), Salix myrtillacea Anderss. (Po Liu), rhizome of Cimicifuga foetida L., rhizome of Polypodiaceae Polypodium vulgare L. (Ou Ya Shui Long Gu), peel of Rutaceae Citrus limonum (Ning Meng), the whole plant of Polygonaceae Polygonum aviculare L. (Pian Xu), root of Valeriana officinalis L. (Xie Cao), the whole plant of Thymus mongolicus Ronn (She Xiang), leaves of Eucommia ulmoides (Du Zhong), and other herbal plants. It is a kind of polyhydroxy styrene acid, with the general chemical properties of phenolic acid. It is easily oxidized for the reason of the unsaturated double bonds, particularly unstable in alkaline solution
    Caffeic acid has both cis and trans isomers, and the two isomers of caffeic acid have a mutual transformation in plants, which may regulate some important physiological process. Caffeic acid exists in plants in the main form of complexes; free state accounts for a few proportion.

    Beschreibung

    Caffeic acid is an inhibitor of 5-LO with an IC50 value of 3.7-72 μM and 12-LO with an IC50 value of 5.1-30 μM.

    Chemische Eigenschaften

    Light yellow to greenish-yellow powder

    Physikalische Eigenschaften

    Appearance: yellow crystal. The crystal from the concentrated solution does not contain crystal water, and the crystal from the dilute solution contains one molecule crystal water. Melting point: 223?225?°C. Solubility: It is slightly soluble in cold
    water but soluble in hot water, cold ethanol, and ethyl acetate. The basic solution is orange-red. Ferric chloride solution was dark green.

    Verwenden

    Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis. It has also been used to determine its antioxidant activity by various assay methods.

    Verwenden

    antineoplastic, PGE2 synthase inhibitor, PK inhibitor

    Verwenden

    Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi.

    Indications

    It is used for preventing or stopping bleeding during surgery, as well as hemostasis in the department of medicine, obstetrics and gynecology, etc. It is also used for various causes of neutropenia and thrombocytopenia.

    Allgemeine Beschreibung

    Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.

    Air & Water Reaktionen

    Insoluble in water.

    Reaktivit?t anzeigen

    Caffeic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Caffeic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

    Health Hazard

    ACUTE/CHRONIC HAZARDS: When heated to decomposition Caffeic acid emits acrid smoke and fumes.

    Brandgefahr

    Flash point data for Caffeic acid are not available; however, Caffeic acid is probably combustible.

    Biochem/physiol Actions

    A natural dietary phenolic compound found in plants that is an anti-oxidant. Inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy. Inhibits Cu2+-induced LDL oxidation.

    l?uterung methode

    Recrystallise this antioxidant from water. [Beilstein 10 IV 1776.]

    3,4-Dihydroxyzimtsure Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    3,4-Dihydroxyzimtsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 555)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
    Hangzhou Viablife Biotech Co., Ltd.
    +1 435-5570519 01-435-5570519
    86-571-88766836 info@viablife.com CHINA 12 58
    Shaanxi Yikanglong Biotechnology Co., Ltd.
    17791478691
    yklbiotech@163.com CHINA 297 58
    Aktin Chemicals, Inc.
    028-85159085
    86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
    Shanghai Rochi Pharmaceutical Co.,Ltd.
    15000076078 0086-21-38751876
    info@rochipharma.com CHINA 432 58
    Henan DaKen Chemical CO.,LTD.
    +86-371-66670886
    info@dakenchem.com China 15426 58
    Dongfan Chem. Co., Ltd.
    021-34500607 13391355195
    021-33321290 sales@dfanchem.com CHINA 61 55
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com China 22607 55
    Hangzhou FandaChem Co.,Ltd.
    008615858145714
    +86-571-56059825 fandachem@gmail.com CHINA 9143 55
    Nanjing Finetech Chemical Co., Ltd.
    025-85710122 17714198479
    025-85710122 sales@fine-chemtech.com CHINA 890 55
    Hefei TNJ Chemical Industry Co.,Ltd.
    +86-0551-65418679
    86-0551-65418697 info@tnjchem.com China 3000 55

    331-39-5(3,4-Dihydroxyzimtsure)Verwandte Suche:


    • RARECHEM BK HC T335
    • TIMTEC-BB SBB006475
    • 4-(2’-carboxyvinyl)-1,2-dihydroxybenzene
    • 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
    • 4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene
    • CAFFEIC ACID
    • 3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID
    • 3-(3,4-DIHYDROXYPHENYL)ACRYLIC ACID
    • Caffeicacid,96%
    • CAFFEIC ACID, MATRIX SUBSTANCE FOR MALDI -MS
    • 3,4-DIHYDROXYCINNAMIC ACID, 97%, PREDOMINANTLY TRANS
    • 3,4-DIHYDROXYCINNAMIC ACID (CAFFEIC ACID)
    • CaffeicAcidPure
    • CAFFIC ACID
    • 3,4-Dihydroxycinnamic acid, predominantly trans isomer, 99+%
    • LABOTEST-BB LT00233168
    • 3,4-DIHYDROXYCINNAMIC ACID
    • AKOS B004050
    • NSC 623438
    • (Z)-3-(3,4-dihydroxyphenyl)acrylic acid
    • Caffeic
    • CAFFEICACID(BULK
    • Caffeic acid 0
    • (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
    • Caffeic acid, 99%, predoMinantly trans
    • Caffeic acid, predoMinantly trans
    • (2E)-3-(3,4-Dihydroxyphenyl)-2-propenoic acid
    • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-
    • 3-(3,4-dihydroxyphenyl)-2-propenoicaci
    • 3-(3,4-Dihydroxyphenyl)propenoic acid
    • 3,4-Dihydroxybenzeneacrylic acid
    • 3,4-dihydroxybenzeneacrylicacid
    • 3,4-dihydroxy-cinnamicaci
    • 3,4-dihydroxycinnamicacid,predominantlytransisomer
    • CAFFEIC ACID(AHP)
    • 3,4-Dihydroxycinnamic acid, 99+%, predominantly trans isomer
    • CINNAMICACID,3,4-DIHYDROXY-
    • CAFFEIC ACID NATURAL
    • CAFFEIC ACID SYNTHETIC
    • (E)-3-(3,4-Dihydroxyphenyl)acrylic acid
    • (E)-3,4-Dihydroxycinnamic acid
    • 3,4-Dihydroxy-trans-cinnamic acid
    • trans-Caffeic acid
    • 3,4-Dihydroxycinnamic acid, 99%, predominantly trans
    • 3,4-Dihydroxycynnamic acid
    • 3,4-Dihydroxycinnamic acid, predominantly trans, 99%
    • 3,4-dihydroxyben
    • Caffeic acid ,99%
    • 3,4-dihydroxy-acid
    • Caffeic acid, 3-(3,4-Dihydroxyphenyl)prop-2-enoic acid, 3-(3,4-Dihydroxyphenyl)acrylic acid
    • 3,4-DihydroxycinnaMic acid, predoMinantly trans isoMer, 99+% 25GR
    • 3,4-DihydroxycinnaMic acid, predoMinantly trans isoMer, 99+% 5GR
    • Caffeic Acid 〔3,4-Dihydroxycinnamic Acid〕
    • Caffeic acid purum, >=95.0% (HPLC)
    • 3,4-Dihydroxycinnamic acid for synthesis
    • Caffeic Acid - CAS 331-39-5 - Calbiochem
    • Caffeic acid 331-39-5
    • (E)-3-(3,4-dihydroxyphenyl)-2-propenoate
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