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    3β-Hydroxyurs-12-en-28-sure Produkt Beschreibung

    Ursolic acid Struktur
    77-52-1
    CAS-Nr.
    77-52-1
    Bezeichnung:
    3β-Hydroxyurs-12-en-28-sure
    Englisch Name:
    Ursolic acid
    Synonyma:
    MALOL;URSON;UrsoL;PRUNOL;Ursolic;NSC-4060;Masterin;Merotaine;Neoage UR;MICROMEROL
    CBNumber:
    CB7470516
    Summenformel:
    C30H48O3
    Molgewicht:
    456.71
    MOL-Datei:
    77-52-1.mol

    3β-Hydroxyurs-12-en-28-sure Eigenschaften

    Schmelzpunkt:
    292 °C (dec.) (lit.)
    alpha 
    59 º (c=0.3, pyridine)
    Siedepunkt:
    502.79°C (rough estimate)
    Dichte
    1.0261 (rough estimate)
    Brechungsindex
    1.4940 (estimate)
    storage temp. 
    2-8°C
    pka
    4.68±0.70(Predicted)
    Aggregatzustand
    Crystalline Powder or Needles
    Farbe
    White to off-white
    Wasserl?slichkeit
    insoluble
    Merck 
    14,9890
    BRN 
    2228563
    CAS Datenbank
    77-52-1(CAS DataBase Reference)
    EPA chemische Informationen
    Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)- (77-52-1)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xi
    R-S?tze: 36/37/38
    S-S?tze: 24/25-36-26
    WGK Germany  -
    RTECS-Nr. YU9520000
    10-23
    HS Code  29181990
    Giftige Stoffe Daten 77-52-1(Hazardous Substances Data)
    Bildanzeige (GHS)
    Alarmwort
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
    Sicherheit

    3β-Hydroxyurs-12-en-28-sure Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

    S-S?tze Betriebsanweisung:

    S24/25:Berührung mit den Augen und der Haut vermeiden.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

    Chemische Eigenschaften

    white to light yellow crystal powde

    Verwenden

    A Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.

    Verwenden

    ursolic acid helps maintain the look and feel of the skin, acts as a perfume and helps mask odor. Therapeutic benefits in skin care include anti-inflammatory activity. ursolic acid has demonstrated anti-microbial, anti-bacterial, and anti-fungal action as well.

    Verwenden

    Ursolic Acid is a Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.Ursolic acid protects against muscle atrophy and boosts muscle growth (see also tomatidine T538500).

    Definition

    ChEBI: A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.

    Allgemeine Beschreibung

    Ursolic acid (UA) is a hydroxyl pentacyclic triterpenoic acid (HPTA), which exhibits anti-bacterial, anti-cancer, anti-oxidative and anti-inflammatory effects. It can also promote neuroregeneration after peripheral nerve injury. UA can enhance sleep duration by activating the GABAergic neurotransmitter system. [GABA= γ-aminobutyric acid]

    Biochem/physiol Actions

    Triterpenoid found in a variety of fruits, including apples. Cardioprotective and anti-tumor agent. Under study as a potential Alzheimer′s disease therapeutic due to its inhibitory effect on the interactions between amyloid-β and the CD36 receptor.

    Anticancer Research

    It is a triterpenoid, derived from basil, and suppresses the activation of NF-κB byinhibiting a kinase that activates NF-κB(IKK) (Aggarwal and Shishodia 2004). It suppresses tumorigenesis, tumor promotion, and angiogenesis by downregulationof the expression of lipoxygenases (LOX), MMP-9, and COX-2. It is reported toinduce apoptosis in breast cancer, melanoma, hepatoma, prostate cancer, andacute myelogenous leukemia by preventing replication of DNA, inhibition of proteintyrosine kinases, activation of caspases, induction of calcium release, anddownregulating apoptosis gene cellular inhibitor. Ursolic acid inhibits IκBαkinase activity, degradation of IκBα, phosphorylation, NF-κB-dependent reportergene expression, p65 nuclear translocation, and p65 phosphorylation. Inhibitionof NF-κB leads to the reduction of cyclin D1, COX-2, and MMP9 expression.This downregulates STAT-3 activation and its regulated gene products such ascyclin D1, Mcl-1, Bcl-xL, survivin, Bcl-2, and VEGF. It also induces the expressionof tyrosine phosphatase SHP-1 protein and of mRNA (Aggarwal et al. 2008;Hsu et al. 2004).

    Cytotoxicity

    IC50 (μg/mL): 6.7 (518A2), 5.3 (A2780), 7(A549), 6.4 (FaDu), 4.8 (HT29), 5.8(MCF-7), 8.5 (NIH3T3) (Wiemann et al.2016)
    IC50 (μg/mL): 12.38 (MGC-803),17.12(HCT-116), 13.39 (T24), 13.81(HepG2), 16.36 (A549), >45.7 (HL-7702)(Hua et al. 2015).

    3β-Hydroxyurs-12-en-28-sure Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    3β-Hydroxyurs-12-en-28-sure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 520)Lieferanten
    Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
    Shaanxi Pioneer Biotech Co., Ltd .
    86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
    029-84385017 sales@pioneerbiotech.com CHINA 3001 58
    Hebei Guanlang Biotechnology Co., Ltd.
    +8619930503282
    alice@crovellbio.com China 5942 58
    Aktin Chemicals, Inc.
    028-85159085
    86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
    Pharmyao, All for life--- A Specific Trading Platform For Reference Standard Material
    13560473592 020-81716320
    020-81716319 sales@pharmyao.com CHINA 173 58
    Hengshui Haoye Chemical Co.,Ltd.
    0318-2102300
    hy@chemcoms.com CHINA 224 58
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com China 22607 55
    Hangzhou FandaChem Co.,Ltd.
    008615858145714
    +86-571-56059825 fandachem@gmail.com CHINA 9150 55
    Nanjing Finetech Chemical Co., Ltd.
    025-85710122 17714198479
    025-85710122 sales@fine-chemtech.com CHINA 890 55
    Hefei TNJ Chemical Industry Co.,Ltd.
    +86-0551-65418679
    86-0551-65418697 info@tnjchem.com China 3000 55
    Shanxi Naipu Import and Export Co.,Ltd
    +8613734021967
    kaia@neputrading.com CHINA 1011 58

    77-52-1(3β-Hydroxyurs-12-en-28-sure)Verwandte Suche:


    • 3BETA-HYDROXY-12-URSEN-28-IC ACID
    • 3BETA-HYDROXY-12-URSEN-28-OIC ACID
    • 3B-HYDROXYURS-12-EN-28-OIC ACID
    • Ursolic acid 3beta-Hydroxyurs-12-en-28-oic acid
    • (1S,2R,4aS,6aS,6bR,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
    • Ursoliic acid
    • (3beta)-urs-12-en-28-oicaci
    • 3-hydroxy-,(3.beta.)-Urs-12-en-28-oicacid
    • Ursolic acid powder
    • URSOLIC ACID hplc
    • Urs-12-en-28-oic acid, 3-hydroxy-, (3)-
    • URSOLIC ACID (SAGE EXTRACT)
    • URSOLIC ACID (LIGUSTRUM LUCIDUM AIT)
    • Ursolic
    • Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-
    • (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
    • URSOLIC ACID(P)
    • URSOLIC ACID(RG)
    • URSOLIC ACID MINIMUM 90%
    • URSOLIC ACID, 90+%
    • URSONIC ACID, 98+% NATURAL STANDARD
    • URSOLIC ACID, 4%
    • URSOLIC ACID, 99+% HPLC
    • UROPORPHYRIN I ETHYL ESTER FROM BOVINE PROPHYRIC URINE
    • URSOLIC ACID, 98+%
    • LoquatLeafExtract-UrsolicAcid25-98%
    • MALOL
    • 3β-Hydroxy-12-ursen-28-ic acid
    • PRUNOL
    • SAGE EXTRACT
    • MICROMEROL
    • URSOLIC ACID
    • URSON
    • 3beta-hydroxyurs-12-en-28-oic acid
    • (1S,2R,4AS,6AS,6BR,8AR,10S,12AR,12BR,14BS)-10-HYDROXY-1,2,6A,6B,9,9,12A-HEPTAMETHYL-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-4A-CARBOXYLIC ACID
    • (3beta)-3-Hydroxy-urs-12-en-28-oic acid
    • URSOLIC ACID,95%
    • 3β-Hydroxyurs-12-en-28-oic acid
    • NSC-4060
    • beta-Ursolic Acid
    • Ursolic acid,3β-Hydroxy-12-ursen-28-ic acid
    • Bungeolic Acid
    • Ursolic acid (Malol)
    • ForMosolic acid
    • Forucosolic acid
    • Masterin
    • Merotaine
    • Neoage UR
    • NSC 167406
    • UrsolisoMe
    • 3-Hydroxy-12-ursen-28-oicacid
    • URSOLIC ACID WITH HPLC
    • Ursolic Acid SynonyMs: 3beta-Hydroxyurs-12-en-28-oic acid
    • UrsoL
    • URSOLIC ACID (PRUNOL)
    • Uosolic Acid
    • Ursolic Acid 77-52-1
    • factory price Ursolic acid 77-52-1
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