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    Benzylbenzoat Produkt Beschreibung

    Benzyl benzoate Struktur
    120-51-4
    CAS-Nr.
    120-51-4
    Bezeichnung:
    Benzylbenzoat
    Englisch Name:
    Benzyl benzoate
    Synonyma:
    BJSBZ;Zylate;ASCABIN;Scabide;Benylate;ASCABIOL;Colebenz;Scabagen;Scabanca;Scabitox
    CBNumber:
    CB9152283
    Summenformel:
    C14H12O2
    Molgewicht:
    212.24
    MOL-Datei:
    120-51-4.mol

    Benzylbenzoat Eigenschaften

    Schmelzpunkt:
    17-20 °C (lit.)
    Siedepunkt:
    323-324 °C (lit.)
    Dichte
    1.118 g/mL at 20 °C (lit.)
    Dampfdruck
    1 mm Hg ( 125 °C)
    Brechungsindex
    n20/D 1.568(lit.)
    FEMA 
    2138 | BENZYL BENZOATE
    FEMA 
    2797 | OCTANAL
    Flammpunkt:
    298 °F
    storage temp. 
    2-8°C
    L?slichkeit
    Miscible with ethanol, alcohol, chloroform, ether, oils.
    Aggregatzustand
    Liquid
    Farbe
    Clear colorless
    Wasserl?slichkeit
    practically insoluble
    JECFA Number
    24
    Merck 
    14,1127
    BRN 
    2049280
    Stabilit?t:
    Stable. Substances to be avoided include strong oxidizing agents. Combustible.
    InChIKey
    SESFRYSPDFLNCH-UHFFFAOYSA-N
    CAS Datenbank
    120-51-4(CAS DataBase Reference)
    NIST chemische Informationen
    Benzyl Benzoate(120-51-4)
    EPA chemische Informationen
    Benzyl benzoate (120-51-4)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xn,N
    R-S?tze: 22-51/53
    S-S?tze: 25-61-46
    RIDADR  UN 3082 9 / PGIII
    WGK Germany  2
    RTECS-Nr. DG4200000
    Selbstentzündungstemperatur 896 °F
    TSCA  Yes
    HazardClass  9
    HS Code  29163100
    Giftige Stoffe Daten 120-51-4(Hazardous Substances Data)
    Toxizit?t LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)
    Bildanzeige (GHS)
    Alarmwort Warnung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
    H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
    H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 2
    Sicherheit
    P264 Nach Gebrauch gründlich waschen.
    P264 Nach Gebrauch gründlich waschen.
    P270 Bei Gebrauch nicht essen, trinken oder rauchen.
    P273 Freisetzung in die Umwelt vermeiden.
    P330 Mund ausspülen.
    P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

    Benzylbenzoat Chemische Eigenschaften,Einsatz,Produktion Methoden

    ERSCHEINUNGSBILD

    FARBLOSE FLüSSIGKEIT ODER WEISSER FESTSTOFF MIT CHARAKTERISTISCHEM GERUCH.

    PHYSIKALISCHE GEFAHREN

    Die D?mpfe sind schwerer als Luft.

    CHEMISCHE GEFAHREN

    Beim Verbrennen Bildung giftiger und reizender Rauche.

    ARBEITSPLATZGRENZWERTE

    TLV nicht festgelegt (ACGIH 2005).
    MAK nicht festgelegt (DFG 2005).

    AUFNAHMEWEGE

    Aufnahme in den K?rper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.

    INHALATIONSGEFAHREN

    Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitssch?dliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.

    WIRKUNGEN BEI KURZZEITEXPOSITION

    WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz reizt die Augen, die Haut und die Atemwege.

    WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

    Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen.

    LECKAGE

    Ausgelaufene Flüssigkeit m?glichst in abdichtbaren Beh?ltern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgf?ltig sammeln. An sicheren Ort bringen. Pers?nliche Schutzausrüstung: Atemschutzger?t, P1-Filter für inerte Partikel.

    R-S?tze Betriebsanweisung:

    R22:Gesundheitssch?dlich beim Verschlucken.

    S-S?tze Betriebsanweisung:

    S25:Berührung mit den Augen vermeiden.

    Beschreibung

    Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.

    Chemische Eigenschaften

    Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor.
    Benzyl Benzoate
    Benzyl Benzoate is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.

    Occurrence

    Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).

    Verwenden

    Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies , for example as a combination drug of benzyl benzoate/disulfiram.
    It has other uses :
    a fixative in fragrances to improve the stability and other characteristics of the main ingredients
    a food additive in artificial flavors
    a plasticizer in cellulose and other polymers
    a solvent for various chemical reactions
    a treatment for sweet itch in horses
    a treatment for scaly leg mites in chickens.

    Verwenden

    As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.

    Verwenden

    benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.

    Vorbereitung Methode

    BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavors, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).

    Indications

    Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only a veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
    Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.

    synthetische

    By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.

    Trademarks

    Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop).

    Taste threshold values

    Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.

    Synthesis Reference(s)

    Journal of Heterocyclic Chemistry, 24, p. 187, 1987 DOI: 10.1002/jhet.5570240135
    Tetrahedron Letters, 27, p. 2383, 1986 DOI: 10.1016/S0040-4039(00)84535-9

    Allgemeine Beschreibung

    Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma component of cranberry, mango and Egyptian Jasminum sambac flowers.

    Hazard

    Irritant to eyes, skin.

    Pharmazeutische Anwendungen

    Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
    However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
    Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.

    Kontakt-Allergie

    Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.

    Biochem/physiol Actions

    Benzyl benzoate is the condensation product of benzoic acid and benzyl alcohol. It is utilized for treating human scabies as well as kills house dust mite.

    Clinical Use

    Benzyl benzoate is a naturally occurring ester obtained fromPeru balsam and other resins. It is also prepared syntheticallyfrom benzyl alcohol and benzoyl chloride. The ester isa clear colorless liquid with a faint aromatic odor. It is insolublein water but soluble in organic solvents.
    Benzyl benzoate is an effective scabicide when appliedtopically. Immediate relief from itching probably resultsfrom a local anesthetic effect; however, a complete cureis frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized withtriethanolamine. This preparation has the additionaladvantage of being essentially odorless, nonstaining, andnonirritating to the skin. It is applied topically as a lotionover the entire dampened body, except the face.

    Sicherheit(Safety)

    Benzyl benzoate is metabolized by rapid hydrolysis to benzoic acid and benzyl alcohol. Benzyl alcohol is then further metabolized to hippuric acid, which is excreted in the urine.
    Benzyl benzoate is widely used as a 25% v/v topical application in the treatment of scabies and as an excipient in intramuscular injections and oral products. Adverse reactions to benzyl benzoate include skin irritation and hypersensitivity reactions. Oral ingestion may cause harmful stimulation of the CNS and convulsions. Benzyl benzoate should be avoided by perople with perfume allergy.
    LD50 (cat, oral): 2.24 g/kg
    LD50 (dog, oral): 22.44 g/kg
    LD50 (guinea pig, oral): 1.0 g/kg
    LD50 (mouse, oral): 1.4 g/kg
    LD50 (rabbit, oral): 1.68 g/kg
    LD50 (rabbit, skin): 4.0 g/kg
    LD50 (rat, oral): 0.5 g/kg
    LD50 (rat, skin): 4.0 g/kg

    Chemical Synthesis

    This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.

    Environmental Fate

    Benzyl benzoate acts as a local irritant. At high levels of exposure, free benzoic acid may sequester significant amounts of acetyl coenzyme A (CoA), which could disrupt cholinergic signaling. Recent findings suggest that benzyl benzoate may have estrogenic properties.

    Stoffwechsel

    Benzyl benzoate, a relatively non-toxic liquid widely used for the treatment of scabies, is converted into benzoic acid in vivo (Williams, 1959).

    Lager

    Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided.

    Toxicity evaluation

    Acute oral LD50 for rats: 1,700 mg/kg

    Inkompatibilit?ten

    Benzyl benzoate is incompatible with alkalis and oxidizing agents.

    Regulatory Status

    Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

    Benzylbenzoat Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Benzylbenzoat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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    120-51-4(Benzylbenzoat)Verwandte Suche:


    • Benzyl benzoate ReagentPlus(R), >=99.0%
    • Benzyl benzoate Vetec(TM) reagent grade, 98%
    • Benzoic acid benzyl ester≥ 99% (GC)
    • VANZOATE(R)
    • VENZONATE(R)
    • Benylate
    • Benzyl alcohol benzoic ester
    • Benzyl ester
    • benzylalcoholbenzoicester
    • Benzylester kyseliny benzoove
    • ASCABIN
    • ASCABIOL
    • ASCABIOL(R)
    • BENZOATO DE BENCILO
    • Benzyl benzoate 99+ %
    • Phenylmethyl benzoate
    • BENZYL BENZOATE, 1GM, NEAT
    • BENZYL BENZOATE 99+% FCC
    • BENZYL BENZOATE 99+% NATURAL FCC
    • BENZYL BENZOATE, USP
    • BENZYL BENZOATE, PH EUR
    • Benzyl Benzoate PQ
    • BENZYL BENZOATE, PHARMA
    • benzylbenzoate,phenylmethylbenzoate
    • Benzylbenzoat
    • Benzyl Benoate
    • Benryl benzoate
    • spasmodin
    • Benzile benzoate
    • BENZYL BENZOATE, NATURAL
    • Benzyl benzoate, EP, BP, USP
    • benzyl benzonate
    • Benzoic acid benzyl ester, Benzylis benzoas
    • N-tert-Butoxycarbonyl-L-aspartic Acid &alpha
    • N-Boc-L-glutamic Acid &alpha
    • Benzyl benzoate, AR
    • Benzyl benzoate, >99.0%(GC)
    • Boc-DL-glutamic acid &gamma
    • Z-D-glutamic acid &gamma
    • Boc-N-methyl-L-glutamic acid &gamma
    • BJSBZ
    • Nat.Benzyl benzoate
    • benzylesterkyselinybenzoove
    • Benzylets
    • Colebenz
    • femanumber2138
    • Novoscabin
    • Peruscabin
    • Phenylmethyl (benzyl) ester
    • Scabagen
    • Scabanca
    • Scabide
    • Scabiozon
    • Scabitox
    • Scobenol
    • Vanzoate
    • Venzoate
    • Venzonate
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