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    Acetyl tributyl citrate

    Acetyl tributyl citrate
    Acetyl tributyl citrate structure
    CAS No.
    77-90-7
    Chemical Name:
    Acetyl tributyl citrate
    Synonyms
    ATBC;Blo-trol;Estaflex;FEMA 3080;Uniplex 84;citroflexa;Citroflex A;citroflexa4;Citroflex A 4;acetylbutylcitrate
    CBNumber:
    CB0408022
    Molecular Formula:
    C20H34O8
    Formula Weight:
    402.48
    MOL File:
    77-90-7.mol

    Acetyl tributyl citrate Properties

    Melting point:
    -59 °C
    Boiling point:
    327 °C
    Density 
    1.05 g/mL at 25 °C (lit.)
    vapor pressure 
    0.26 psi ( 20 °C)
    refractive index 
    n20/D 1.443(lit.)
    FEMA 
    3080 | TRIBUTYL ACETYLCITRATE
    Flash point:
    >230 °F
    storage temp. 
    Store below +30°C.
    solubility 
    Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
    form 
    neat
    Water Solubility 
    <0.1 g/100 mL
    FreezingPoint 
    -80℃
    JECFA Number
    630
    BRN 
    2303316
    InChIKey
    QZCLKYGREBVARF-UHFFFAOYSA-N
    CAS DataBase Reference
    77-90-7(CAS DataBase Reference)
    FDA 21 CFR
    172.515; 175.105; 175.300; 175.320; 181.27
    Substances Added to Food (formerly EAFUS)
    TRIBUTYL ACETYLCITRATE
    EWG's Food Scores
    1
    FDA UNII
    0ZBX0N59RZ
    NIST Chemistry Reference
    1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
    EPA Substance Registry System
    Acetyl tributyl citrate (77-90-7)
    Cosmetics Info
    Acetyl Tributyl Citrate
    SAFETY
    • Risk and Safety Statements
    Safety Statements  24/25
    WGK Germany  3
    RTECS  TZ8330000
    HS Code  29181500

    Acetyl tributyl citrate price More Price(27)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich W308005 Tributyl 2-acetylcitrate ≥98%,FG 77-90-7 1 SAMPLE $50 2021-12-16 Buy
    Sigma-Aldrich 8.14437 Tributylacetyl citrate for synthesis 77-90-7 100 mL $25.53 2021-12-16 Buy
    Sigma-Aldrich Y0001055 Tributyl acetylcitrate European Pharmacopoeia (EP) Reference Standard 77-90-7 $190 2021-12-16 Buy
    Sigma-Aldrich 1009901 Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard 77-90-7 200mg $358 2021-12-16 Buy
    Sigma-Aldrich 1009901 Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard 77-90-7 500mg $425 2021-12-16 Buy

    Acetyl tributyl citrate Chemical Properties,Uses,Production

    Chemical Properties

    clear colorless liquid

    Chemical Properties

    Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

    Chemical Properties

    Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

    Chemical Properties

    Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

    Uses

    These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

    Uses

    Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

    Uses

    plasticizer flavoring agent

    Definition

    Aqueous-based pharmaceutical coat- ings.

    Preparation

    From citric acid via the tributyl ester followed by acetylation.

    Production Methods

    Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

    General Description

    Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
    Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

    Pharmaceutical Applications

    Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

    Safety Profile

    When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

    Safety

    and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
    LD50 (cat, oral): >50 mL/kg
    LD50 (mouse, IP): >4 g/kg
    LD50 (rat, oral): >31.5 g/kg

    Carcinogenicity

    The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

    storage

    Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

    Incompatibilities

    Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

    Regulatory Status

    Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

    Acetyl tributyl citrate Preparation Products And Raw materials

    Raw materials

    Preparation Products


    Acetyl tributyl citrate Suppliers

    Global( 289)Suppliers
    Supplier Tel Fax Email Country ProdList Advantage
    Hefei TNJ Chemical Industry Co.,Ltd.
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    Hangzhou FandaChem Co.,Ltd.
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    SHANDONG ZHI SHANG CHEMICAL CO.LTD
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    Shandong chuangyingchemical Co., Ltd.
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    View Lastest Price from Acetyl tributyl citrate manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2021-12-25 Acetyl tributyl citrate
    77-90-7
    US $21.00 / KG 1KG 99% 2t XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
    2021-12-01 Acetyl Tributyl Citrate
    77-90-7
    US $5.70 / Kg/Drum 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
    2021-11-08 Acetyl tributyl citrate
    77-90-7
    US $10.00 / KG 1KG 99% 20 tons Wuhan wingroup Pharmaceutical Co., Ltd

    Acetyl tributyl citrate Spectrum


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