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    Chlorogenic acid

    Pharmacological action Protecting liver, gallbladder The inhibitory effect on hyaluronidase and glucose - 6 - phosphatase The character of molecular structure Preparation method HPLC method for determination the content Toxicity Chemical property Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage and transport properties Fire extinguishing agent
    Chlorogenic acid
    Chlorogenic acid structure
    CAS No.
    327-97-9
    Chemical Name:
    Chlorogenic acid
    Synonyms
    Scorpio。;Heriguard;NSC 70861;Buthotoxin;NSC 407296;Chlorogenic;Igasuric acid;orogenic acid;Chlorogenic ac;HELIANTHIC ACID
    CBNumber:
    CB2478906
    Molecular Formula:
    C16H18O9
    Formula Weight:
    354.31
    MOL File:
    327-97-9.mol

    Chlorogenic acid Properties

    Melting point:
    210 °C (dec.) (lit.)
    alpha 
    -36 º (c=1, H2O)
    Boiling point:
    407.55°C (rough estimate)
    Density 
    1.3594 (rough estimate)
    refractive index 
    -37 ° (C=1, H2O)
    storage temp. 
    2-8°C
    solubility 
    Soluble in ethanol and acetone.
    pka
    3.91±0.50(Predicted)
    form 
    Powder, Crystals, Needles and/or Chunks
    color 
    White to almost white
    Water Solubility 
    SOLUBLE IN HOT WATER
    Merck 
    14,2142
    InChIKey
    CWVRJTMFETXNAD-JUHZACGLSA-N
    CAS DataBase Reference
    327-97-9(CAS DataBase Reference)
    EWG's Food Scores
    1
    FDA UNII
    318ADP12RI
    NCI Drug Dictionary
    chlorogenic acid
    EPA Substance Registry System
    Chlorogenic acid (327-97-9)
    SAFETY
    • Risk and Safety Statements
    Hazard Codes  Xi
    Risk Statements  68
    Safety Statements  24/25
    WGK Germany  3
    RTECS  GU8480000
    Hazard Note  Irritant
    HS Code  29182900
    Toxicity LDLo intraperitoneal in rat: 4gm/kg

    Chlorogenic acid price More Price(17)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 1115545 Chlorogenic acid United States Pharmacopeia (USP) Reference Standard 327-97-9 50mg $126 2020-08-18 Buy
    Sigma-Aldrich Y0000569 Chlorogenic acid European Pharmacopoeia (EP) Reference Standard 327-97-9 $190 2021-03-22 Buy
    Sigma-Aldrich 00500590 Chlorogenic acid primary reference standard 327-97-9 25mg $402 2021-03-22 Buy
    TCI Chemical C0181 Chlorogenic Acid Hydrate >98.0%(HPLC)(T) 327-97-9 1g $79 2021-03-22 Buy
    TCI Chemical C0181 Chlorogenic Acid Hydrate >98.0%(HPLC)(T) 327-97-9 5g $276 2021-03-22 Buy

    Chlorogenic acid Chemical Properties,Uses,Production

    Pharmacological action

    Chlorogenic acid is also called "green" auspicious acid, tannins "coffee", "coffee tannic acid", is a plant produce a styrene acrylic compounds through shikimic acid hitches in aerobic respiration process.It is coffee acyl quinic acid derivatives.The oxidation resistance is strong, and also has the anti HIV, anti tumor cells, antibacterial, improve central excited, cholagogue function.It has teratogenic, allergy and regulate the activity of cytochrome P450 ligase, and other functions.It is widely exist in more content honeysuckle plants. It is obtained by the water needle crystal, and it is the hemihydrate, when 110 ℃ it is to hydrate. Melting point is 208 ℃, [a] D25 33.5 ° (water, C = 1), K = 2.2 x 10-3 (27 ℃).It is weak acidity and convergence. When 25 ℃ , the solubility in water is 4%, easily soluble in hot water, but soluble in ethanol, acetone, slightly soluble in ethyl acetate, insoluble in chloroform, ether and carbon disulfide. It is azeotropic with concentrated hydrochloric acid and come to blue dye. It can make the bromine water fade, It is azeotropic with strong hydrogen iodide and obtain benzoic acid, It is obtained phenol by thermal decomposition together with water at 230 ℃, It decomposite to caffeic acid and quinic acid with dilute hydrochloric acid, and caffeic acid and quinic acid with dilute alkali at room temperature. Chlorogenic acid and its isomer different chlorogenic acid and green chlorogenic acid are in fruits of dicotyledonous plants, leaves, and other organizations,which is an important factor for plant metabolism. Chlorogenic acid has good biological activity, the transparent acid enzyme and inhibition of glucose-6-phosphatase, free radical lipid perxidation qing mutagenesis resistance and cardiovascular crown reinforcement, special efficacy in lipid-lowering, both anti-bacterial anti-virus, protecting liver cholagogic.
    Chlorogenic acid as the condensation product of caffeic acid and quinic acid, is blue when meeting with iron, which is similar to tannins , but not precipitated with protein, so no convergence. Caffeic acid and chlorogenic acid has the wide bacteriostasis, but can be inactivated protein in the body. This product is similar to caffeine, oral or intraperitoneal injection, can improve the rat central excitability. Oral the drug of chlorogenic acid and coffee acid can increase the amount of hydrochloric acid secretion in the stomach, and can make slow pulse, and quinic acid is not. Chlorogenic acid could significantly increase small intestine peristalsis on the rat or mouse. Chlorogenic acid, caffeic acid and quinic acid can increase the tension of rat uterus, this function can be cancelled by papaverine, while atropine can't influence. Caffeic acid, chlorogenic acid, also can promote bile secretion in rats. On the specimens of rabbit ileum in vitro, this product can enhance the effect of adrenaline, but has no effect on blood glucose of adrenaline.

    Protecting liver, gallbladder

    Chlorogenic acid in flos lonicerae has favorable gallbladder function, promoting biliary Secretion of rats. Injection of 200 mg/kg chlorogenic acid to browns MAO honeysuckle total saponins subcutaneous can be significantly against CCl4, paracetamol and the increase of serum GPT caused by galactosamine in mice liver and liver triglyceride levels, and significantly reduce the severity of the liver pathological damage, making dot necrosis number sum and necrosis occur rate liver decreased obviously.

    The inhibitory effect on hyaluronidase and glucose - 6 - phosphatase

    Hyaluronic cranberry (HAase) is one of the cracking mucopolysaccharide enzymes, can catalyze hyaluronic acid (HA) decomposition,which is in relation to the permeability of vascular system and inflammation. HA is a mucopolysaccharide, which is composed of uronic acid and acetyl glucosamine, having a variety of functions, such as heal, make the skin wetting health, lubricating joints and prevent inflammation, etc. 3, 5-2 coffee acyl quinic acid (artichoke acid) and chlorogenic acid found in the ethyl acetate extract from the narrow assists cone flower (Echinacea amgustifolia DC) roots have stronger inhibitory effect of HAase activated. Animal in vitro studies have demonstrated that chlorogenic acid can not reversible inhibition of glucose-6-hydrolysis of phosphatase, reduce liver glycogen decomposition and exogenous glucose absorption. Animal studies have shown that the use of chlorogenic acid can reduce high blood sugar spikes caused by the use of glucagon (glycogenolysis). Therefore, chlorogenic acid can lower blood sugar level, improve the liver glucose-6-phosphoric acid and the concentration of hepatic glycogen.

    The character of molecular structure

    Chlorogenic acid is formed by caffeic acid and quinic acid, and the molecular structure has ester bond, unsaturated double bond and polyphenol unstable part of the three. In the process of extracted from plants, chlorogenic acid often happen by hydrolysis and intramolecular ester base migration isomerization . Due to the special structure of chlorogenic acid, it can extract from plants by the polarity solvent such as ethanol, acetone, methanol. But due to the instability of chlorogenic acid itself, extraction can not be in high temperature, strong light and heat for a long time. Chlorogenic acid liquid were placed in brown bottle, refrigerator (2 ℃) to save to be the most stable.

    Preparation method

    It can be obtained by (1S)-1-ethoxyformyloxy-3-cis-[3,4-dihydroxy-anti-cinnamoyl oxygen radicals]-4'-anti-5'-anti-dihydroxy cyclohexane-γ-methyl formate with barium hydroxide in methanol catalytic hydrolysis, or by the segregation from green coffee beans.

    HPLC method for determination the content

    (1)Chromatographic conditions: octadecyl silane bonded silica gel as the filling agent; Acetonitrile-0.4% phosphoric acid solution (13:87) as mobile phase; Detection wavelength of 327 nm. Theoretical plate number according to the chromatographic peak of chlorogenic acid is greater than 1000. (2)the preparation of the reference substance solution: precisely weigh the right amount of chlorogenic acid reference substance, placed in brown volumetric flask, adding 50% methanol solution containing 40 μg /mL (saving below 10 ℃). (3)the preparation of sample solution: taking samples of dry powder is about 0.5 g, precision said, with a plug in the conical flask, adding 50 ml 50% methanol , 30 min ultrasonic processing , cooling, weighing, make up the weight loss reduction with 50% methanol, shake well, filtration, abandoned the early filtrate, precision measuring duration of filtrate 5 ml, 25 ml volumetric brown flask , add 50% methanol to the scale, shake well. (4)assimilate precision respectively from each 10 μL reference substance and the sample solution, injection liquid chromatograph, determination,obtained.

    Toxicity

    Chlorogenic acid is sensitive to people, can cause asthma, dermatitis, but no this reaction to the oral of chlorogenic acid. It can be active no sensitization substances by small intestinal secretions convertion to. The toxicity of chlorogenic acid is very small, LD50 is greater than 1 g/kg to young rats, intraperitoneal injection of greater than 0.25 g/kg.

    Chemical property

    Hemihydrate is needle crystal (water). When 110 ℃, it become to anhydrous compounds. Melting point: 208 ℃, [alpha] 20D-35.2 (C = 2.8). When 25 ℃, water solubility was 4%, solubility is bigger in the hot water. Soluble in ethanol and acetone, slightly soluble in ethyl acetate.

    Uses

    It has broad antibacterial effect, advantageous bravery, hemostatic, increase white blood cell and antiviral effect, the effect of the blood clotting and bleeding time is shortened. It is used in the treatment of upper respiratory tract infection, anti-inflammatory and antipyretic, cool blood heat dissipation. Used as pharmaceutical raw materials and intermediates. clearing heat and removing toxicity, cold wind heat, broad-spectrum antimicrobial properties, having obvious inhibitory effect to hemolytic streptococcus, dysentery rod gas and salmonella typhi bacteria

    Category

    Toxic substances

    Toxicity grading

    toxication

    Acute toxicity

    Abdominal cavity-rat LDL0:4000 mg/kg

    Flammability hazard characteristics

    Combustible; Release acrid smoke fire

    Storage and transport properties

    Low temperature warehouse, ventilated, dry

    Fire extinguishing agent

    Water, carbon dioxide, dry powder, sand

    Chemical Properties

    white to slightly yellowish-beige powder

    Uses

    antioxidant, free radical scavenger

    Uses

    A major component of green coffee the extracts of which promote weight loss in overweight and obese people. Chlorogenic Acid is an important intermediate in lignin biosynthesis. Chlorogenic Acid is an antioxidant and an inhibitor of the tumor promoting activity of phorbol ester. It has protective effect against streptozotocin-nicotinamide generated oxidative stress induced diabetes and may also pr otect against cardiovascular disease.

    Purification Methods

    Crystallise the acid from water and dry it at 110o. [Beilstein 10 H 537, 10 I 271, 10 II 378, 10 III 2408, 10 IV 2259.]

    Chlorogenic acid Preparation Products And Raw materials

    Raw materials

    Preparation Products


    Chlorogenic acid Suppliers

    Global( 528)Suppliers
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    Shaanxi Pioneer Biotech Co., Ltd .
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    Shanghai Standard Technology Co., Ltd.
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    View Lastest Price from Chlorogenic acid manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2021-10-08 Chlorogenic acid
    327-97-9
    US $0.00 / KG 1g 98% 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
    2021-09-26 Chlorogenic acid 327-97-9
    327-97-9
    US $38.50 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
    2021-08-26 Chlorogenic Acid
    327-97-9
    US $11.00 / ASSAYS 1ASSAYS 99% 10000kg Hebei Crovell Biotech Co Ltd

    Chlorogenic acid Spectrum


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