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    Caffeic acid

    Physical and Chemical Properties Extraction Method Drugs for white blood cells increase HPLC determination of caffeic acid in dandelion Chemical Properties Uses Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
    Caffeic acid
    Caffeic acid structure
    CAS No.
    Chemical Name:
    Caffeic acid
    Caffeic;31-39-5;NSC 623438;CAFFIC ACID;CAFFEIC ACID;AKOS B004050;Caffeic acid 0;cis-caffeicaci;Caffeicacid,96%;CaffeicAcidPure
    Molecular Formula:
    Formula Weight:
    MOL File:

    Caffeic acid Properties

    Melting point:
    211-213 °C (dec.) (lit.)
    Boiling point:
    272.96°C (rough estimate)
    1.2933 (rough estimate)
    refractive index 
    1.4500 (estimate)
    storage temp. 
    ethanol: 50 mg/mL
    yellow to tan
    Water Solubility 
    soluble in hot water
    Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
    CAS DataBase Reference
    331-39-5(CAS DataBase Reference)
    EWG's Food Scores
    2B (Vol. 56) 1993
    Proposition 65 List
    Caffeic Acid
    NCI Drug Dictionary
    caffeic acid
    NIST Chemistry Reference
    Cinnamic acid, 3,4-dihydroxy-(331-39-5)
    EPA Substance Registry System
    2-Propenoic acid, 3-(3,4-dihydroxyphenyl)- (331-39-5)
    • Risk and Safety Statements
    Signal word  Warning
    Hazard statements  H315-H319-H335-H351-H361
    Precautionary statements  P201-P202-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P308+P313-P405-P501-P501a-P261-P281-P305+P351+P338-P280
    Hazard Codes  Xn,Xi
    Risk Statements  36/37/38-40-63-68
    Safety Statements  26-36/37/39-36
    WGK Germany  3
    RTECS  GD8950000
    Hazard Note  Irritant
    HS Code  29182990
    NFPA 704
    2 0

    Caffeic acid price More Price(62)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 8.22029 3,4-Dihydroxycinnamic acid for synthesis 331-39-5 10 g $61.97 2021-12-16 Buy
    Sigma-Aldrich 60018 Caffeic acid matrix substance for MALDI-MS, ≥99.0% (HPLC) 331-39-5 1g $99.5 2021-12-16 Buy
    Sigma-Aldrich 51868 trans-Caffeic acid certified reference material, TraceCERT? 331-39-5 50 mg $100 2021-12-16 Buy
    Sigma-Aldrich 205546 Caffeic Acid 331-39-5 500mg $74.92 2021-12-16 Buy
    TCI Chemical C0002 Caffeic Acid >98.0%(T) 331-39-5 5g $28 2021-12-16 Buy

    Caffeic acid Chemical Properties,Uses,Production

    Physical and Chemical Properties

    Caffeic acid, scientific name: "3-(3,4-dihydroxyphenyl)-2-propenoic acid." Molecular formula: C9H8O4; the molecular weight: 180.16. It is presented in plants such as coffee in the form of chlorogenic acid. It is yellow crystals with melting point being 223~225 °C. When it is precipitated in concentrated solution, it contains no crystal water. However, precipitate of crystals from dilute solution contains one molecule of crystallized water. It is slightly soluble in water, and easily soluble in hot water, cold ethanol, and ethyl acetate. Its alkaline solution is orange and exhibits dark green when being mixed with ferric chloride.
    Application: caffeic acid is safe to be applied in cosmetics and has a broader antibacterial and antiviral activity. It can also absorb ultraviolet radiation. A low concentration of it already has inhibitory efficacy on the generation of skin melanin. Its applied amount in the beauty products for whitening is at the range of 0.5 to 2%. It can also be used as additive for the oxidized hair dyes which is good for enhancing the strength of the color.
    Preparation: it can be produced from the Perkin’s reaction between protocatechuic aldehyde and acetic acid,As follows:
    Reaction formula

    Extraction Method

    Caffeic acid belongs to common phenolic compounds with effects of increasing the levels of white blood cells. It is easily to be confused with caffeine and is widely distributed in the plant kingdom. Its major plant sources include lemon peel, Ranunculaceae cimicifuga rhizome, and valerian root. Caffeic acid, together with ferulic acid, erucic acid, and p-hydroxy cinnamic acid are ubiquitous hydroxy cinnamic acid-class molecule distributed in various kinds of plants. This kind of products has conjugated double bonds in the side chain of the molecular structure, and thus exhibiting significant fluorescence upon ultraviolet light, mostly showing bluish color fluorescence. This is a advantage for paper chromatography tests or thin layer chromatography tests.
    Extraction Method: Single spike cimicifuga rhizome is extracted with methanol which is removed through concentration under reduced pressure. Add hot water to the residue to dissolve it. Heating the water to dissolve the residue, and further filter the insolubles upon heating. After cooling, add benzene for extraction with the benzene solution being washed with 1% aqueous sodium bicarbonate and further collecting the washed solution. Add dilute hydrochloric acid for acidification, and then apply benzene to remove the free organic acid; Concentrate under reduced pressure to get rid of the benzene with the residue being the enriched product of caffeic acid.
    The above information is edited by the chemicalbook of Dai Xiongfeng.

    Drugs for white blood cells increase

    Caffeic acid is a kind of drugs for stopping bleeding as well as increasing the number of white blood cell with effects of contracting microvascular coagulation, improving the function of coagulation factors, and increasing white blood cells and platelets. It is suitable for preventing bleeding or stopping bleeding in surgeries as well as for stopping bleeding for bleeding diseases in internal medicine, and obstetrics and gynecology. It is also suitable for treating leukopenia and thrombocytopenia caused by a variety of reasons.

    HPLC determination of caffeic acid in dandelion

    [For the test] Compositae dandelion: Taraxacum mongolicum Hand. Mazz, Alkali land dandelion T. sinicum Kitag.
    (1) Chromatographic conditions: take octadecylsilane silica gel as a filling agent; methanol-phosphate buffer (sodium dihydrogen phosphate 1.56g, add water to dissolve it in 1000 ml, add 1% of phosphoric acid solution for adjusting to pH 3.8 to 4.0, that’s it) (23:77) as the mobile phase; detection wavelength is 323 nm; column temperature should be 40 °C. Number of theoretical plates should be calculated according to the caffeic acid peak and should not be less than 3,000.
    (2) the preparation of the reference solution: take 7.5 mg of caffeic acid reference substance, accurately weigh it and transfer it into the 50ml volumetric flask; add methanol to certain scale, shake; take precise amount of 2ml and put into 10ml volumetric flask, add methanol to the scale , shake, to obtain the reference solution (containing caffeic acid 30μg per ml).
    (3) Preparation of sample solution: Take about 1 g of medicine powder, accurately weigh it, and put it in 50ml Erlenmeyer flask, precisely add 10 mL of methanol solution containing 5% formic acid, seal, shake, weigh, and subject to ultrasonic treatment for 30min, remove, cool, then weigh again; use the methanol solution of 5% formic acid to complement the weight loss, shake, centrifuge, and take the supernatant for being filtrated through microporous membrane (0.45μm) with the filtrate being placed in brown bottle to obtain the sample solution.
    (4) Determination: separately and precisely pipette 10μl of both reference solution and sample solution and transfer into the liquid chromatography for measurement.
    (5) Measurement results: calculated from the dry products of dandelion herbs, the caffeic acid content should not be less than 0.02%.

    Chemical Properties

    It is yellow crystals and can be dissolved in water and ethanol.


    1. Reagents for Organic Synthesis. 2. Intermediate of caffeic acid; can be used in organic synthesis. 3. Used for Biochemical studies.


    Toxic Chemicals

    Toxicity grading


    Acute toxicity

    Intraperitoneal administration-rat LDL0: 1500 mg/kg

    Flammability and hazard characteristics

    Thermal decomposition causes irritating smoke

    Storage Characteristics

    Treasury: ventilation low-temperature and dry.

    Extinguishing agent

    Water, powder, CO2, foam.


    Caffeic acid is abundant in the whole plant of Solidago decurrens Lour. (Yi Zhi Huang Hua), fruit of Crataegus pinnatifida Bge. var. major N.E.Br. (Shan Li Hong), Salix myrtillacea Anderss. (Po Liu), rhizome of Cimicifuga foetida L., rhizome of Polypodiaceae Polypodium vulgare L. (Ou Ya Shui Long Gu), peel of Rutaceae Citrus limonum (Ning Meng), the whole plant of Polygonaceae Polygonum aviculare L. (Pian Xu), root of Valeriana officinalis L. (Xie Cao), the whole plant of Thymus mongolicus Ronn (She Xiang), leaves of Eucommia ulmoides (Du Zhong), and other herbal plants. It is a kind of polyhydroxy styrene acid, with the general chemical properties of phenolic acid. It is easily oxidized for the reason of the unsaturated double bonds, particularly unstable in alkaline solution
    Caffeic acid has both cis and trans isomers, and the two isomers of caffeic acid have a mutual transformation in plants, which may regulate some important physiological process. Caffeic acid exists in plants in the main form of complexes; free state accounts for a few proportion.


    Caffeic acid is an inhibitor of 5-LO with an IC50 value of 3.7-72 μM and 12-LO with an IC50 value of 5.1-30 μM.

    Chemical Properties

    Light yellow to greenish-yellow powder

    Physical properties

    Appearance: yellow crystal. The crystal from the concentrated solution does not contain crystal water, and the crystal from the dilute solution contains one molecule crystal water. Melting point: 223?225?°C. Solubility: It is slightly soluble in cold
    water but soluble in hot water, cold ethanol, and ethyl acetate. The basic solution is orange-red. Ferric chloride solution was dark green.


    Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis. It has also been used to determine its antioxidant activity by various assay methods.


    antineoplastic, PGE2 synthase inhibitor, PK inhibitor


    Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi.


    It is used for preventing or stopping bleeding during surgery, as well as hemostasis in the department of medicine, obstetrics and gynecology, etc. It is also used for various causes of neutropenia and thrombocytopenia.

    General Description

    Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.

    Air & Water Reactions

    Insoluble in water.

    Reactivity Profile

    Caffeic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Caffeic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

    Health Hazard

    ACUTE/CHRONIC HAZARDS: When heated to decomposition Caffeic acid emits acrid smoke and fumes.

    Fire Hazard

    Flash point data for Caffeic acid are not available; however, Caffeic acid is probably combustible.

    Biochem/physiol Actions

    A natural dietary phenolic compound found in plants that is an anti-oxidant. Inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy. Inhibits Cu2+-induced LDL oxidation.

    Purification Methods

    Recrystallise this antioxidant from water. [Beilstein 10 IV 1776.]

    Caffeic acid Preparation Products And Raw materials

    Raw materials

    Preparation Products

    Caffeic acid Suppliers

    Global( 555)Suppliers
    Supplier Tel Fax Email Country ProdList Advantage
    Hangzhou Viablife Biotech Co., Ltd.
    +1 435-5570519 01-435-5570519
    86-571-88766836 info@viablife.com CHINA 12 58
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    info@dakenchem.com China 15426 58
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    2022-01-24 Caffeic acid
    US $0.00 / Kg/Drum 1Kg/Bag 99% 200mt Jinan Finer Chemical Co., Ltd
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    Caffeic acid Spectrum

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