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    Ethyl acetate

    organic ester compound Chemical Properties Purification and water removal methods Uses Production Extinguishing agent Professional standards
    Ethyl acetate
    Ethyl acetate structure
    CAS No.
    141-78-6
    Chemical Name:
    Ethyl acetate
    Synonyms
    ETOH;EtOAc;Etile;SPIRIT;Ethyle;ALCOHOL;Vinasse;Acetidin;ai3-00404;FEMA 2414
    CBNumber:
    CB7255315
    Molecular Formula:
    C4H8O2
    Formula Weight:
    88.11
    MOL File:
    141-78-6.mol

    Ethyl acetate Properties

    Melting point:
    −84 °C(lit.)
    Boiling point:
    76.5-77.5 °C(lit.)
    Density 
    0.902 g/mL at 25 °C(lit.)
    vapor density 
    3 (20 °C, vs air)
    vapor pressure 
    73 mm Hg ( 20 °C)
    refractive index 
    n20/D 1.3720(lit.)
    FEMA 
    2414 | ETHYL ACETATE
    Flash point:
    26 °F
    storage temp. 
    Store at +2°C to +25°C.
    solubility 
    Miscible with ethanol, acetone, diethyl ether and benzene.
    form 
    Liquid
    pka
    16-18(at 25℃)
    color 
    APHA: ≤10
    Specific Gravity
    0.902 (20/20℃)
    Relative polarity
    0.228
    Odor
    Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm)
    Odor Threshold
    0.87ppm
    explosive limit
    2.2-11.5%, 38°F
    Water Solubility 
    80 g/L (20 ºC)
    λmax
    λ: 256 nm Amax: ≤1.00
    λ: 275 nm Amax: ≤0.05
    λ: 300 nm Amax: ≤0.03
    λ: 325-400 nm Amax: ≤0.005
    Merck 
    14,3757
    JECFA Number
    27
    BRN 
    506104
    Henry's Law Constant
    0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005)
    Exposure limits
    TLV-TWA 400 ppm (~1400 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH).
    Stability:
    Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
    InChIKey
    XEKOWRVHYACXOJ-UHFFFAOYSA-N
    FDA 21 CFR
    173.228; 175.320; 177.1200; 182.60; 310.545; 73.1
    CAS DataBase Reference
    141-78-6(CAS DataBase Reference)
    Substances Added to Food (formerly EAFUS)
    ETHYL ACETATE
    EWG's Food Scores
    1
    FDA UNII
    76845O8NMZ
    NCI Dictionary of Cancer Terms
    alcohol
    NCI Drug Dictionary
    alcohol
    NIST Chemistry Reference
    Ethyl acetate(141-78-6)
    EPA Substance Registry System
    Ethyl acetate (141-78-6)
    Cosmetics Info
    Ethyl Acetate
    SAFETY
    • Risk and Safety Statements
    Symbol(GHS) 
    GHS02,GHS06,GHS08,GHS07
    Signal word  Danger
    Hazard statements  H320-H225-H301+H311+H331-H370-H319-H336
    Precautionary statements  P233-P240-P241+P242+P243-P264-P270-P271-P303+P361+P353-P304+P340+P312-P305+P351+P338+P337+P313-P307+P311-P403+P233-P405-P501-P210-P260-P280-P301+P310-P311-P261-P305+P351+P338-P370+P378-P403+P235-P501a
    Hazard Codes  F,Xi,Xn,T
    Risk Statements  11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
    Safety Statements  16-26-33-36/37-45-7-25
    RIDADR  UN 1173 3/PG 2
    WGK Germany  1
    RTECS  AH5425000
    1
    Autoignition Temperature 427 °C
    TSCA  Yes
    HS Code  2915 31 00
    HazardClass  3
    PackingGroup  II
    Toxicity LD50 orally in rats: 11.3 ml/kg (Smyth)
    NFPA 704
    3
    1 0

    Ethyl acetate price More Price(209)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich E-029 Ethanol-50 50?mg/dL in H2O, ampule of 10 × 1.2?mL, certified reference material, Cerilliant? 141-78-6 10 x 1.2 mL $40.6 2021-03-22 Buy
    Sigma-Aldrich E-040 Ethanol-10 10?mg/dL in H2O, pack of 10 × 1.2 mL?ampules, certified reference material, Cerilliant? 141-78-6 10 x 1.2 mL $40.6 2021-03-22 Buy
    Sigma-Aldrich E-045 Ethanol-40 40?mg/dL in H2O, ampule of 10 × 1.2?mL, certified reference material, Cerilliant? 141-78-6 10 x 1.2 mL $40.6 2021-03-22 Buy
    Sigma-Aldrich E-041 Ethanol-150 150?mg/dL in H2O, ampule of 10 × 1.2?mL, certified reference material, Cerilliant? 141-78-6 10 x 1.2 mL $40.6 2021-03-22 Buy
    Sigma-Aldrich E-035 Ethanol-25 25?mg/dL in H2O, ampule of 10 × 1.2?mL, certified reference material, Cerilliant? 141-78-6 10 x 1.2 mL $40.6 2021-03-22 Buy

    Ethyl acetate Chemical Properties,Uses,Production

    organic ester compound

    Ethyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
    Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.

    ethyl acetate structure

    Chemical Properties

    Ethyl acetate (structure shown above) is the most familiar ester to many chemistry students and possibly the ester with the widest range of uses. Esters are structurally derived from carboxylic acids by replacing the acidic hydrogen by an alkyl or aryl group. Ethyl acetate itself is a colourless liquid at room temperature with a pleasant "fruity" smell, b.p. 77°C.
    Ethyl acetate
    Ethyl acetate has many uses, such as artificial fruit essences and aroma enhancers, artificial flavours for confectionery, ice cream and cakes, as a solvent in many applications (including decaffeinating tea and coffee) for varnishes and paints (nail varnish remover), and for the manufacture of printing inks and perfumes.

    Purification and water removal methods

    Ethyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.

    Uses

    Industry
    Applications
    Role/Benefit
    Flavor and essence
    Food flavor
    Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
    Alcoholic essence
    Used slightly as fragrance volatile
    Perfume essence
    Used slightly as fragrance volatile
    Chemical manufacture
    Production of acetamide, acetyl acetate, methyl heptanone, etc
    Organic chemical raw materials
    Production of organic acid
    Extracting agent
    Laboratory
    Dilution and extraction
    Supply excellent dissolving capacity
    Chromatographic analysis
    Standard material
    Column chromatography and extractions
    Main component of mobile phase
    Reaction solvent
    Be prone to hydrolysis and transesterification
    Chemical analysis
    Thermometer calibration for sugar separation
     Standard material
    Determination of bismuth, boron, gold, molybdenum, platinum and thallium
    Solvent
    Entomology
    Insect collecting and study
    Used as effective asphyxiant to kill the collected insect quickly without destroying it
    Textile industry
    Cleaning agent
    Supply excellent dissolving capacity
    Printing
    Flexographic and rotogravure printing
    Dissolve the resin, control the viscosity and modify the drying rate
    Electronics industry
    Viscosity reducer
    Reduce the viscosity of resins used in photoresist formulations
    Paint manufacture
    Solvent
    Dissolve and dilute the paints
    Health & personal care products
    The formulation of nail polish, nail polish removers and other manicuring products
    Supply excellent dissolving capacity
    Pharmaceutical
    Medicine manufacturing
    Extraction agent; intermediate
    Cosmetics
    Aroma enhancer
    In perfume to enhance aroma
    Others
    Tanning extracts
    Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
    Production of adhesive
    Solvent
    Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution
    Extracting agent

    Production

    Industrial production of ethyl acetate is mainly classified into three processes.

    The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
    CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
    The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

    The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
    2 CH3CHO → CH3COOC2H5
    This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

    The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
    CH2= CH2 + CH3COOH → CH3COOC2H5 
    The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
    In such circumstances, an improved process of ethyl acetate production is strongly desired.

    Extinguishing agent

    dry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent

    Professional standards

    TWA 1400 mg/m3; STEL 2000 mg/m3

    Description

    Ethyl acetate (systematically, ethyl ethanoate, commonly abbreviated EtOAc or EA) is the organic compound with the formula CH3COOCH2CH3. This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, decaffeinating tea and coffee, and cigarettes (see list of additives in cigarettes). Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent. The combined annual production in 1985 of Japan, North America, and Europe was about 400,000 tons. In 2004, an estimated 1.3M tons were produced worldwide.

    Chemical Properties

    Ethyl acetate has a pleasant ethereal fruity, brandy-like odor, reminiscent of pineapple, somewhat nauseating in high concentration. It has fruity sweet taste when freshly diluted in water. Ethyl acetate is probably one of the most used of all flavor chemicals by volume. Ethyl acetate is slowly decomposed by moisture and then acquires an acid status due to the acetic acid formed.

    Physical properties

    Clear, colorless, mobile liquid with a pleasant, sweet fruity odor. Experimentally determined detection and recognition odor threshold concentrations were 23 mg/m3 (6.4 ppmv) and 48 mg/m3 (13.3 ppmv), respectively (Hellman and Small, 1974). Cometto-Mu?iz and Cain (1991) reported an average nasal pungency threshold concentration of 67,300 ppmv.

    Occurrence

    Although it has been reported present in some natural fruital aromas and in some distillates (rum, rum ether), it has not been reported yet as a constituent of essential oils; it has been identified also in the petals of Magnolia fuscata. Reported found in many foods including fresh and cooked apple, apricot, banana (169 ppm), sweet and sour cherry, citrus peel oils and juices, blueberry, cranberry, black currants, raspberry, blackberry, guava, passion fruit, melon, peaches, papaya, pineapple, cabbage, onion, leek, potato, tomato (3 to 6 ppm), clove, ginger, vinegar, breads, cheeses (0.2 to 0.8 ppm), butter (2 ppm), yogurt, milk, meats, cognac, beer (4 to 64 ppm), whiskies, cider, sherry, grape wines, rum, cocoa, coffee, tea, filberts, peanuts, popcorn, oats, honey, soybeans, coconut, olive oil (0.02 ppm) and olive.

    Uses

    Ethyl acetate is used as a solvent for varnishes, lacquers, and nitrocellulose; as anartificial fruit flavor; in cleaning textiles;and in the manufacture of artificial silk andleather, perfumes, and photographic filmsand plates (Merck 1996). Ethyl Acetate is generally used as a solvent in organic reactions. Environmental contaminants; Food contaminants.

    Uses

    Ethyl acetate is used primarily as a solvent and diluent, being favored because of its low cost, low toxicity, and agreeable odor. For example, it is commonly used to clean circuit boards and in some nail varnish removers (acetone and acetonitrile are also used). Coffee beans and tea leaves are decaffeinated with this solvent.It is also used in paints as an activator or hardener.[citation needed] Ethyl acetate is present in confectionery, perfumes, and fruits. In perfumes, it evaporates quickly, leaving only the scent of the perfume on the skin.
    3 – 1 - Laboratory uses
    In the laboratory, mixtures containing ethyl acetate are commonly used in column chromatography and extractions. Ethyl acetate is rarely selected as a reaction solvent because it is prone to hydrolysis and trans esterification.
    3 – 2 - Occurrence in wines
    Ethyl acetate is the most common ester in wine, being the product of the most common volatile organic acid — acetic acid, and the ethyl alcohol generated during the fermentation. The aroma of ethyl acetate is most vivid in younger wines and contributes towards the general perception of "fruitiness" in the wine.
    3 – 3 - Entomological killing agent
    In the field of entomology, ethyl acetate is an effective asphyxiant for use in insect collecting and study. In a killing jar charged with ethyl acetate, the vapors will kill the collected (usually adult) insect quickly without destroying it. Because it is not hygroscopic, ethyl acetate also keeps the insect soft enough to allow proper mounting suitable for a collection.

    Uses

    Pharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.

    Production Methods

    Ethyl acetate can be manufactured by the slow distillation of a mixture of ethanol and acetic acid in the presence of concentrated sulfuric acid. It has also been prepared from ethylene using an aluminum alkoxide catalyst.

    Production Methods

    Ethyl acetate is synthesized in industry mainly via the classic Fischer esterification reaction of ethanol and acetic acid. This mixture converts to the ester in about 65% yield at room temperature:
    CH3CH2OH + CH3COOH ? CH3COOCH2CH3 + H2O
    The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water. It is also prepared in industry using the Tishchenko reaction, by combining two equivalents of acetaldehyde in the presence of an alkoxide catalyst:
    2 CH3CHO → CH3COOCH2CH3.

    Preparation

    Ethyl acetate is made by esterification of acetic acid with ethanol, from acetaldehyde, or by the direct addition of ethylene to acetic acid. BP started a 220,000 tonne/year plant in 2001 to operate the last of these processes, known as AVADA. Ethylene and acetic acid react in the presence of a heteropolyacid catalyst to give ethyl acetate at a claimed high selectivity and 99.97% purity. This is the world’s largest ethyl acetate plant and is motivated by its increasing use as a more “acceptable” solvent than hydrocarbons.
    In some countries, where ethanol is expensive or there is surplus acetaldehyde capacity, ethyl acetate is made by a Tishchenko reaction. Sasol in South Africa was said to be investigating such a process in the early 2000s. Ethanol is a solvent for surface coatings, cleaning preparations, and cosmetics. Industrial ethanol is aerobically fermented to white vinegar (dilute acetic acid) of the type used for pickling. Gourmet vinegars—wine vinegar, cider vinegar, and so on, made by fermentation of alcoholic beverages—are also available. Ten percent of industrial ethanol production was used for vinegar in the United States in 2001.

    Reactions

    Ethyl acetate can be hydrolyzed in acidic or basic conditions to regain acetic acid and ethanol. The use of an acid catalyst accelerates the hydrolysis, which is subject to the Fischer equilibrium mentioned above. In the laboratory, and usually for illustrative purposes only, ethyl esters are typically hydrolyzed in a two step process starting with a stoichiometric amount of strong base, such as sodium hydroxide. This reaction gives ethanol and sodium acetate, which is unreactive toward ethanol:
    CH3CO2C2H5 + Na OH → C2H5OH + CH3CO2Na
    The rate constant is 0.111 dm3 / mol.sec at 25 °C.

    Aroma threshold values

    Detection: 5 ppb to 5 ppm

    Air & Water Reactions

    Highly flammable. Slightly soluble in water. Ethyl acetate is slowly hydrolyzed by moisture.

    Reactivity Profile

    Ethyl acetate is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. Ethyl acetate may ignite or explode with lithium aluminum hydride. Ethyl acetate may also ignite with potassium tert-butoxide. Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids. Ethyl acetate will attack some forms of plastics, rubber and coatings. Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as Ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).

    Health Hazard

    The acute toxicity of ethyl acetate is low. Ethyl acetate vapor causes eye, skin, and respiratory tract irritation at concentrations above 400 ppm. Exposure to high concentrations may lead to headache, nausea, blurred vision, central nervous system depression, dizziness, drowsiness, and fatigue. Ingestion of ethyl acetate may cause gastrointestinal irritation and, with larger amounts, central nervous system depression. Eye contact with the liquid can produce temporary irritation and lacrimation. Skin contact produces irritation. Ethyl acetate is regarded as a substance with good warning properties. No chronic systemic effects have been reported in humans, and ethyl acetate has not been shown to be a human carcinogen, reproductive, or developmental toxin

    Flammability and Explosibility

    Ethyl acetate is a flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Ethyl acetate vapor forms explosive mixtures with air at concentrations of 2 to 11.5% (by volume). Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide. Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires.

    Chemical Reactivity

    Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

    Pharmaceutical Applications

    In pharmaceutical preparations, ethyl acetate is primarily used as a solvent, although it has also been used as a flavoring agent. As a solvent, it is included in topical solutions and gels, and in edible printing inks used for tablets.
    Ethyl acetate has also been shown to increase the solubility of chlortalidone and to modify the polymorphic crystal forms obtained for piroxicam pivalate, mefenamic acid, and fluconazole,and has been used in the formulation of microspheres. Ethyl acetate has been used as a solvent in the preparation of a liposomal amphotericin B dry powder inhaler formulation.(9) Its use as a chemical enhancer for the transdermal iontophoresis of insulin has been investigated.
    In food applications, ethyl acetate is mainly used as a flavoring agent. It is also used in artificial fruit essence and as an extraction solvent in food processing.

    Safety Profile

    Potentially poisonous by ingestion. Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant. A flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials. Moderate explosion hazard. See ETHANOL, METHYL ALCOHOL, and n-PROPYL ALCOHOL.

    Safety

    Ethyl acetate is used in foods, and oral and topical pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
    However, ethyl acetate may be irritant to mucous membranes, and high concentrations may cause central nervous system depression. Potential symptoms of overexposure include irritation of the eyes, nose, and throat, narcosis, and dermatitis.
    Ethyl acetate has not been shown to be a human carcinogen or a reproductive or developmental toxin.
    The WHO has set an estimated acceptable daily intake of ethyl acetate at up to 25 mg/kg body-weight.
    In the UK, it has been recommended that ethyl acetate be temporarily permitted for use as a solvent in food and that the maximum concentration consumed in food should be set at 1000 ppm.
    LD50 (cat, SC): 3.00 g/kg
    LD50 (guinea-pig, oral): 5.50 g/kg
    LD50 (guinea-pig, SC): 3.00 g/kg
    LD50 (mouse, IP): 0.709 g/kg
    LD50 (mouse, oral): 4.10 g/kg
    LD50 (rabbit, oral): 4.935 g/kg
    LD50 (rat, oral): 5.62 g/kg

    Chemical Synthesis

    By reacting acetic acid and ethanol in the presence of sulfuric acid; by distillation of sodium potassium, or lead acetate with ethanol in the presence of sulfuric acid; by polymerizatin of acetaldehyde in the presence of aluminum ethylate or aluminum acetate as catalysts.

    Potential Exposure

    This material is used as a solvent for nitrocellulose and lacquer. It is also used in making dyes,flavoring and perfumery, and in smokeless powder manufacture

    Carcinogenicity

    Ethyl acetate was not mutagenic in bacterial assays; it was not genotoxic in a number of in vivo assays but did cause chromosomal damage in hamster cells in vitro.
    Ethyl acetate has a fruity odor detectable at 10ppm.
    The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for ethyl acetate is 400pm (1440mg/m3).

    Source

    Identified among 139 volatile compounds identified in cantaloupe (Cucumis melo var. reticulates cv. Sol Real) using an automated rapid headspace solid phase microextraction method (Beaulieu and Grimm, 2001).

    Environmental Fate

    Biological. Heukelekian and Rand (1955) reported a 5-d BOD value of 1.00 g/g which is 54.9% of the ThOD value of 1.82 g/g.
    Photolytic. Reported rate constants for the reaction of ethyl acetate and OH radicals in the atmosphere (296 K) and aqueous solution are 1.51 x 10-12 and 6.60 x 10-13 cm3/molecule?sec, respectively (Wallington et al., 1988b).
    Chemical/Physical. Hydrolyzes in water forming ethanol and acetic acid (Kollig, 1993). The estimated hydrolysis half-life at 25 °C and pH 7 is 2.0 yr (Mabey and Mill, 1978).

    Metabolism

    Ethyl acetate is hydrolysed to ethyl alcohol, which is then partly excreted in the expired air and urine. The rest is metabolized, the acetate fraction becoming incor porated in the body pool (Fassett, 1963).

    storage

    Ethyl acetate should be stored in an airtight container, protected from light and at a temperature not exceeding 30°C. Ethyl acetate is slowly decomposed by moisture and becomes acidic; the material can absorb up to 3.3% w/w water.
    Ethyl acetate decomposes on heating to produce ethanol and acetic acid, and will emit acrid smoke and irritating fumes. It is flammable and its vapor may travel a considerable distance to an ignition source and cause a ‘flashback’.
    The alkaline hydrolysis of ethyl acetate has been shown to be inhibited by polyethylene glycol and by mixed micelle systems.

    Shipping

    UN1173 Ethyl acetate, Hazard Class: 3; Labels: 3-Flammable liquid.

    Purification Methods

    The most common impurities in EtOAc are water, EtOH and acetic acid. These can be removed by washing with aqueous 5% Na2CO3, then with saturated aqueous CaCl2 or NaCl, and drying with K2CO3, CaSO4 or MgSO4. More efficient drying is achieved if the solvent is further dried with P2O5, CaH2 or molecular sieves before distillation. CaO has also been used. Alternatively, ethanol can be converted to ethyl acetate by refluxing with acetic anhydride (ca 1mL per 10mL of ester), the liquid is then fractionally distilled, dried with K2CO3 and redistilled. [Beilstein 2 III 127.]

    Toxicity evaluation

    Ethyl acetate is rapidly hydrolyzed to ethanol and acetic acid. When ethyl acetate was injected intraperitoneal at 1.6 g kg-1, hydrolysis to acetic acid and ethanol occurred rapidly. The biological half-life value of the conversion of ethyl acetate to ethanol was found to be between 5 and 10 min. At doses higher than 1.6 g kg-1 in rats the rate of hydrolysis exceeded the ethanol oxidation leading to the ethanol accumulation in the vascular system.

    Incompatibilities

    Ethyl acetate can react vigorously with strong oxidizers, strong alkalis, strong acids, and nitrates to cause fires or explosions. It also reacts vigorously with chlorosulfonic acid, lithium aluminum hydride, 2-chloromethylfuran, and potassium tert-butoxide.

    Waste Disposal

    Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

    Regulatory Status

    Included in the FDA Inactive Ingredients Database (oral tablets and sustained-action tablets; topical and transdermal preparations). Included in nonparenteral medicines licensed in the UK (tablets, topical solutions, and gels). Ethyl acetate is also accepted for use in food applications in a number of countries including the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

    Ethyl acetate Preparation Products And Raw materials

    Raw materials

    Preparation Products


    Ethyl acetate Suppliers

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    View Lastest Price from Ethyl acetate manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2021-11-08 Ethyl acetate
    141-78-6
    US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
    2021-09-15 Ethyl Acetate
    141-78-6
    US $450.00 / Kg/Drum 14400KG 99.9% 500mt/month Shandong Yanshuo Chemical Co., Ltd.
    2021-08-26 Ethyl Acetate
    141-78-6
    US $8.00 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd

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