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    Methanol

    Introduction Chemical Properties Uses Methanol poisoning and First Aid Measures Reactivities of Methanol Production Toxicity evaluation Methanol gasoline
    Methanol
    Methanol structure
    CAS No.
    67-56-1
    Chemical Name:
    Methanol
    Synonyms
    CH3OH;metanol;jiachun;ACID RED;Methylol;S NO 250;Carbinol;Methanol;Metanolo;ai3-00409
    CBNumber:
    CB7854099
    Molecular Formula:
    CH4O
    Formula Weight:
    32.04
    MOL File:
    67-56-1.mol

    Methanol Properties

    Melting point:
    -98 °C(lit.)
    Boiling point:
    65.4 °C(lit.)
    Density 
    0.791 g/mL at 25 °C
    vapor density 
    1.11 (vs air)
    vapor pressure 
    410 mm Hg ( 50 °C)
    refractive index 
    n20/D 1.329(lit.)
    Flash point:
    52 °F
    storage temp. 
    2-8°C
    solubility 
    benzene: miscible(lit.)
    form 
    Liquid Free From Particulates
    pka
    15.2(at 25℃)
    Specific Gravity
    0.793 (20/20℃)
    color 
    <10(APHA)
    Odor
    Faint alcohol odor detectable at 4 to 6000 ppm (mean = 160 ppm)
    Relative polarity
    0.762
    Relative density, gas (air=1)
    1.1
    Odor Threshold
    33ppm
    explosive limit
    5.5-44%(V)
    Water Solubility 
    miscible
    λmax
    λ: 210 nm Amax: 0.50
    λ: 220 nm Amax: 0.30
    λ: 230 nm Amax: 0.15
    λ: 235 nm Amax: 0.10
    λ: 240 nm Amax: 0.05
    λ: 260 nm Amax: 0.01
    λ: 400 nm Amax: 0.01
    Merck 
    14,5957
    BRN 
    1098229
    Henry's Law Constant
    4.99 at 25 °C (headspace-GC, Gupta et al., 2000)
    Exposure limits
    TLV-TWA (200 ppm) (ACGIH), 260mg/m3, 1040mg/m3 (800 ppm) 15minutes (NIOSH); STEL 310mg/m3 (250 ppm); IDLH 25,000 ppm (NIOSH).
    FDA 21 CFR
    175.105; 175.300; 176.180; 176.200; 177.2460; 177.2800; 73.345; 73.615
    CAS DataBase Reference
    67-56-1(CAS DataBase Reference)
    Substances Added to Food (formerly EAFUS)
    METHYL ALCOHOL
    EWG's Food Scores
    2-5
    NCI Dictionary of Cancer Terms
    methanol; methyl alcohol
    FDA UNII
    Y4S76JWI15
    NIST Chemistry Reference
    Methyl alcohol(67-56-1)
    Proposition 65 List
    Methanol
    EPA Substance Registry System
    Methanol (67-56-1)
    SAFETY
    • Risk and Safety Statements
    Symbol(GHS) 
    GHS02,GHS06,GHS08,GHS07
    Signal word  Danger
    Hazard statements  H225-H301+H311+H331-H370-H319-H335-H336-H360-H372-H301-H311-H331
    Precautionary statements  P301+P310a-P501a-P201-P202-P233-P240-P241+P242+P243-P264-P270-P271-P303+P361+P353-P305+P351+P338+P337+P313-P307+P311-P405-P501-P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P260-P301+P310-P311-P301+P310+P330-P308+P311-P403+P233
    Hazard Codes  Xn,T,F
    Risk Statements  10-20/21/22-68/20/21/22-39/23/24/25-23/24/25-11-40-36-36/38-23/25
    Safety Statements  36/37-7-45-16-24/25-23-24-26
    RIDADR  UN 1170 3/PG 2
    WGK Germany  1
    RTECS  PC1400000
    3-10
    Autoignition Temperature 385 °C
    TSCA  Yes
    HS Code  2905 11 00
    HazardClass  3
    PackingGroup  II
    Toxicity LD50 oral (rat)
    5628 mg/kg
    LD50 skin (rabbit)
    15,840 mg/kg
    LC50 inhal (rat)
    >145,000 ppm (1 h)
    PEL (OSHA)
    200 ppm (260 mg/m3)
    TLV-TWA (ACGIH)
    200 ppm (260 mg/m3)—skin
    STEL (ACGIH)
    250 ppm (328 mg/m3)
    NFPA 704
    3
    1 0

    Methanol price More Price(372)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 721956 Methanol solution NMRreferencestandard,4%inmethanol-d4(99.8atom%D),NMRtubesize3?mm× 67-56-1 1 pkg $214 2021-12-16 Buy
    Sigma-Aldrich 721964 Methanol solution NMRreferencestandard,4%inmethanol-d4(99.8atom%D),NMRtubesize5?mm× 67-56-1 1 pkg $212 2021-12-16 Buy
    Sigma-Aldrich 179337 Methanol ACSreagent,≥99.8% 67-56-1 270GA $2400 2021-12-16 Buy
    Sigma-Aldrich 1.06009 Methanol for analysis EMSURE? ACS,ISO,Reag. Ph Eur 67-56-1 180 L $2895.25 2021-12-16 Buy
    Sigma-Aldrich MX0485 Methanol Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS 67-56-1 50 L $1877.75 2021-12-16 Buy

    Methanol Chemical Properties,Uses,Production

    Introduction

    Methanol is the simplest fatty alcohol. It is a colorless, flammable, irritating liquid with a boiling point of 64.7°C, a melting point of -93.90°C, and a relative density of 0.7913. Soluble in water and most organic solvents. Its severe toxicity can damage the optic nerve. Once swallowed, it can make the eyes blind and even cause death.
    Methanol has the general properties of a primary aliphatic alcohol. The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. Therefore, it is largely used in the synthesis of formaldehyde. Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and methylamine, and it is also applied as important organic solvents, extraction agents and alcohol denaturants.

    Chemical Properties

    Methanol is a clear, colorless liquid with a characteristic pungent odor (NTP NIEHS web accessed 2/16/2013). The air odor threshold has been reported as 1500 ppm (approximately 2000mg/m3), much higher than the occupational guidelines.
    Methanol
    Methanol (methyl alcohol; wood alcohol) is used extensively as a solvent for lacquers, paints, varnishes, cements, inks, dyes, plastics, and various industrial coatings. Large quantities are used in the production of formaldehyde and other chemical derivatives such as acetic acid, methyl halides and terephthalate, methyl methacrylate, and methylamines. Methanol is also used as a gasoline additive, as a component of lacquer thinners, in antifreeze preparations of the “nonpermanent” type, and in canned heating preparations of jellied alcohol. It is also used in duplicating fluid, in paint removers, and as a cleaning agent. The potential for methanol as a future alternative for gasoline indicates that the use of this chemical will most likely increase rather than decrease. At room temperature, methanol is a colorless liquid with a pungent odor. It is relatively volatile, with a vapor pressure of 96 mmHg and a vapor density of 1.11. It is miscible with water and soluble with other organic solvents. It is found in nature as a fermentation product of wood and as a constituent of some fruits and vegetables.

    Uses

    Methanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce acetic anhydride. It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in medicine and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester.
    Industry
    Applications
    Role/Benefit
    Laboratory
    HPLC, UV/VIS spectroscopy, and LCMS
    Low UV cutoff
    Chemical manufacture
    Production of formaldehyde and its derivates
    Main feedstock
    Production of hydrocarbon chains and even aromatic systems
    Main feedstock
    Production of methyl tert-butyl ether
    Methylation reagent
    Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester
    Main feedstock
    Plastics
    Production of polymers
    Main feedstock
    Farm chemical
    Production of insecticide and acaricide
    Main feedstock
    Pharmaceuticals
    Production of sulfonamides, amycin, etc
    Main feedstock
    Fuel for vehicles
    Pure methanol fuel
    Pure methanol does not produce an opaque cloud of smoke in the event of an accident
    Methanol gasoline
    Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline
    Chemical analysis
    Determination of boron
    Analysis agent
    Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine
    Analysis agent
    Others
    Separation of calcium sulfate and magnesium sulfate
    Separation reagent
    Separation of strontium bromide and barium bromide
    Separation reagent
    Anti-freezing agent
    Effective component

    Methanol poisoning and First Aid Measures

    Pathogenesis
    First, methanol has a cumulative effect and is oxidized in the body into more toxic formaldehyde and formic acid. Methanol and its oxides directly damage the tissues, causing cerebral edema, meningeal hemorrhage, optic nerve and retinal atrophy, pulmonary congestion and edema, and hepatic and renal turbid swelling.
    Second, methanol and its oxides cause blood circulation disorder, coenzyme system obstacles in vivo, resulting in lack of oxygen supply to the brain cortical cells, metabolic disorders, and related neurological and psychiatric symptoms.
    Third, methanol oxidation products combine with the iron in the cytochrome oxidase, which inhibits the intracellular oxidation process thus causing metabolic disorders, acidosis along with organic acid accumulation in the body, and nerve cells impair.

    Treatment Symptoms and treatments:
    Acute pain
    morphine, pethidine
    Convulsions
    phenobarbital, amimystrine, diazepam
    Coma
    caffeine sodium benzoate
    Respiratory failure
    nikethamide, theophylline

    Reactivities of Methanol

    Methanol is the simplest aliphatic alcohol. It contains only one carbon atom. Unlike higher alcohols, it cannot form an olefin through dehydration. However, it can undergo other typical reactions of aliphatic alcohols involving cleavage of a C-H bond or O-H bond and displacement of the -OH group. Table 1 summarizes the reactions of methanol, which are classified in terms of their mechanisms. Examples of the reactions and products are given.

    Homolytic dissociation energies of the C-O and O-H bonds in methanol are relatively high. Catalysts are often used to activate the bonds and to increase the selectivity to desired products.

    Production

       
    If the conditions are strictly controlled, the yield can reach 100% and the purity can reach 99%.

    Toxicity evaluation

    ADI is limited to GMP (FAO/WHO, 2001).
    Toxic, can cause blindness.
    LD50: 5628 mg/kg (rat, oral).
     
    Measurement
    Date
    System
    Route/Organism
    Dose
    Effect
    Skin and Eye Irritation
    December 2016
     
    eye /rabbit
    40 mg
    moderate
    Skin and Eye Irritation
    December 2016
     
    eye /rabbit
    100 mg/24H
    moderate
    Skin and Eye Irritation
    December 2016
     
    skin /rabbit
    20 mg/24H
    moderate
    Mutation Data
    December 2016
    Cytogenetic Analysis
    parenteral/grasshopper
    3000 ppm
     
    Mutation Data
    December 2016
    Cytogenetic Analysis
    oral/mouse
    1 gm/kg
     
    Mutation Data
    December 2016
    Cytogenetic Analysis
    intraperitoneal/mouse
    75 mg/kg
     
    Mutation Data
    December 2016
    DNA Damage
    oral/rat
    10 µmol/kg
     
    Mutation Data
    December 2016
    DNA inhibition
    lymphocyte/human
    300 mmol/L
     
    Mutation Data
    December 2016
    DNA repair
    /Escherichia coli
    20 mg/well
     
    Mutation Data
    December 2016
    morphological transform
    fibroblast/mouse
    0.01 mg/L/21D (-enzymatic activation step)
     
    from The National Institute for Occupational Safety and Health - NIOSH

    Methanol gasoline

    Methanol gasoline refers to the M series mixture fuel made of addition of methanol to the gasoline and formulated using methanol fuel solvent. Among them, M15 (add 15% methanol in gasoline) clean methanol gasoline is used as vehicle fuel, respectively, used in a variety of gasoline engines. It can be applied to substitute the finished gasoline without changing the existing engine structure, and can also be mixed with refined oil. The methanol mixed fuel has excellent thermal efficiency, power, start-up and being economical. It is also characterized by lowering the emissions, saving oil and being safe and convenient. Methanol gasoline types of M35, M15, M20, M50, N85 and M100 with different blend ratios have been developed around the world according to the conditions of different countries. At present, the commercial methanol is mainly M85 (85% methanol + 15% gasoline) and M100 with M100 performance being better than M85 and having greater environmental advantages.

    Description

    Methyl alcohol, also known as methanol or wood alcohol, is a clear, colorless, flammable liquid that is the simplest alcohol.
    World production of methanol is approximately 8.5 billion gallons annually. Methanol is produced industrially, starting with the production of synthesis gas or syngas. Syngas used in the production of methyl alcohol is a mixture of carbon monoxide and hydrogen formed when natural gas reacts with steam or oxygen. Methyl alcohol is then synthesized from carbon monoxide and hydrogen.
    Methyl alcohol is poisonous and is commonly used to denature ethyl alcohol. Methanol poisoning results from ingestion, inhalation of methanol vapors, or absorption through the skin. Methanol is transformed in the body to formaldehyde (H2CO) by the enzyme alcohol dehydrogenase.The formaldehyde is then metabolized to formic acid (HCOOH)by aldehyde dehydrogenase.

    Chemical Properties

    Methanol is a clear, water-white liquid with a mild odor at ambient temperatures.The air odor threshold for methanol has been reported as 100 ppm . Others have reported that 2000 or 5900 ppm methanol is barely detectable .

    Physical properties

    Clear, colorless liquid with a characteristic alcoholic odor. Odor threshold concentrations ranged from 8.5 ppbv (Nagata and Takeuchi, 1990) to 100.0 ppmv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 5.5 mg/m3 (4.2 ppmv) and 69 mg/m3 (53 ppmv), respectively (Hellman and Small, 1974).

    History

    It was first isolated in 1661 by the Irish chemist Robert Boyle (1627–1691) who prepared it by the destructive distillation of boxwood, giving it the name spirit of box, and the name wood alcohol is still used for methyl alcohol. Methyl alcohol is also called pyroxylic spirit; pyroxylic is a general term meaning distilled from wood and indicates that methyl alcohol is formed during pyrolysis of wood. The common name was derived in the mid-1800s. The name methyl denotes the single carbon alkane methane in which a hydrogen atom has been removed to give the methyl radical. The word alcohol is derived from Arabic al kuhul.

    Uses

    Methanol has numerous uses. Its main use is in the production of formaldehyde, whichconsumes approximately 40% of methanol supplies. Methanolis a common organic solvent found in many products including deicers (windshield wiperfl uid), antifreezes, correction fl uid, fuel additives, paints, and other coatings. A number ofindustrial chemicals use methanol in their production. Among these are methyl methacrylateand dimethyl terephthalate. Methanol is used to convert methylacrylamide sulfate to methylmethacrylate and ammonium hydrogen sulfate (NH4HSO4):
    Methanol is used in making the ester dimethyl terephthalate from mixtures ofxylene of toluene. Dimethyl terephthalate is used in the manufacture of polyesters and plastics.
    Methanol is used as a fuel additive. The common gasoline additive HEET is pure methanoland is used as a gas-line antifreeze and water remover. Methanol is used as a fuel in camp stoves and small heating devices. It is used to fuel the small engines used in models (airplanes,boats). In the early history of automobiles,methanol was a common fuel. The availability of cheap gasoline replaced methanol in the1920s, but it is receiving renewed interest as an alternative fuel as the demand and cost of oilincrease and oil supplies become uncertain. Methanol can be produced from coal and biomass.Methanol has a higher octane rating and generally lower pollutant emissions compared togasoline. The relatively low flame temperature means that fewer nitrogen oxides are producedby methanol than by ethanol. One large disadvantage of methanol is that it has a lower energydensity than gasoline. Using equivalent volumes of gasoline and methanol, methanol givesabout half the mileage of gasoline. Another problem with methanol is its low vapor pressure,resulting in starting problems on cold days. This problem can be mitigated by using a blendof 85% methanol and 15% gasoline. This mixture is called M85 and is similar to E85 ethanol(see Ethyl Alcohol).

    Uses

    Methanol is used in the production offormaldehyde, acetic acid, methyl tert-butylether, and many chemical intermediates; asan octane improver (in oxinol); and as apossible alternative to diesel fuel; being anexcellent polar solvent, it is widely used as acommon laboratory chemical and as a methylating reagent.

    Uses

    high purity grade for ICP-MS detection

    Uses

    Methylalcohol, CH30H, also known as methanol or wood alcohol, is a colorless, toxic, flammable liquid with a boiling point of 64.6 °C(147 °F). The principal toxic effect is on the nervous system,particularly the retinae. Methyl alcoholis miscible in all proportions with water,ethyl alcohol, and ether. It burns with a light blue flame producing water and carbon dioxide. This vapor forms an explosive mixture(6.0 to 36.5% by volume) with air. Methyl alcohol is an important inexpensive raw material that is synthetically produced for the organic chemical industry. Nearly half of the methyl alcohol manufactured is used in the production of formaldehyde. Other uses of methyl alcohol are as an antifreeze and fuel for automobiles and as an intermediate in the production of synthetic protein.

    Uses

    Industrial solvent. Raw material for making formaldehyde and methyl esters of organic and inorganic acids. Antifreeze for automotive radiators and air brakes; ingredient of gasoline and diesel oil antifreezes. Octane booster in gasoline. As fuel for picnic stoves and soldering torches. Extractant for animal and vegetable oils. To denature ethanol. Softening agent for pyroxylin plastics. Solvent and solvent adjuvant for polymers. Solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals.

    Definition

    ChEBI: The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.

    Production Methods

    Modern industrial-scale methanol production is exclusively based on synthesis from pressurized mixtures of hydrogen, carbon monoxide, and carbon dioxide gases in the presence of catalysts. Based on production volume, methanol has become one of the largest commodity chemicals produced in the world.

    Reactions

    Methyl alcohol is a versatile material, reacting (1) with sodium metal, forming sodium methylate, sodium methoxide CH3ONa plus hydrogen gas, (2) with phosphorus chloride, bromide, iodide, forming methyl chloride, bromide, iodide, respectively, (3) with H2SO4 concentrated, forming dimethyl ether (CH3)2O, (4) with organic acids, warmed in the presence of H2SO4, forming esters, e.g., methyl acetate CH3COOCH3, [CAS: 79-20-9], methyl salicylate C6H4(OH)·COOCH3, possessing characteristic odors, (5) with magnesium methyl iodide in anhydrous ether (Grignard’s solution), forming methane as in the case of primary alcohols, (6) with calcium chloride, forming a solid addition compound 4CH3OH·CaCl2, which is decomposed by H2O, (7) with oxygen, in the presence of heated smooth copper or silver forming formaldehyde. The density of pure methyl alcohol is 0.792 at 20 °C compared with H2O at 4 °C (the corresponding figure for ethyl alcohol is 0.789), and the percentage of methyl alcohol present in a methyl alcohol-water solution may be determined from the density of the sample.

    World Health Organization (WHO)

    Methanol has been subjected to abuse by consumption as a substitute for ethanol. Its toxic metabolites cause irreversible blindness and severe metabolic acidosis, and are ultimately fatal. Methanol continues to be used as an industrial solvent.

    General Description

    A colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Completely mixes with water. The vapors are slightly heavier than air and may travel some distance to a source of ignition and flash back. Any accumulation of vapors in confined spaces, such as buildings or sewers, may explode if ignited. Used to make chemicals, to remove water from automotive and aviation fuels, as a solvent for paints and plastics, and as an ingredient in a wide variety of products.

    Reactivity Profile

    Methanol reacts violently with acetyl bromide [Merck 11th ed. 1989]. Mixtures with concentrated sulfuric acid and concentrated hydrogen peroxide can cause explosions. Reacts with hypochlorous acid either in water solution or mixed water/carbon tetrachloride solution to give methyl hypochlorite, which decomposes in the cold and may explode on exposure to sunlight or heat. Gives the same product with chlorine. Can react explosively with isocyanates under basic conditions. The presence of an inert solvent mitigates this reaction [Wischmeyer 1969]. A violent exothermic reaction occurred between methyl alcohol and bromine in a mixing cylinder [MCA Case History 1863. 1972]. A flask of anhydrous lead perchlorate dissolved in Methanol exploded when Methanol was disturbed [J. Am. Chem. Soc. 52:2391. 1930]. P4O6 reacts violently with Methanol. (Thorpe, T. E. et al., J. Chem. Soc., 1890, 57, 569-573). Ethanol or Methanol can ignite on contact with a platinum-black catalyst. (Urben 1794).

    Hazard

    Flammable, dangerous fire risk. Explosive limits in air 6–36.5% by volume. Toxic by ingestion (causes blindness). Headache, eye damage, dizziness, and nausea.

    Health Hazard

    Ingestion of adulterated alcoholic beveragescontaining methanol has resulted in innumerable loss of human lives throughout theworld. It is highly toxic, causing acidosis andblindness. The symptoms of poisoning arenausea, abdominal pain, headache, blurredvision, shortness of breath, and dizziness.In the body, methanol oxidizes to formaldehyde and formic acid — the latter could bedetected in the urine, the pH of which is lowered (when poisoning is severe).
    The toxicity of methanol is attributed tothe metabolic products above. Ingestion inlarge amounts affects the brain, lungs, gastrointestinal tract, eyes, and respiratory system and can cause coma, blindness, anddeath. The lethal dose is reported to be60–250 mL. The poisoning effect is prolonged and the recovery is slow, often causing permanent loss of sight.
    Other exposure routes are inhalation andskin absorption. Exposure to methanol vaporto at 2000 ppm at regular intervals over aperiod of 4 weeks caused upper respiratorytract irritation and mucoid nasal discharge inrats. Such discharge was found to be a doserelated effect.
    Inhalation in humans may produce headache, drowsiness, and eye irritation. Prolonged skin contact may cause dermatitis andscaling. Eye contact can cause burns anddamage vision..

    Health Hazard

    The acute toxicity of methanol by ingestion, inhalation, and skin contact is low. Ingestion of methanol or inhalation of high concentrations can produce headache, drowsiness, blurred vision, nausea, vomiting, blindness, and death. In humans, 60 to 250 mL is reported to be a lethal dose. Prolonged or repeated skin contact can cause irritation and inflammation; methanol can be absorbed through the skin in toxic amounts. Contact of methanol with the eyes can cause irritation and burns. Methanol is not considered to have adequate warning properties.
    Methanol has not been found to be carcinogenic in humans. Information available is insufficient to characterize the reproductive hazard presented by methanol. In animal tests, the compound produced developmental effects only at levels that were maternally toxic; hence, it is not considered to be a highly significant hazard to the fetus. Tests in bacterial or mammalian cell cultures demonstrate no mutagenic activity

    Fire Hazard

    Behavior in Fire: Containers may explode.

    Flammability and Explosibility

    Methanol is a flammable liquid (NFPA rating = 3) that burns with an invisible flame in daylight; its vapor can travel a considerable distance to an ignition source and "flash back." Methanol-water mixtures will burn unless very dilute. Carbon dioxide or dry chemical extinguishers should be used for methanol fires.

    Chemical Reactivity

    Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization:Not pertinent; Inhibitor of Polymerization: Not pertinent.

    Safety Profile

    A human poison by ingestion. Poison experimentally by skin contact. Moderately toxic experimentally by intravenous and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects: changes in circulation, cough, dyspnea, headache, lachrymation, nausea or vomiting, optic nerve neuropathy, respiratory effects, visual field changes. An experimental teratogen. Experimental reproductive effects. An eye and skin irritant. Human mutation data reported. A narcotic. Its main toxic effect is exerted upon the nervous system, particularly the optic nerves and possibly the retinae. The condtion can progress to permanent blindness. Once absorbed, methanol is only very slowly eliminated. Coma resulting from massive exposures may last as long as 2-4 days. In the body, the products formed by its oxidation are formaldehyde and formic acid, both of which are toxic. Because of the slow elimination, methanol should be regarded as a cumulative poison. Though single exposures to fumes may cause no harmful effect, daily exposure may result in the accumulation of sufficient methanol in the body to cause illness. Death from ingestion of less than 30 mL has been reported. A common air contaminant. Flammable liquid. Dangerous fire hazard when exposed to heat, flame, or oxidlzers. Explosive in the form of vapor when exposed to heat or flame. Explosive reaction with chloroform + sodium methoxide, diethyl zinc. Violent reaction with alkyl aluminum salts, acetyl bromide, chloroform + sodlum hydroxide, CrO3, cyanuric chloride, (I + ethanol + HgO), Pb(ClO4)2, HClO4, P2O3, (KOH + CHCb), nitric acid. Incompatible with berylhum dihydride, metals (e.g., potassium, magnesium), oxidants (e.g., barium perchlorate, bromine, sodium hypochlorite, chlorine, hydrogen peroxide), potassium tert-butoxide, carbon tetrachloride + metals (e.g., aluminum, magnesium, zinc), dlchloromethane. Dangerous; can react vigorously with oxidizing materials. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.

    Source

    Methanol occurs naturally in small-flowered oregano (5 to 45 ppm) (Baser et al., 1991), Guveyoto shoots (700 ppb) (Baser et al., 1992), orange juice (0.8 to 80 ppm), onion bulbs, pineapples, black currant, spearmint, apples, jimsonweed leaves, soybean plants, wild parsnip, blackwood, soursop, cauliflower, caraway, petitgrain, bay leaves, tomatoes, parsley leaves, and geraniums (Duke, 1992).
    Methanol may enter the environment from methanol spills because it is used in formaldehyde solutions to prevent polymerization (Worthing and Hance, 1991).

    Environmental Fate

    Biological. In a 5-d experiment, [14C]methanol applied to soil water suspensions under aerobic and anaerobic conditions gave 14CO2 yields of 53.4 and 46.3%, respectively (Scheunert et al., 1987). Heukelekian and Rand (1955) reported a 5-d BOD value of 0.85 g/g which is 56.7% of the ThOD value of 1.50 g/g. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM methanol) and ThOD were 0.93 and 62.0%, respectively (Vaishnav et al., 1987).
    Photolytic. Photooxidation of methanol in an oxygen-rich atmosphere (20%) in the presence of chlorine atoms yielded formaldehyde and hydroxyperoxyl radicals. The reaction is initiated via hydrogen abstraction by OH radicals or chlorine atoms yielding a hydroxymethyl radical. Chlorine, formaldehyde, carbon monoxide, hydrogen peroxide, and formic acid were detected (Whitbeck, 1983). Reported rate constants for the reaction of methanol and OH radicals in the atmosphere: 5.7 x 10-11 cm3/mol·sec at 300 K (Hendry and Kenley, 1979), 5.7 x 10-8 L/mol·sec (second-order) at 292 K (Campbell et al., 1976), 1.00 x 10-12 cm3/molecule·sec at 292 K (Meier et al., 1985), 7.6 x 10-13 cm3/molecule·sec at 298 K (Ravishankara and Davis, 1978), 6.61 x 10-13 cm3/molecule·sec at room temperature (Wallington et al., 1988a). Based on an atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported half-life of methanol is 8.6 d (Grosjean, 1997).
    Chemical/Physical. In a smog chamber, methanol reacted with nitrogen dioxide to give methyl nitrite and nitric acid (Takagi et al., 1986). The formation of these products was facilitated when this experiment was accompanied by UV light (Akimoto and Takagi, 1986). Methanol will not hydrolyze because it does not have a hydrolyzable functional group (Kollig, 1993).
    At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 964 mg/L. The adsorbability of the carbon used was 7 mg/g carbon (Guisti et al., 1974).
    Hydroxyl radicals react with methanol in aqueous solution at a reaction rate of 1.60 x 10-12 cm3/molecule?sec (Wallington et al., 1988).
    Complete combustion in air produces carbon dioxide and water. The stoichiometric equation for this oxidation reaction is:
    2CH4O + 3O2 → 2CO2 + 4H2O

    storage

    Methanol should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

    Shipping

    UN1230 Methanol, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous material. (International)

    Purification Methods

    Almost all methanol is now obtained synthetically. Likely impurities are water, acetone, formaldehyde, ethanol, methyl formate and traces of dimethyl ether, methylal, methyl acetate, acetaldehyde, carbon dioxide and ammonia. Most of the water (down to about 0.01%) can be removed by fractional distillation. Drying with CaO is unnecessary and wasteful. Anhydrous methanol can be obtained from "absolute" material by passage through Linde type 4A molecular sieves, or by drying with CaH2, CaSO4, or with just a little more sodium than required to react with the water present, in all cases the methanol is then distilled. Two treatments with sodium reduces the water content to about 5 x 10-5%. [Friedman et al. J Am Chem Soc 83 4050 1961.] Lund and Bjerrum [Chem Ber 64 210 1931] warmed clean dry magnesium turnings (5g) and iodine (0.5g) with 50-75mL of "absolute" methanol in a flask until the iodine disappeared and all the magnesium was converted to the methoxide. Up to 1L of methanol was added and, after refluxing for 2-3hours, it was distilled off, excluding moisture from the system. Redistillation from tribromobenzoic acid removes basic impurities and traces of magnesium oxides, and leaves conductivity-quality material. The method of Hartley and Raikes [J Chem Soc 127 524 1925] gives a slightly better product. This consists of an initial fractional distillation, followed by distillation from aluminium methoxide, and then ammonia and other volatile impurities are removed by refluxing for 6hours with freshly dehydrated CuSO4 (2g/L) while dry air is passed through: the methanol is finally distilled. (The aluminium methoxide is prepared by warming with aluminium amalgam (3g/L) until all the aluminium has reacted. The amalgam is obtained by warming pieces of sheet aluminium with a solution of HgCl2 in dry methanol.) This treatment also removes aldehydes. If acetone is present in the methanol, it is usually removed prior to drying. Bates, Mullaly and Hartley [J Chem Soc 401 1923] dissolved 25g of iodine in 1L of methanol and then poured the solution, with constant stirring, into 500mL of M NaOH. Addition of 150mL of water precipitated iodoform. The solution was allowed to stand overnight, filtered, then boiled under reflux until the odour of iodoform disappeared, and fractionally distilled. (This treatment also removes formaldehyde.) Morton and Mark [Ind Eng Chem (Anal Edn) 6 151 1934] refluxed methanol (1L) with furfural (50mL) and 10% NaOH solution (120mL) for 6-12hours, the refluxing resin carries down with it the acetone and other carbonyl-containing impurities. The alcohol was then fractionally distilled. Evers and Knox [J Am Chem Soc 73 1739 1951], after refluxing 4.5L of methanol for 24hours with 50g of magnesium, distilled off 4L of it, which they then refluxed with AgNO3 for 24hours in the absence of moisture or CO2. The methanol was again distilled, shaken for 24hours with activated alumina before being filtered through a glass sinter and distilled under nitrogen in an all-glass still. Material suitable for conductivity work was obtained. Variations of the above methods have also been used. For example, a sodium hydroxide solution containing iodine has been added to methanol and, after standing for 1day, the solution has been poured slowly into about a quarter of its volume of 10% AgNO3, shaken for several hours, then distilled. Sulfanilic acid has been used instead of tribromobenzoic acid in Lund and Bjerrum's method. A solution of 15g of magnesium in 500mL of methanol has been heated under reflux, under nitrogen, with hydroquinone (30g), before degassing and distilling the methanol, which was subsequently stored with magnesium (2g) and hydroquinone (4g per 100mL). Refluxing for about 12hours removes the bulk of the formaldehyde from methanol: further purification has been obtained by subsequent distillation, refluxing for 12hours with dinitrophenylhydrazine (5g) and H2SO4 (2g/L), and again fractionally distilling. [Beilstein 1 IV 1227.]

    Toxicity evaluation

    The toxic properties of methanol are the result of accumulation of the formate intermediate in the blood and tissues of exposed individuals. Formate accumulation produces metabolic acidosis leading to the characteristic ocular toxicity (blindness) observed in human methanol poisonings.
    Humans and primates appear particularly sensitive to methanol toxicity when compared to rats. This is attributed to the slower rate of conversion in humans of the formate metabolite via tetrahydrofolate. This step in methanol metabolism occurs in rats at a rate ~2.5 times that observed in humans.
    Formate appears to directly affect the retina and optic nerve by acting as a mitochondrial toxin. It is believed that formate acts as a metabolic poison by inhibiting cytochrome oxidase activity. The cells of the optic nerve have low reserves of cytochrome oxidase and thus may be particularly sensitive to formate-induced metabolic inhibition.

    Incompatibilities

    Methanol reacts violently with strong oxidizers, causing a fire and explosion hazard.

    Waste Disposal

    Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration

    Methanol Preparation Products And Raw materials

    Raw materials

    Preparation Products


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