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    Silica, fumed

    Silica, fumed
    Silica, fumed structure
    CAS No.
    Chemical Name:
    Silica, fumed
    Molecular Formula:
    Formula Weight:
    MOL File:

    Silica, fumed Properties

    Melting point:
    2.3 lb/cu.ft at 25 °C (bulk density)(lit.)
    refractive index 
    n20/D 1.46(lit.)
    Practically insoluble in organic solvents, water, and acids, except hydrofluoric acid; soluble in hot solutions of alkali hydroxide. Forms a colloidal dispersion with water. For Aerosil, solubility in water is 150 mg/L at 258℃ (pH 7).
    Specific Gravity
    Hydrolytic Sensitivity
    5: forms reversible hydrate
    CAS DataBase Reference
    112945-52-5(CAS DataBase Reference)
    EWG's Food Scores
    NCI Dictionary of Cancer Terms
    EPA Substance Registry System
    Silica, amorphous, fumed, cryst.-free (112945-52-5)
    • Risk and Safety Statements
    Safety Statements  24/25
    WGK Germany  2
    RTECS  VV7310000
    TSCA  Yes
    HS Code  28112290

    Silica, fumed price More Price(43)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich SX0076 Sand Sea 112945-52-5 500 g $19.52 2021-03-22 Buy
    Sigma-Aldrich 274739 Sand 50-70?mesh particle size 112945-52-5 500 g $39.4 2021-03-22 Buy
    Sigma-Aldrich SX0075 Sand Standard, washed and dried 112945-52-5 500 g $47.91 2021-03-22 Buy
    Sigma-Aldrich 13767 Silica gel orange with moisture indicator free of heavy metals 112945-52-5 500 g $48.7 2021-03-22 Buy
    Sigma-Aldrich 274739 Sand 50-70?mesh particle size 112945-52-5 1 kg $49 2021-03-22 Buy

    Silica, fumed Chemical Properties,Uses,Production

    Chemical Properties

    Amorphous silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder

    Chemical Properties

    Colloidal silicon dioxide is a submicroscopic fumed silica with a particle size of about 15 nm. It is a light, loose, bluish-white-colored, odorless, tasteless, amorphous powder.

    Production Methods

    Colloidal silicon dioxide is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 18008℃ using a hydrogen–oxygen flame. Rapid cooling from the molten state during manufacture causes the product to remain amorphous.

    Pharmaceutical Applications

    Colloidal silicon dioxide is widely used in pharmaceuticals, cosmetics, and food products. Its small particle size and large specific surface area give it desirable flow characteristics that are exploited to improve the flow properties of dry powders in a number of processes such as tableting and capsule filling.
    Colloidal silicon dioxide is also used to stabilize emulsions and as a thixotropic thickening and suspending agent in gels and semisolid preparations. With other ingredients of similar refractive index, transparent gels may be formed. The degree of viscosity increase depends on the polarity of the liquid (polar liquids generally require a greater concentration of colloidal silicon dioxide than nonpolar liquids). Viscosity is largely independent of temperature. However, changes to the pH of a system may affect the viscosity1.
    In aerosols, other than those for inhalation, colloidal silicon dioxide is used to promote particulate suspension, eliminate hard settling, and minimize the clogging of spray nozzles. Colloidal silicon dioxide is also used as a tablet disintegrant and as an adsorbent dispersing agent for liquids in powders. Colloidal silicon dioxide is frequently added to suppository formulations containing lipophilic excipients to increase viscosity, prevent sedimentation during molding, and decrease the release rate. Colloidal silicon dioxide is also used as an adsorbent during the preparation of wax microspheres; as a thickening agent for topical preparations; and has been used to aid the freeze-drying of nanocapsules and nanosphere suspensions.

    Safety Profile

    Poison by intraperitoneal, intravenous, and intratracheal routes. Moderately toxic by ingestion. An inhalation hazard. Much less toxic than crystalhe forms. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Does not cause silicosis. See also other silica entries


    Colloidal silicon dioxide is widely used in oral and topical pharmaceutical products and is generally regarded as an essentially nontoxic and nonirritant excipient. However, intraperitoneal and subcutaneous injection may produce local tissue reactions and/or granulomas. Colloidal silicon dioxide should therefore not be administered parenterally.
    LD50 (rat, IV): 0.015 g/kg
    LD50 (rat, oral): 3.16 g/kg

    Potential Exposure

    Amorphous fumed silica is used as a mineral, natural or synthetic fiber. A potential danger to those involved in the production and handling of fumed silica for paint pigments or catalysts. Diatomaceous earth is used in clarifying liquids, in manufacture of fire brick and heat insulators; used as a filtering agent; as a filler in construction materials; pesticides, paints, and varnishes. A potential danger to those involved in mining of diatomaceous earth or fabrication of products there from.


    Colloidal silicon dioxide is hygroscopic but adsorbs large quantities of water without liquefying. When used in aqueous systems at a pH 0–7.5, colloidal silicon dioxide is effective in increasing the viscosity of a system. However, at a pH greater than 7.5 the viscosityincreasing properties of colloidal silicon dioxide are reduced; and at a pH greater than 10.7 this ability is lost entirely since the silicon dioxide dissolves to form silicates. Colloidal silicon dioxide powder should be stored in a well-closed container.

    Purification Methods

    Purification of silica for high technology applications uses isopiestic vapour distillation from concentrated volatile acids and is absorbed in high purity water. The impurities remain behind. Preliminary cleaning to remove surface contaminants uses dip etching in HF or a mixture of HCl, H2O2 and deionised water [Phelan & Powell Analyst 109 1299 1984].


    Silica, amorphous is a noncombustible solid. Generally unreactive chemically. Incompatible with fluorine, oxygen difluoride, chlorine trifluoride. Soluble in molten alkalis and reacts with most metallic oxides at high temperature.


    Incompatible with diethylstilbestrol preparations.

    Waste Disposal

    Sanitary landfill.

    Regulatory Status

    GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions, and tablets; transdermal, rectal, and vaginal preparations). Also approved by the FDA as a food additive and for food contact. Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

    Silica, fumed Preparation Products And Raw materials

    Raw materials

    Preparation Products

    Silica, fumed Suppliers

    Global( 272)Suppliers
    Supplier Tel Fax Email Country ProdList Advantage
    Hangzhou Bayee Chemical Co., Ltd.
    0086-571-85775919 rachelhoo@bayeechem.com China 105 55
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693 info@tianfuchem.com CHINA 22607 55
    Hefei TNJ Chemical Industry Co.,Ltd.
    86-0551-65418684 18949823763
    86-0551-65418684 info@tnjchem.com China 3001 55
    hdzhl biotechnology co., ltd
    sales@luchibiology.com CHINA 1275 58
    Xiamen AmoyChem Co., Ltd
    +86 592-605 1114
    sales@amoychem.com CHINA 6369 58
    Hubei xin bonus chemical co. LTD
    027-59338440 linda@hubeijusheng.com CHINA 23035 58
    Shandong chuangyingchemical Co., Ltd.
    sale@chuangyingchem.com CHINA 5917 58
    Shanghai Longyu Biotechnology Co., Ltd.
    info@longyupharma.com CHINA 2462 58
    career henan chemical co
    13203830695 0086-371-86658258
    0086-371-86658258 factory@coreychem.com CHINA 29865 58
    Zhengzhou Alfa Chemical Co.,Ltd
    +86 13343822234
    sales5@alfachem.cn;sales9@alfachem.cn;sale1@alfachem.cn;sales7@alfachem.cn CHINA 15027 58

    View Lastest Price from Silica, fumed manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2020-11-26 Silicon Oxide
    US $5.50 / KG 100KG 99% 100 Hebei Henghe Import and Export Trading Co. LTD
    2019-12-23 Silica, fumed
    US $1.00 / KG 1KG 99 100kg Career Henan Chemical Co

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