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    Sodium gluconate

    Uses Preparation Use Restriction Content Analysis
    Sodium gluconate
    Sodium gluconate structure
    CAS No.
    Chemical Name:
    Sodium gluconate
    glonsen;pasexon100t;BVD Addicrete;Sunmorl N 60S;Disparlight DV;Developer,partB;Natriumgluconat;gluconatodisodio;SODIUM GLUCONATE;SOIDUMD-GLUCONATE
    Molecular Formula:
    Formula Weight:
    MOL File:

    Sodium gluconate Properties

    Melting point:
    170-175 °C
    [α]D20 +11~+13° (c=10, H2O)
    storage temp. 
    Store below +30°C.
    H2O: 0.1 g/mL, clear
    Crystalline Powder
    White to light beige
    7.0-8.0 (100g/l, H2O, 20℃)
    Water Solubility 
    Very soluble in water; sparingly soluble in alcohol; insoluble in ether.
    Stable. Incompatible with strong oxidizing agents.
    Substances Added to Food (formerly EAFUS)
    SCOGS (Select Committee on GRAS Substances)
    Sodium gluconate
    CAS DataBase Reference
    527-07-1(CAS DataBase Reference)
    FDA 21 CFR
    182.6757; 582.6757
    EWG's Food Scores
    EPA Substance Registry System
    Sodium gluconate (527-07-1)
    • Risk and Safety Statements
    Safety Statements  24/25
    WGK Germany  1
    RTECS  LZ5235000
    Autoignition Temperature >200 °C
    TSCA  Yes
    HS Code  29181600
    Toxicity LD50 orally in Rabbit: > 2000 mg/kg

    Sodium gluconate price More Price(46)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 8.22058 Gluconic acid sodium salt for synthesis 527-07-1 100 g $19.15 2021-12-16 Buy
    Sigma-Aldrich 8.22058 Gluconic acid sodium salt for synthesis 527-07-1 1 kg $27.1 2021-12-16 Buy
    Sigma-Aldrich G9005 D-Gluconic acid sodium salt ≥99% 527-07-1 1kg $47.9 2021-12-16 Buy
    Sigma-Aldrich 8.22058 Gluconic acid sodium salt for synthesis 527-07-1 2.5 kg $49.58 2021-12-16 Buy
    Sigma-Aldrich 64188 D-Gluconic acid sodium salt certified reference material, TraceCERT 527-07-1 100mg $100 2021-12-16 Buy

    Sodium gluconate Chemical Properties,Uses,Production



    The calcium gluconate is added into the reaction kettle. Add sulfuric acid aqueous solution while stirring. After mixing for one hour, let it stand for a while and then get it filtered. The filter residue is CaSO4 and gets it removed. The filtrate is added into the neutralization kettle, and a proper amount of Na2CO3 aqueous solution is added to neutralize it. Finally get it through concentration, filtration and drying. Check the finished products with proper packaging.

    Use Restriction

    Within the limit of GMP(FDA,§182.6757,2000).

    Content Analysis

    Weigh the sample of about 750mg. Put it into a dry conical flask of 200ml. Add glacial acetic acid of 75 ml to it. Heat the mixture on the heating plate and after it dissolves, get it cooled. Add several drops of quinaldine red solution (TS-203), use glacial acetic acid solution of 0.1mol/L perchloric acid to titrate the mixture until it gets colorless through microburet of 10ml. Perchloric acid per ml0.1mol/L is equivalent to sodium gluconate (C6H11NaO7) 21.81mg.

    Chemical Properties

    white or off-white granular powder


    Sodium gluconate,JUNGBUNZLAUER INC.


    electrolyte replenisher


    Sodium gluconate has been used as a component of recording buffer used in two-electrode voltage-clamp (TEVC) recording in Xenopus laevis oocytes. It has also been used as a control for sodium.


    ChEBI: An organic sodium salt having D-gluconate as the counterion.

    Manufacturing Process

    D-Gluconic acid was prepared by fermentation of glucose with Aspergillus niger CCM 8004 at 30°C. The fermentation medium contained 150 g/dm-3 glucose, 0.59 g/dm-3 ammonium sulfate, 0.25 g/dm-3 potassium chloride, 0.25 g/dm-3 potassium dihydrophosphate, 0.25 g/dm-3 MgSO4·7H2O, 1.0 g/dm-3 Ca(NO3)2·4H2O, and 1.5 g/dm-3 of a 50% corn-steep liquor. The pH of the culture was maintained at the value of 6.5 during the growth phase and 5.5 (maximum glucose oxidase activity) during the production phase by addition of 11.7 M sodium hydroxide solution. Gluconic acid concentration was determined by HPLC analysis. By neutralization of D-gluconic acid with sodium hydroxide was obtained monosodium D-gluconate.

    Therapeutic Function

    Electrolyte replenisher

    Biochem/physiol Actions

    Ingestion of sodium gluconate is known to stimulate the production of intestinal butyrate. It is widely used in food, pharmaceutical paper and textile industry. It acts as a chelating agent. Sodium gluconate serves as a detergent in bottle washing formulation.

    Safety Profile

    Low toxicity by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes

    Purification Methods

    Crystallise it from a small volume of H2O (solubility is 59g/100mL at 25o), or dissolve it in H2O and add EtOH since it is sparingly soluble in EtOH. It is insoluble in Et2O. It forms a Cu complex in alkaline solution and a complex with Fe in neutral solution. [cf p 639, Sawyer & Bagger J Am Chem Soc 81 5302 1959, Beilstein 3 I 188.]

    Sodium gluconate Preparation Products And Raw materials

    Raw materials

    Preparation Products

    Sodium gluconate Suppliers

    Global( 516)Suppliers
    Supplier Tel Fax Email Country ProdList Advantage
    Capot Chemical Co.,Ltd.
    +86(0)13336195806 +86-571-85586718
    +86-571-85864795 sales@capotchem.com China 20012 60
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693 info@tianfuchem.com China 22607 55
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    Hubei Jusheng Technology Co.,Ltd.
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    Hebei Guanlang Biotechnology Co., Ltd.
    alice@crovellbio.com China 5943 58
    Cangzhou Wanyou New Material Technology Co.,Ltd
    sales@czwytech.com CHINA 914 58

    View Lastest Price from Sodium gluconate manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2022-01-21 Sodium gluconate
    US $8.00 / Kg/Drum 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
    2022-01-20 Sodium gluconate
    US $10.00-10.00 / KG 1KG 99% 500tons/month Shanxi Naipu Import and Export Co.,Ltd
    2022-01-06 Sodium gluconate
    US $80.00 / KG 1KG Above96% Weekly supply of 1000KG Wuhan Dujiang Industrial Co., Ltd.

    Sodium gluconate Spectrum

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