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    Dextran Sulfate Sodium Salt

    Description Uses Toxicity
    Dextran Sulfate Sodium Salt
    Dextran Sulfate Sodium Salt structure
    CAS No.
    9011-18-1
    Chemical Name:
    Dextran Sulfate Sodium Salt
    Synonyms
    asuro;dexnon;ds-m-1;dexulate;Ccris 196;dextrarine;Dextran Mw;DEXSATEMPO(TM);DEXTRALIP(R) 50;DEXTRAN SULFATE
    CBNumber:
    CB9339022
    Molecular Formula:
    (C6H7Na3O14S3)n
    Formula Weight:
    0
    MOL File:
    Mol file

    Dextran Sulfate Sodium Salt Properties

    storage temp. 
    room temp
    solubility 
    H2O: 100 mg/mL
    form 
    powder
    color 
    White to off-white
    PH
    pH(50g/l, 25℃)4.5~8.0
    Water Solubility 
    Soluble in water.
    Merck 
    2951
    EWG's Food Scores
    1
    EPA Substance Registry System
    Dextran, hydrogen sulfate, sodium salt (9011-18-1)
    SAFETY
    • Risk and Safety Statements
    Hazard Codes  Xi,Xn
    Risk Statements  20/21/22-36/37/38
    Safety Statements  26-36-37/39-24/25
    WGK Germany  2
    RTECS  HH9290000
    3-10
    TSCA  Yes
    HS Code  39139000

    Dextran Sulfate Sodium Salt price More Price(76)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 5 g $49.3 2021-03-22 Buy
    Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade 9011-18-1 10gm-m $69.3 2020-08-18 Buy
    Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem Used to accelerate hybridization of DNA probes to immobilized nucleic acids. 9011-18-1 10 g $74.5 2021-03-22 Buy
    Sigma-Aldrich 3710-OP OmniPur Dextran Sulfate Sodium - CAS 9011-18-1 - Calbiochem 9011-18-1 50 g $132.27 2021-03-22 Buy
    Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem Used to accelerate hybridization of DNA probes to immobilized nucleic acids. 9011-18-1 50 g $228.47 2021-03-22 Buy

    Dextran Sulfate Sodium Salt Chemical Properties,Uses,Production

    Description

    Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
    With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
    Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
    Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.

    Uses

    1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
    2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
    3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

    Toxicity

    The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
    More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

    Chemical Properties

    White to off-white powder

    Uses

    Clinical reagent (HDL cholesterol determination).

    Uses

    Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.

    Dextran Sulfate Sodium Salt Preparation Products And Raw materials

    Raw materials

    Preparation Products


    Dextran Sulfate Sodium Salt Suppliers

    Global( 258)Suppliers
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    Herbon International Holdings Company Limited
    (+86) 0762 3499803
    (+86) 0762 3499555 info@herbon-international.com CHINA 3 55
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com CHINA 22607 55
    Hangzhou FandaChem Co.,Ltd.
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    +86-571-56059825 fandachem@gmail.com CHINA 8882 55
    Shanxi Naipu Import and Export Co.,Ltd
    +8613734021967
    kaia@neputrading.com CHINA 1011 58
    Shanghai Zheyan Biotech Co., Ltd.
    18017610038
    zheyansh@163.com CHINA 3623 58
    career henan chemical co
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    sales@coreychem.com CHINA 29961 58
    SHANDONG ZHI SHANG CHEMICAL CO.LTD
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    +86 0531-67809011 sales@sdzschem.com CHINA 2858 58
    Jinan Carbotang Biotech Co.,Ltd.
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    Hebei Guanlang Biotechnology Co., Ltd.
    +8619930503282
    sales3@crovellbio.com China 5392 58
    Hubei xin bonus chemical co. LTD
    86-13657291602
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    View Lastest Price from Dextran Sulfate Sodium Salt manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2021-10-20 Dextran Sulfate Sodium Salt
    9011-18-1
    US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
    2021-09-07 Dextran Sulfate Sodium Salt
    9011-18-1
    US $10.00 / Kg/Drum 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
    2021-08-14 Dextran sulfate sodium
    9011-18-1
    US $10.00 / KG 1KG 99 100 mt Shijiazhuang tongyang Import and Export Co., LTD

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