• ChemicalBook
    Chinese Japanese Germany Korea

    Corosolic acid

    Clinical application and efficacy Physical and Chemical Properties Lagerstroemia speciosa extract Plant sources Reference quality standards
    Corosolic acid
    Corosolic acid structure
    CAS No.
    4547-24-4
    Chemical Name:
    Corosolic acid
    Synonyms
    Glucosol;Corosolic;Corsolicacid;Corosolicaci;COROSOLIC ACID;Colosolic acid;Barnabas extract;Corosolic acid, BR;HYDROXYURSOLIC ACID;Corosolic acid 1%-20%
    CBNumber:
    CB9466988
    Molecular Formula:
    C30H48O4
    Formula Weight:
    472.7
    MOL File:
    4547-24-4.mol

    Corosolic acid Properties

    Melting point:
    243~245℃
    Boiling point:
    573.3±50.0 °C(Predicted)
    Density 
    1.14±0.1 g/cm3(Predicted)
    storage temp. 
    2-8°C
    solubility 
    methanol: soluble1mg/mL, clear, colorless
    form 
    neat
    pka
    4.67±0.70(Predicted)
    CAS DataBase Reference
    4547-24-4(CAS DataBase Reference)
    FDA UNII
    AMX2I57A98
    SAFETY
    • Risk and Safety Statements
    WGK Germany  3
    HS Code  2918195000

    Corosolic acid price More Price(8)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 89067 Corosolic acid analytical standard 4547-24-4 10mg $352 2021-03-22 Buy
    Sigma-Aldrich 1148737 Corosolic acid United States Pharmacopeia (USP) Reference Standard 4547-24-4 50mg $857 2021-03-22 Buy
    Cayman Chemical 27887 Corosolic Acid 4547-24-4 50mg $525 2021-03-22 Buy
    Cayman Chemical 27887 Corosolic Acid 4547-24-4 5mg $75 2021-03-22 Buy
    Sigma-Aldrich G0549 Corosolic acid from Lagerstroemia speciosa ≥98% (HPLC) 4547-24-4 10mg $289 2021-03-22 Buy

    Corosolic acid Chemical Properties,Uses,Production

    Clinical application and efficacy

    Corosolic acid can be used as the novel plant-derived drug for prevention and treatment of obesity and type II diabetes drugs as well as the pharmaceutical raw materials of functional natural health food. It has currently become a hot product in the market. Currently the natural product has entered into market as a nutritional supplement in the United States and has been also subject to the Phase III clinical trials for the treatment of diabetes and will soon be approved by the FDA in the near future. Compared its efficacy in treating diabetes with that of the injections of insulin, it has various advantages such as significant oral administration effect, small toxic side effects, and being convenient for administration. Its efficacy is quite similar with injection of insulin.
    The content of corosolic acid content in plants is generally low, even in the Lagerstroemia speciosa which has relative high content of Corosolic aicd. In the hot-wvater extracted concentrated extract of Lagerstroemia speciosa, the corosolic acid content is only about 0.01%. Even in the alocohol extract of Barnabas leaf, corosolic acid content is only about 1%. With years of research, Microherb has adopted advanced chromatographic separation technology for successfully isolation high purity (98%) corosolic acid, which can be further used for pharmacodynamic studies, clinical studies as well as toxicological experiment for prevention oadn treatment of obesity and type II diabetes.
    The major efficacy of corosolic acid as follows:
    1. it can regulate the content of insulin and blood sugar with significant trend of weight loss in a slow process without the necessary for dieting. It therefore can be used for weight loss.
    2. this product has a significant hypoglycemic effect.
    3. it has a significant inhibitory effect on inflammation with the anti-inflammatory effect being stronger than commercially available anti-inflammatory drug, indomethacin.
    4. it has inhibitory effect on the proliferation of various kinds of tumors, and thus have wide prospects of applications in this field.

    Physical and Chemical Properties

    It is amorphous white powder (methanol), also known as plant insulin, 2α-hydroxy ursolic acid, and Barabbas extract or Lagerstroemia speciosa extract. It belongs to α-amyrin type or alkyl-type pentacyclic triterpenoids, and is soluble in petroleum ether, benzene, chloroform, pyridine and some other organic solvents, but insoluble in water; it is also soluble in hot ethanol, methanol. Under anhydrous conditions, when it is reacted with a strong acid (sulfuric acid, phosphoric acid, perchloric acid), the acid (TCA) or Lewis's acid (zinc chloride, aluminum chloride, antimony trichloride), there will be colorimetric reaction or fluorescence.
    the structural formula of corosolic acid
    Figure 1 the structural formula of corosolic acid
    The above information is edited by the chemicalbook of Dai Xiongfeng.

    Lagerstroemia speciosa extract

    Corosolic acid is a kind of triterpenoids which is naturally presented in Lagerstroemia. Its basic skeleton is the pentacyclic parent nucleus of multiple hydrogen-pinenes. It can either exist in the free form or in the form of saponins inside the plant bodies. In plants, it often co-exists with its isomers hawthorn acid (2α-hydroxy oleanolic acid) with similar structures and chemical properties between each other, thus causing difficulty in separation. In vivo results have shown that corosolic acid promotes the cellular glucose uptake and utilization through stimulating the transport of glucose, thus smoothly achieving its hypoglycemic effect. Its excitatory effects on glucose transport is similar to insulin, therefore, people also call corosolic acid as plant insulin.
    Animal experiments have shown that corosolic acid has a significant hypoglycemic effect on both normal rats and genetically diabetic mice.
    Corosolic acid can also lead to weight loss. Clinical study has found that orally administration of this drug can regulate insulin and blood sugar levels with significant trend of weight loss (average weight loss 0.908-1.816Kg). The whole process is slow and dieting is not necessary. Combination with exercise, drinking a lot of water and regulating the diet with products containing corosolic acid can give rise to the best weight loss efficacy.
    In addition corosolic acid also has many other biological activity, such as inhibitory effects on TPA-induced inflammation whose anti-inflammation effect is stronger than commercially available anti-inflammatory drug, indomethacin; it also has a inhibitory effect on DNA polymerase, as well as inhibitory effects on a variety of tumor cell growth.

    Plant sources

    Lagerstroemia speciosa originates from Asian tropical area and is distributed in India, Sri Lanka, Malaysia, the Philippines and Vietnam. It is routinely cultivated in Guangdong, Guangxi, Yunnan, Hainan and Fujian of china for ornament.
    Lagerstroemia speciosa is a kind of folk medicines among Southeast Asia, and is commonly known as "Barabbas ". In India, people take its roots as a kind of astringent. In Malaysia, people apply pounded leaves for treating malaria, and foot fractures. In the Philippines, the tea drinks made from its leaf is widely used in the treatment and prevention of diabetes, known as the "natural plant insulin"; orally administration is effective with no side effects and can reduce the weight without affecting the appetite. In the 90s of last century, scholars abroad, especially in Japan have conducted extensive researches on it with both its chemical composition and pharmacological effects being reported. Recent studies have found that it can lower blood sugar, cause weight loss; it also has effects of anti-tumor, have anti-inflammatory, anti-viral and anti-cardiovascular disease. Especially should pay attention to its good hypoglycemic activity which has similar physiological effects as insulin, and thus also known as "plant insulin" which draw widespread attention. It has been currently developed into various kinds of health care products both at home and abroad.
    Lagerstroemia speciosa
    Figure 2 Lagerstroemia speciosa

    Reference quality standards

    1. Weight Loss by drying: ≤5%
    2. Heavy metals: ≤10ppm
    3. Agricultural residues: ≤2ppm
    4. Solvent residue: ≤0.5%
    5. Tests of microbes: Total ≤1000CFU/G, mold yeast ≤100CFU/G

    Uses

    (2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tum or activity

    Definition

    ChEBI: A natural product found particularly in Rhododendron species and Eriobotrya japonica.

    Corosolic acid Preparation Products And Raw materials

    Raw materials

    Preparation Products


    Corosolic acid Suppliers

    Global( 247)Suppliers
    Supplier Tel Fax Email Country ProdList Advantage
    Xi'an ZB Biotech Co.,Ltd
    +8618591943808
    sales01@xazbbio.com CHINA 1598 58
    Nanjing Finetech Chemical Co., Ltd.
    025-85710122 17714198479
    025-85710122 sales@fine-chemtech.com CHINA 890 55
    Shanghai Zheyan Biotech Co., Ltd.
    18017610038
    zheyansh@163.com CHINA 3623 58
    Shaanxi Yikanglong Biotechnology Co., Ltd.
    17791478691
    yklbiotech@163.com CHINA 297 58
    Chengdu Biopurify Phytochemicals Ltd.
    18482058008 18080483897
    maggie@biopurify.com CHINA 2712 58
    Nanjing Dolon Biotechnology Co.,Ltd.
    18905173768
    sales@dolonchem.com CHINA 2972 58
    Hubei Jusheng Technology Co.,Ltd.
    86-18871470254
    027-59599243 linda@hubeijusheng.com CHINA 28229 58
    Xi'an Kono chem co., Ltd.,
    13289246953 029-86107037
    info@konochemical.com CHINA 3000 58
    BOC Sciences
    1-631-485-4226
    1-631-614-7828 inquiry@bocsci.com United States 19753 58
    Shanghai Standard Technology Co., Ltd.
    18502101150
    +86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58

    View Lastest Price from Corosolic acid manufacturers

    Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
    2021-09-29 Corosolic acid
    4547-24-4
    US $0.00 / g 1g 98%HPLC 100G WUHAN FORTUNA CHEMICAL CO., LTD
    2021-09-14 Corosolic acid
    4547-24-4
    US $397.00 / g 1g 98% 1000KG Baoji Guokang Healthchem co.,ltd
    2021-07-13 Corosolic acid
    4547-24-4
    US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

    4547-24-4(Corosolic acid)Related Search:


    Copyright 2017 ? ChemicalBook. All rights reserved