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    チオりん酸ジメチル=4-ニトロフェニル

    チオりん酸ジメチル=4-ニトロフェニル 化學構造式
    298-00-0
    CAS番號.
    298-00-0
    化學名:
    チオりん酸ジメチル=4-ニトロフェニル
    別名:
    メタシド;メチルパラチオン;メトロン;チオりん酸=O,O-ジメチル=O-(4-ニトロフェニル);チオりん酸O,O-ジメチルO-[p-ニトロフェニル];ダルフ;デスメチルフェニトロチオン;ホスホロチオ酸O,O-ジメチルO-(4-ニトロフェニル);チオりん酸ジメチル4-ニトロフェニル;メタホス;チオりん酸O-(4-ニトロフェニル)O,O-ジメチル;パラチオン-メチル;パラチオンメチル;ニトロックス80;ジメチルパラチオン;チオりん酸O,O-ジメチルO-(4-ニトロフェニル);チオりん酸ジメチル=4-ニトロフェニル;ホリドールm;メタシド50;ジメチル-p-ニトロフェニルモノチオリン酸塩
    英語化學名:
    Parathion-methyl
    英語別名:
    DALF;e601;a-gro;ME605;Dalif;NITRAN;MPT(R);8056HC;Azofos;Fulkil
    CBNumber:
    CB3348228
    化學式:
    C8H10NO5PS
    分子量:
    263.21
    MOL File:
    298-00-0.mol

    チオりん酸ジメチル=4-ニトロフェニル 物理性質

    融點 :
    36°C
    沸點 :
    143°C (1.0 mmHg)
    比重(密度) :
    1.36
    蒸気圧:
    4.1×10-4 Pa (20 °C)
    屈折率 :
    nD25 1.5367
    閃點 :
    46.1°C
    貯蔵溫度 :
    APPROX 4°C
    外見 :
    solid
    水溶解度 :
    0.005 g/100 mL
    BRN :
    8905814
    安定性::
    Stable. Flammable.
    CAS データベース:
    298-00-0(CAS DataBase Reference)
    IARC:
    3 (Vol. 30, Sup 7) 1987
    NISTの化學物質情報:
    Phosphorothioic acid, o,o-dimethyl-o-p-nitrophenyl ester(298-00-0)
    EPAの化學物質情報:
    Methyl parathion (298-00-0)
    安全性情報
    • リスクと安全性に関する聲明
    • 危険有害性情報のコード(GHS)
    主な危険性  T+;N,N,T+,Xn,F
    Rフレーズ  5-24-26/28-48/22-50/53-10-67-66-51/53-36-20/22-11-65-38
    Sフレーズ  28-36/37-45-60-61-26-62-16
    RIDADR  UN 2052/2783/2811
    WGK Germany  3
    RTECS 番號 TG0175000
    國連危険物分類  6.1(a)
    容器等級  II
    HSコード  29201100
    有毒物質データの 298-00-0(Hazardous Substances Data)
    毒性 LD50 in male, female rats (mg/kg): 14, 24 orally; 67, 67 dermally (Gaines)
    安衛法 57,57-2
    毒劇物取締法 I(特定物)
    絵表示(GHS)
    注意喚起語 Danger
    危険有害性情報
    コード 危険有害性情報 危険有害性クラス 區分 注意喚起語 シンボル P コード
    H225 引火性の高い液體および蒸気 引火性液體 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
    H226 引火性の液體および蒸気 引火性液體 3 警告
    H304 飲み込んで気道に侵入すると生命に危険のおそ れ 吸引性呼吸器有害性 1 危険
    H311 皮膚に接觸すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
    H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
    H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
    H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
    H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
    H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
    H411 長期的影響により水生生物に毒性 水生環境有害性、慢性毒性 2
    注意書き
    P210 熱/火花/裸火/高溫のもののような著火源から遠ざ けること。-禁煙。
    P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
    P273 環境への放出を避けること。
    P280 保護手袋/保護衣/保護眼鏡/保護面を著用するこ と。
    P301+P310 飲み込んだ場合:直ちに醫師に連絡すること。
    P337+P313 眼の刺激が続く場合:醫師の診斷/手當てを受けること。
    P370+P378 火災の場合:消火に...を使用すること。
    P391 漏出物を回収すること。

    チオりん酸ジメチル=4-ニトロフェニル 価格 もっと(19)

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
    富士フイルム和光純薬株式會社(wako) W01ACSAS-E0572 メチルパラチオン Standard
    Methyl parathion Standard, 1000 ug/mL in Acetonitrile
    298-00-0 1mL ¥11800 2021-03-23 購入
    富士フイルム和光純薬株式會社(wako) W01ACSAPP-9-134 メチルパラチオン
    Methyl parathion, 100 ug/mL in MeOH
    298-00-0 1mL ¥11800 2021-03-23 購入
    関東化學株式會社(KANTO) 49801-53 パラチオンメチル標準品
    Parathion methyl standard
    298-00-0 100mg ¥11000 2021-03-23 購入
    Sigma-Aldrich Japan 45891 100?μg/mL in cyclohexane, PESTANAL?, analytical standard
    Parathion-methyl solution 100?μg/mL in cyclohexane, PESTANAL?, analytical standard
    298-00-0 2 mL ¥8300 2021-03-23 購入
    Sigma-Aldrich Japan 40572 certified reference material, 1000?μg/mL in acetone
    Methyl parathion solution certified reference material, 1000?μg/mL in acetone
    298-00-0 1 mL ¥7500 2021-03-23 購入

    チオりん酸ジメチル=4-ニトロフェニル 化學特性,用途語,生産方法

    外観

    白色~うすい黃色, 結晶~結晶性粉末

    溶解性

    水に不溶。脂肪族炭化水素以外の殆どの有機溶剤に可溶。水55mg/l(20℃)。ジクロロメタン, トルエン>200,ヘキサン10~20(共にg/l 20℃)。アセトンに溶け、水にほとんど溶けない。

    用途

    農薬(殺蟲剤)

    農薬用途

    殺蟲剤

    説明

    A case of sensitization to parathion methyl was described in a female agricultural worker with multiple sensitization.

    説明

    Methyl parathion is an organophosphate insecticide. It is converted into an oxon-containing metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase. Methyl parathion is lethal to lab strains and field isolates of tobacco budworm larvae (LD50s = 7 and 81.8-128.3 μg/g, respectively). It reduces the number of stink bugs (C. sayi) caught per 100 net sweeps when applied to alfalfa fields at a concentration of 0.4 pounds per acre. Methyl parathion increases sister chromatid exchange (SCE) in a concentration-dependent manner and induces cell cycle arrest at the M1 phase in V79 cells at a concentration of 40 μg/ml. It is toxic to rats (LD50 = 14 mg/kg).

    化學的特性

    Methyl parathion is a white to yellow-brown, crystalline solid with a garlic odor.It is slightly soluble in water and has a low vapor pressure (U.S. EPA, 2006b).

    使用

    Methyl parathion is a restricted use organophosphate sold under a number of trade names and formulations. First registered in 1954, it is used to control a variety of insect pests on food and feed crops. Methyl parathion is not used in residential settings due to its toxicity to humans, birds, and honey bees. The chemical is a restricted use pesticide with nearly 4 million pounds of active ingredient mainly used on cotton, corn, wheat, soybeans, and rice (U.S. EPA, 2006b).

    使用

    Parathion-methyl is an derivative of Parathion (P192220), an organophosphate insecticide used on cotton, rice and fruit trees.

    使用

    Methyl parathion is an insecticide and acaricide used to control boll weevils and many biting or sucking insect pests of agricultural crops. It kills insects by contact, stomach and respiratory action. Methyl parathion is available in dust, emulsifiable concentrate, ULV liquid, microencapsules and wettable powder formulations.
    Methyl parathion is one of a class of insecticides referred to as organophosphates. These chemicals act by interfering with the activities of cholinesterase, an enzyme that is essential for the proper working of the nervous systems of humans, animals and insects.

    定義

    ChEBI: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.

    一般的な説明

    Methyl parathion is a white crystalline solid dissolved in a liquid solvent carrier. The commercial product is a tan liquid (xylene solution) with a pungent odor. Parathion-methyl is slightly soluble to insoluble in water. Usually with the liquid solvent Parathion-methyl is a combustible liquid. Parathion-methyl is toxic by inhalation, ingestion and skin absorption. Parathion-methyl is used as an insecticide.

    空気と水の反応

    Insoluble in water.

    反応プロフィール

    METHYL PARATHION is half decomposed in 8 days at 40°C. When a sample was heated in a small test tube Parathion-methyl decomposed in a few minutes, the residue exploded (Food Chem. 4(1):42. 1956).

    危険性

    Explosion risk when heated. Toxicby skin absorption, inhalation, and ingestion;cholinesterase inhibitor. Use has been restricted.Questionable carcinogen.

    健康ハザード

    Parathion-methyl is extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. Chronic toxicity does not appear to be a major consideration.

    火災危険

    Poisonous gases are produced in fire and when heated. Decomposition may lead to sufficient internal pressure to cause the container to rupture violently. Avoid oxidizing materials. Unstable. High temperatures (120F) cause decomposition.

    農業用途

    Insecticide, Nematicide: A U.S. EPA restricted Use Pesticide (RUP). Severely Restricted for use in EU, as parathion-methyl. This material is used as an insecticide on over 50 crops, primarily cotton, but also on walnuts, corn, dried beans and almonds and on several ornamentals. It is no longer allowed to be used on crops consumed by children.

    製品名

    A-GRO®[C]; AI3-17292®; ATOMIC®[C]; AZOFOS®; AZOPHOS; BAMA BRAND®[C]; BAY 11405®; BAY E-601®; BLADAN M®; CEKUMETHION®; CLEAN CROP®[C]; COTTON TOX DUST®[C]; DALF®; DECLARE®; DEVITHION®; DREXEL METHYL PARATHION 4E®[C]; DURHAM[C]; E 601®; EMMY®[C]; E-Z-FLO®[C]; FALL OUT®[C]; FMC NYNAMITE®[C]; FOLIDOC®; FOLIDOL-80®; FOLIDOL M®; FOLIDOL M-40®; FOSFERNO M 50®; GEARPHOS®; 8056HC®; KILEX PARATHION®; ME-PARATHION®; MEPTOX®; METACID 50®; METACIDE®; METAFOS®; METAPHOS®; METRON®; METHYL-E 605®; METRON®; NITROX®; NITROX® 80; OLEOVOFOTOX®; PARAPEST M-50®; PENNCAP M®; PENNCAP MLS®; QUINOPHOS®; SEIS-TRES 6-3®; SINAFID M-48®; SIXTY-THREE SPECIAL E. C. INSECTICIDE®; TEKWAISA®; THIOPHENIT®; THYLPAR M-50®; TOLL®; VERTAC METHYL PARATHION TECHNISCH 80%®; WOFATOX 50 EC®

    接觸アレルゲン

    A case of sensitization to methyl-parathion was described in a female agricultural worker with multiple sensitization.

    安全性プロファイル

    Poison by inhalation, ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. Fatal poisoning can result from skin or eye contact after very brief exposure to concentrated solution. Experimental teratogenic and reproductive effects. Questionable carcinogen. Human mutation data reported. A cholinesterase inhibitor type of insecticide. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.

    職業ばく露

    A severely hazardous pesticide formulation. Alert: This material is used as an insecticide on over 50 crops, primarily cotton, and on several ornamentals

    Carcinogenicity

    When rats were given diets with 0, 0.5, 2.5, 12.5, and 50 ppm (0, 0.02, 0.1, 0.5, or 2 mg/kg/day (males); 0, 0.02, 0.1, 0.7, or 3 mg/kg/day (females) for 12 months, neuronal degeneration and plasma, erythrocyte, and brain cholinesterase inhibition occurred at 12.5 and 50 ppm .

    環境運命予測

    Methyl parathion is mobile in soils and can leach into groundwater and enter surface water as runoff. The chemical breaks down though microbial degradation, aqueous photolysis, hydrolysis, and incorporation into soil organic matter; thus, it degrades rapidly in soil and water with a half-life <5 days. Photodegradation is rapid in aquatic environments with a half-life of 49 h. Bioconcentration is not expected to occur (U.S. EPA, 2006b).

    代謝経路

    Parathion-methyl is a non-systemic insecticide and, where studied, metabolism parallels that of parathion and f enitrothion. The major routes of biotransformation involve desulfuration to the oxon analogue (paraoxon-methyl) and hydrolysis to give dimethyl phosphate, dimethyl phosphorothionate and 4-nitrophenol. Demethylation to give desmethylparathion- methyl and reduction of the nitro group also occurs. As with organophosphates, demethylation via glutathione-S-methyl transferases in the liver and some other tissues is an important mechanism in mammals. The major route of phase II metabolism involves conjugation of 4-nitrophenol followed by excretion.

    輸送方法

    UN3017 Organophosphorus pesticides, liquid, toxic, flammable, flash point not ,23C, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3.-Flammable liquid. UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous material. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required

    Degradation

    Parathion-methyl (1) is hydrolysed under acidic and alkaline conditions. The rate is five times faster than for parathion. Upon heating it isomerises via a thonwthiolo rearrangement to yield S-methylparahon-methyl (2) (PM). The hydrolysis of the active anticholinesterase oxon analogue (paraoxon-methyl) (3) is much faster than that of parathion-methyl. The products of parathion-methyl hydrolysis were 4-nitrophenol (4) and dimethyl phosphorothioate (5) (Thuma et al., 1983). Hydrolysis is much more rapid in alkaline than in acidic or neutral media. Photodegradation in natural sunlight led to the formation of O,O,S-trimethyl phosphorothioate (6) and trimethyl phosphate (7) (Chukwudebe et al., 1989). Zweiner et al. (1994) examined the photolysis of parathion-methyl in aqueous solution after irradiation by unfiltered UV light. The major metabolites, which were detected by GC-MS, were paraoxon-methyl (3) and 4-nitrophenol (4). These conversions are shown in Scheme 1.

    不和合性

    Incompatible with oxidizers, strong bases; heat. Mixtures with magnesium, or endrin may be violent or explosive. Slightly decomposed by acid solutions. Rapidly decomposed by alkalies. Explosive risk when heated above 50C. The liquid xylene solution decomposes violently @ 120C

    廃棄物の処理

    Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration (816C, 0.5 second minimum for primary combustion; 1204C, 1.0 second for secondary combustion) with adequate scrubbing and ash disposal facilities. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

    チオりん酸ジメチル=4-ニトロフェニル 上流と下流の製品情報

    原材料

    準備製品


    チオりん酸ジメチル=4-ニトロフェニル 生産企業

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    298-00-0(チオりん酸ジメチル=4-ニトロフェニル)キーワード:


    • 298-00-0
    • NITROX 80(R)
    • NITRAN
    • O,O-DIMETHYL O-(4-NITROPHENYL)-PHOSPHOROTHIOATE
    • O,O-DIMETHYL-O-P-NITROPHENYL PHOSPHOROTHIOATE(R)
    • O,O-Dimethyl O-(p-nitrophenyl) thionophosphate
    • PARASHOOT(R)
    • PARATHION-METHYL
    • PARTON(R)
    • PARIDOL(R)
    • MPT(R)
    • oleovofotox
    • OMS 213
    • parapestm-50
    • Parataf
    • Parathion methyl homolog
    • parathionmethylhomolog
    • parathion-metile
    • Paratox
    • parton-m
    • Partron M
    • partronm
    • Pencap M
    • Penncap M
    • PhosphorothioicacidO,O-dimethylO-(4-nitro-phenyl)esenyl)ester
    • phosphorothioicacido,o-dimethylo-(4-nitrophenyl)ester
    • p-nitrophenyldimethylthionophosphate
    • quinophos
    • rcrawastenumberp071
    • Sinafid M-48
    • sinafidm-48
    • メタシド
    • メチルパラチオン
    • メトロン
    • チオりん酸=O,O-ジメチル=O-(4-ニトロフェニル)
    • チオりん酸O,O-ジメチルO-[p-ニトロフェニル]
    • ダルフ
    • デスメチルフェニトロチオン
    • ホスホロチオ酸O,O-ジメチルO-(4-ニトロフェニル)
    • チオりん酸ジメチル4-ニトロフェニル
    • メタホス
    • チオりん酸O-(4-ニトロフェニル)O,O-ジメチル
    • パラチオン-メチル
    • パラチオンメチル
    • ニトロックス80
    • ジメチルパラチオン
    • チオりん酸O,O-ジメチルO-(4-ニトロフェニル)
    • チオりん酸ジメチル=4-ニトロフェニル
    • ホリドールm
    • メタシド50
    • ジメチル-p-ニトロフェニルモノチオリン酸塩
    • パラチオンメチル標準品
    • ジメチルパラニトロフェニルチオホスフェイト
    • ジメチルpニトロフェニルモノチオリン酸
    • ???????????????????????(?????????)
    • ジメチルパラニトロフェニルチオホスフェイト、
    • ジメチルパラニトロフェニルチオホスフェイト、またはそれを含有する製剤
    • ジメチル‐パラ‐ニトロフェニルチオホスフェイト (別名 メチルパラチオン)
    • CS_N-12452-100MG_メチルパラチオンパラチオンメチル
    • パラチオンメチルメチルパラチオン
    • メチルパラチオン標準品
    • メチルパラチオン STANDARD
    • パラチオンメチル 溶液
    • メチルパラチオン 溶液
    • メチルパラチオン Standard, 100 μg/mL in MeOH
    • メチルパラチオン Standard, 1000 μg/mL in Acetonitrile
    • メチルパラチオン Standard, 1000 μg/mL in Hexane
    • メチルパラチオン Standard, 1000 μg/mL in MeOH
    • メチルパラチオン, 100 μg/mL in MeOH
    • コリンエステラーゼ阻害剤
    • 有機リン系殺蟲剤
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