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    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩

    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩 化學構造式
    50-62-4
    CAS番號.
    50-62-4
    化學名:
    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩
    別名:
    レオキシル;ヘキソベンジン二塩酸塩;塩酸ヘキソベンジン;ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩
    英語化學名:
    hexobendine dihydrochloride
    英語別名:
    Reoxyl;Ustimon;Andiamine;Hexobendin Hydrochloride;HEXOBENDINEHYDROCHLORIDE;hexobendine dihydrochloride;Hexobendine-d18 Dihydrochloride;3,3'-[Ethylenebis(MethyliMino)]di-1-propanol Bis(3,4,5-triMethoxybenzoate) (Ester) Dihydrochloride;3,4,5-TriMethoxybenzoic Acid 1,2-Ethanediylbis[(MethyliMino)-3,1-propanediyl] Ester Dihydrochloride;3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate dihydrochloride
    CBNumber:
    CB4939117
    化學式:
    C30H44N2O10.2ClH
    分子量:
    665.603
    MOL File:
    50-62-4.mol

    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩 物理性質

    融點 :
    170-174°

    安全性情報

    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩 価格 もっと(2)

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
    富士フイルム和光純薬株式會社(wako) W01TRCH295450 ヘキソベンジン二塩酸塩
    Hexobendine Dihydrochloride
    50-62-4 25mg ¥41300 2021-03-23 購入
    富士フイルム和光純薬株式會社(wako) W01TRCH295450 ヘキソベンジン二塩酸塩
    Hexobendine Dihydrochloride
    50-62-4 250mg ¥330000 2021-03-23 購入

    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩 化學特性,用途語,生産方法

    Originator

    Reoxyl,Hormonchemie,W. Germany,1966

    使用

    Hexobendine dihydrochloride is used as vasodilator (coronary).

    Manufacturing Process

    Methylacrylate and N,N'-dimethylethylenediamine are first reacted and that product reduced with lithium aluminum hydride to give a compound A.
    To a solution of 13 parts of compound A and 12 parts by volume of absolute pyridine in 80 parts by volume of absolute dioxane there are added dropwise and under constant stirring 35 parts of 3,4,5-trimethoxybenzoyl chloride dissolved in 70 parts by volume of absolute dioxane in the course of 30 minutes. The mixture is stirred for a further 3 hours at a temperature of 100°C and the excess solvent is then evaporated in vacuo. The residue of the evaporation is treated with ethyl acetate and saturated sodium carbonate solution, whereafter the organic phase is separated, treated with water, dried with sodium sulfate and the solvent is removed in vacuo. The residue thus obtained is taken up in ether and separated from 4 parts of insoluble trimethoxybenzoic acid anhydride by filtration. After evaporation of the ether there are obtained 32.5 parts of N,N'-dimethyl-N,N'-bis-[3-(3,4,5- trimethoxybenzoxy)propyl]-ethylene diamine, corresponding to a yield of 86% of the theoretical. MP: 75°C to 77°C.
    The di-tertiary base thus obtained is dissolved in ether and the solution is saturated with hydrogen chloride gas. After isolation and reprecipitation from methanol-ether there is obtained the dihydrochloride melting at 170°C to 174°C.

    Therapeutic Function

    Vasodilator

    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩 上流と下流の製品情報

    原材料

    準備製品


    ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩 生産企業

    Global( 7)Suppliers
    名前 電話番號 ファックス番號 電子メール 國籍 製品カタログ 優位度
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    Energy Chemical 400-005-6266 021-58432009-
    021-58436166 marketing@energy-chemical.com China 44747 58

    • 50-62-4
    • hexobendine dihydrochloride
    • Andiamine
    • Ustimon
    • HEXOBENDINEHYDROCHLORIDE
    • Reoxyl
    • 3,4,5-trimethoxybenzoic acid 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl ester dihydrochloride
    • 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate dihydrochloride
    • 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxyphenyl)carbonyloxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate dihydrochloride
    • 3,3'-[Ethylenebis(MethyliMino)]di-1-propanol Bis(3,4,5-triMethoxybenzoate) (Ester) Dihydrochloride
    • 3,4,5-TriMethoxybenzoic Acid 1,2-Ethanediylbis[(MethyliMino)-3,1-propanediyl] Ester Dihydrochloride
    • Hexobendin Hydrochloride
    • Hexobendine-d18 Dihydrochloride
    • レオキシル
    • ヘキソベンジン二塩酸塩
    • 塩酸ヘキソベンジン
    • ビス(3,4,5-トリメトキシ安息香酸)エチレンビス[(メチルイミノ)-3,1-プロパンジイル]·2塩酸塩
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