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    葉酸水和物

    葉酸水和物 化學構造式
    59-30-3
    CAS番號.
    59-30-3
    化學名:
    葉酸水和物
    別名:
    葉酸水和物;フォリアミン;N-[4-(2-アミノ-4-オキソ-1,4-ジヒドロプテリジン-6-イルメチルアミノ)ベンゾイル]-L-グルタミン酸;プテロイルグルタミン酸;N-[4-[[(2-アミノ-1,4-ジヒドロ-4-オキソプテリジン-6-イル)メチル]アミノ]ベンゾイル]-L-グルタミン酸;N-[4-[(2-アミノ-4-ヒドロキシプテリジン-6-イル)メチルアミノ]ベンゾイル]-L-グルタミン酸;ビタミンM;ビタミンBc;葉酸;ホラシン;N-プテロイル-L-グルタミン酸;ビタミン M(葉酸);ビタミンB9水和物;ビタミンM水和物;プテロイル-L-グルタミン酸水和物;ビタミン M;葉酸標準品;葉酸 (JP17)
    英語化學名:
    Folic acid
    英語別名:
    PGA;Folan;folic;Aspol;PTEGLU;FOLSAN;Folate;Folbal;Folsav;VM/PGA
    CBNumber:
    CB5100903
    化學式:
    C19H19N7O6
    分子量:
    441.4
    MOL File:
    59-30-3.mol

    葉酸水和物 物理性質

    融點 :
    250 °C
    比旋光度 :
    20 º (c=1, 0.1N NaOH)
    沸點 :
    552.35°C (rough estimate)
    比重(密度) :
    1.4704 (rough estimate)
    屈折率 :
    1.6800 (estimate)
    貯蔵溫度 :
    2-8°C
    溶解性:
    boiling water: soluble1%
    酸解離定數(Pka):
    pKa 2.5 (Uncertain)
    外見 :
    Crystalline Powder
    色:
    Yellow to orange
    臭い (Odor):
    Odorless
    酸塩基指示薬変色域(pH):
    4
    水溶解度 :
    1.6 mg/L (25 ºC)
    Merck :
    14,4221
    BRN :
    100781
    安定性::
    Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
    InChIKey:
    OVBPIULPVIDEAO-LBPRGKRZSA-N
    CAS データベース:
    59-30-3(CAS DataBase Reference)
    NISTの化學物質情報:
    Folic acid(59-30-3)
    EPAの化學物質情報:
    L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)
    安全性情報
    • リスクと安全性に関する聲明
    • 危険有害性情報のコード(GHS)
    Rフレーズ  33-62-68
    Sフレーズ  24/25
    WGK Germany  1
    RTECS 番號 LP5425000
    8
    TSCA  Yes
    HSコード  29362900
    有毒物質データの 59-30-3(Hazardous Substances Data)
    絵表示(GHS)
    注意喚起語 Warning
    危険有害性情報
    コード 危険有害性情報 危険有害性クラス 區分 注意喚起語 シンボル P コード
    H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
    H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
    H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
    注意書き
    P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
    P305+P351+P338 眼に入った場合:水で數分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

    葉酸水和物 価格 もっと(38)

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
    富士フイルム和光純薬株式會社(wako) W01W0106-0180 葉酸 98.0~102.0% (calculated on the dehydrous basis)(Absorptiometry)
    Folic Acid 98.0~102.0% (calculated on the dehydrous basis)(Absorptiometry)
    59-30-3 1g ¥2150 2021-03-23 購入
    富士フイルム和光純薬株式會社(wako) W01W0106-0180 葉酸 98.0~102.0% (calculated on the dehydrous basis)(Absorptiometry)
    Folic Acid 98.0~102.0% (calculated on the dehydrous basis)(Absorptiometry)
    59-30-3 25g ¥4250 2021-03-23 購入
    東京化成工業 F0043 葉酸水和物 >98.0%(HPLC)(T)
    Folic Acid Hydrate >98.0%(HPLC)(T)
    59-30-3 25g ¥5800 2021-03-23 購入
    関東化學株式會社(KANTO) 16227-30 葉酸 98.0%~102.0%(UV‐VIS)
    Folic acid 98.0%~102.0%(UV‐VIS)
    59-30-3 25g ¥4400 2021-03-23 購入
    Sigma-Aldrich Japan 47866 analytical standard
    Folic acid analytical standard
    59-30-3 500 mg ¥6900 2021-03-23 購入

    葉酸水和物 化學特性,用途語,生産方法

    外観

    黃色~赤みの黃色, 粉末

    定義

    本品は、グルタミン酸誘導體であり、次の化學式で表される。

    溶解性

    うすい水酸化ナトリウム溶液、うすい塩酸及びうすい硫酸に溶け、水及びエタノールにほとんど溶けない。

    解説

    化學式はC19H19N7O6。ビタミンB複合體の一つ。ビタミンM,ビタミンB(/c)とも呼ばれた。パラアミノ安息香酸にプテリンとグルタミン酸が結合したもので,水や多くの有機溶媒に難溶。酵母,糸狀菌,肝臓,卵,アスパラガス,ホウレンソウなどに含まれる。核酸塩基の代謝に関係し,赤血球母細胞の成熟などに必要。また乳酸菌など微生物の増殖促進因子としても知られる。栄養失調癥,悪性貧血などにビタミンB12,肝臓エキスと併用される?!v連項目悪性貧血|造血薬|ビタミン|プテリン
    株式會社平凡社 百科事典マイペディアについて 情報

    用途

    薬理?生理作用研究用。

    用途

    核酸代謝に作用します。

    化粧品の成分用途

    皮膚コンディショニング剤

    効能

    貧血治療薬, 造血薬, 葉酸補充薬

    商品名

    フォリアミン (日本製薬); フォリアミン (日本製薬)

    説明

    In the 1930s, brewer’s yeast was found to prevent anemia. Folic acid was later discovered to be the nutrient responsible for this effect and was purified in 1941 by Mitchell and coworkers (Mitchell et al., 1941). Folate is needed for biosynthesis of purines and thymidine for DNA and RNA synthesis in all cells. It is also involved in metabolism of some of the amino acids needed for protein synthesis, especially the conversions of serine to glycine and homocysteine to methionine. This makes the nutrient especially important during periods of rapid cell division, such as in pregnancy. Folate is also involved in transfer of one-carbon groups for methylation reactions. The role of folate in cell division was capitalized upon in the synthesis of aminopterin, a folate antagonist, which was one of the first anticancer drugs produced.

    説明

    Folic acid is an essential B vitamin. It is converted to folate in vivo, which is a necessary cofactor for a variety of biological processes, including nucleotide synthesis and, thus, DNA synthesis and repair, among others. A deficiency in dietary folic acid can lead to a range of developmental and cognitive disorders, most prominently neural tube defects and congenital heart defects.

    化學的特性

    orange to yellow crystalline powder

    物理的性質

    The folates include a large number of chemically related species, each differing with respect to the various substituents possible at three sites on the pteroylglutamic acid basic structure. More than 170 different folates are theoretically possible. Not all of these occur in nature; but it has been estimated that as many as 100 different forms are found in animals. The folates from most natural sources usually have a single carbon unit at N-5 and/or N-10; these forms participate in the metabolism of the single-carbon pool.
    Folic acid (pteroylmonoglutamic acid) is an orange-yellow crystalline substance that is soluble in water but insoluble in ethanol or less polar organic solvents. It is unstable to light, to acidic or alkaline conditions, to reducing agents, and, except in dry form, to heat. It is reduced in vivo enzymatically (or in vitro with a reductant such as dithionite) first to 7,8-dihydrofolic acid (FH2) and then to FH4; both of these compounds are unstable in aerobic environments and must be protected by the pres ence of an antioxidant (e.g., ascorbic acid, 2-mer
    Two derivatives of folic acid, each having an amino group in the place of the hydroxyl at C-4, are folate antagonists of biomedical use: aminopterin (4-aminofolic acid) and methotrexate (4-amino-N10-methylfolic acid). Aminopterin is used as a rodenticide; methotrexate is an antineoplastic agent.

    Originator

    Folvite, Lederle, US ,1946

    天然物の起源

    Synthetic

    使用

    Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.

    使用

    Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.

    使用

    folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.

    使用

    A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

    使用

    hematopoietic vitamin

    定義

    ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

    Manufacturing Process

    The following description is taken from US Patent 2,956,057.
    100 grams of 1,3,3-trichloroacetone are heated on a boiling water bath and 95 grams of bromine are added thereto in drops while being stirred and the stirring is continued for about 1 hour. The resulting reaction solution is distilled under reduced pressure. 115 grams of 1-bromo-1,3,3- trichloroacetone are obtained having a boiling point of 85° to 95°C/17 mm (Hg).
    For the preparation of the hydrate, 100 grams of water are added to 100 grams of 1bromo-1,3,3-trichloroacetone, which is agitated and cooled. A white scaly crystal of hydrate of 1-bromo-1,3,3-trichloroacetone is obtained (100 grams), having a melting point of 52° to 53°C.
    8.9 grams of 2,4,5-triamino-6-hydroxypyrimidine hydrochloride and 8 grams of p-aminobenzoylglutamic acid are dissolved in 400 cc warm water, which is cooled at 35° to 27°C and adjusted to pH 4 by using 20% caustic soda solution. To this solution was simultaneously added dropwise a solution obtained by dissolving 13.4 grams of 1-bromo-1,3,3-trichloroacetone hydrate in 90 cc of 50% methanol and 24 grams of 35% aqueous sodium bisulfite solution over a period of approximately 2 hours. During this period, in order to maintain the pH value of the reaction solution at 4 to 5, 20% caustic soda solution is added from time to time. The precipitate, formed by stirring for 5 hours after dropping was finished, is filtered, and the filtrated precipitate is refined; 5.6 grams of pure pteroylglutamic acid is obtained.

    Therapeutic Function

    Treatment of B vitamin (folacin) deficiency

    一般的な説明

    Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

    空気と水の反応

    Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

    反応プロフィール

    Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.

    火災危険

    Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

    Biochem/physiol Actions

    A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.

    安全性プロファイル

    Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

    Veterinary Drugs and Treatments

    Folic acid is used to treat folic acid deficiency in dogs, cats, and horses (theoretically in other animal species as well) often due to small intestinal disease. Cats with exocrine pancreatic insufficiency appear to be most at risk for folate and cobalamin deficiencies secondary to malabsorption of folic acid in the diet. Dogs with exocrine pancreatic insufficiency often are noted to have increased folate levels secondary to overgrowths of folate-synthesizing bacteria in the proximal small intestine. Chronic administration of dihydrofolate reductase inhibiting drugs such as pyrimethamine, ormetoprim or trimethoprim can potentially lead to reduced activated folic acid (tetrahydrofolic acid); folic acid supplementation is sometimes prescribed in an attempt to alleviate this situation.

    純化方法

    If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

    葉酸水和物 上流と下流の製品情報

    原材料

    準備製品


    葉酸水和物 生産企業

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    59-30-3(葉酸水和物)キーワード:


    • 59-30-3
    • EZNA KIT FUNGAL DNA MINI
    • KIT BLOOD DNA EZNA 5 TESTS
    • PTEROYL-L-GLUTAMIC ACID
    • PTEROYLMONOGLUTAMIC ACID
    • PTEROYLGLUTAMIC ACID
    • PTEROYGLUTAMIC ACID
    • PTEGLU
    • PGA
    • nzoyl]-
    • Pteroyl-L-monoglutamic acid
    • pteroyl-l-monoglutamicacid
    • USAF cb-13
    • usafcb-13
    • Vitamin Be
    • vitaminbe
    • NATURALFOLATEFROMFOOD
    • FOLICACIDSUPPLEMENTS
    • PTEROYLMONOGLUTAMATE
    • FOLSAEURE
    • Folsure
    • 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino PteGlu Pteroyl-L-glutamic acid Vitamin M PGA Pteroylglutamic acid Folic Acid Hydrate
    • Folic acids
    • Vitamin B
    • FMOC-XANTHYL-L-CYSTEINE
    • Folic acid >98%
    • Acidum folicum, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
    • PteGlu, Pteroyl-L-glutamic acid, Vitamin M
    • Vitamin M (Folic Acid)
    • N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]glutamic acid
    • N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]gluamic acid
    • 葉酸水和物
    • フォリアミン
    • N-[4-(2-アミノ-4-オキソ-1,4-ジヒドロプテリジン-6-イルメチルアミノ)ベンゾイル]-L-グルタミン酸
    • プテロイルグルタミン酸
    • N-[4-[[(2-アミノ-1,4-ジヒドロ-4-オキソプテリジン-6-イル)メチル]アミノ]ベンゾイル]-L-グルタミン酸
    • N-[4-[(2-アミノ-4-ヒドロキシプテリジン-6-イル)メチルアミノ]ベンゾイル]-L-グルタミン酸
    • ビタミンM
    • ビタミンBc
    • 葉酸
    • ホラシン
    • N-プテロイル-L-グルタミン酸
    • ビタミン M(葉酸)
    • ビタミンB9水和物
    • ビタミンM水和物
    • プテロイル-L-グルタミン酸水和物
    • ビタミン M
    • 葉酸標準品
    • 葉酸 (JP17)
    • ビタミン
    • 生化學
    • ビタミンB群
    • 代謝作用薬
    • 造血薬
    • 植物成長調整剤
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