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    カフェイン酸

    カフェイン酸 化學構造式
    331-39-5
    CAS番號.
    331-39-5
    化學名:
    カフェイン酸
    別名:
    カフェイン酸;3,4-ジヒドロキシ-trans-けい皮酸;3-(3,4-ジヒドロキシフェニル)プロペン酸;3-(3,4-ジヒドロキシフェニル)アクリル酸;3,4-ジヒドロキシベンゼンアクリル酸;カフェー酸;3,4-ジヒドロキシけい皮酸;コーヒー酸;trans-カフェー酸;(E)-3-[3,4-ジヒドロキシフェニル]アクリル酸;(E)-3-(3,4-ジヒドロキシフェニル)アクリル酸;(E)-3,4-ジヒドロキシけい皮酸;(E)-3-(3,4-ジヒドロキシフェニル)プロペン酸;3-(3,4-ジヒドロキシフェニル)-2-プロペン酸;カフェ酸;3,4‐ジヒドロキシけい皮酸;カフェ酸標準品;カフェー酸 (AHP VERIFIED)
    英語化學名:
    Caffeic acid
    英語別名:
    Caffeic;31-39-5;NSC 623438;CAFFIC ACID;CAFFEIC ACID;AKOS B004050;Caffeic acid 0;cis-caffeicaci;Caffeicacid,96%;CaffeicAcidPure
    CBNumber:
    CB6281061
    化學式:
    C9H8O4
    分子量:
    180.16
    MOL File:
    331-39-5.mol

    カフェイン酸 物理性質

    融點 :
    211-213 °C (dec.) (lit.)
    沸點 :
    272.96°C (rough estimate)
    比重(密度) :
    1.2933 (rough estimate)
    屈折率 :
    1.4500 (estimate)
    貯蔵溫度 :
    2-8°C
    溶解性:
    ethanol: 50 mg/mL
    酸解離定數(Pka):
    4.58±0.10(Predicted)
    外見 :
    powder
    色:
    yellow to tan
    水溶解度 :
    soluble in hot water
    Merck :
    14,1635
    BRN :
    2210883
    安定性::
    Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
    InChIKey:
    QAIPRVGONGVQAS-DUXPYHPUSA-N
    CAS データベース:
    331-39-5(CAS DataBase Reference)
    IARC:
    2B (Vol. 56) 1993
    NISTの化學物質情報:
    Cinnamic acid, 3,4-dihydroxy-(331-39-5)
    EPAの化學物質情報:
    2-Propenoic acid, 3-(3,4-dihydroxyphenyl)- (331-39-5)
    安全性情報
    • リスクと安全性に関する聲明
    • 危険有害性情報のコード(GHS)
    主な危険性  Xn,Xi
    Rフレーズ  36/37/38-40-63-68
    Sフレーズ  26-36/37/39-36
    WGK Germany  3
    RTECS 番號 GD8950000
    Hazard Note  Irritant
    HSコード  29182990
    有毒物質データの 331-39-5(Hazardous Substances Data)
    絵表示(GHS)
    注意喚起語 Warning
    危険有害性情報
    コード 危険有害性情報 危険有害性クラス 區分 注意喚起語 シンボル P コード
    H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
    H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
    H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
    H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
    H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
    注意書き
    P201 使用前に取扱説明書を入手すること。
    P202 全ての安全注意を読み理解するまで取り扱わないこ と。
    P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
    P264 取扱い後は皮膚をよく洗うこと。
    P264 取扱い後は手や顔をよく洗うこと。
    P308+P313 暴露または暴露の懸念がある場合:醫師の診斷/手當てを 受けること。
    P405 施錠して保管すること。
    P501 內容物/容器を...に廃棄すること。

    カフェイン酸 価格 もっと(36)

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
    富士フイルム和光純薬株式會社(wako) W01APOOR1165 3,4-ジヒドロキシけい皮酸
    3,4-Dihydroxycinnamic acid
    331-39-5 10g ¥26900 2021-03-23 購入
    富士フイルム和光純薬株式會社(wako) W01APOOR1165 3,4-ジヒドロキシけい皮酸
    3,4-Dihydroxycinnamic acid
    331-39-5 50g ¥92200 2021-03-23 購入
    東京化成工業 C0002 カフェイン酸 >98.0%(HPLC)(T)
    Caffeic Acid >98.0%(HPLC)(T)
    331-39-5 5g ¥3700 2021-03-23 購入
    東京化成工業 C0002 カフェイン酸 >98.0%(HPLC)(T)
    Caffeic Acid >98.0%(HPLC)(T)
    331-39-5 25g ¥12400 2021-03-23 購入
    関東化學株式會社(KANTO) 10281-52 3,4‐ジヒドロキシけい皮酸 >98.0%(HLC)
    3,4‐Dihydroxycinnamic acid >98.0%(HLC)
    331-39-5 5g ¥2700 2021-03-23 購入

    カフェイン酸 MSDS


    Caffeic acid

    カフェイン酸 化學特性,用途語,生産方法

    外観

    うすい黃色~うすい褐色, 粉末

    定義

    本品は、次の化學式で表される芳香族化合物である。

    溶解性

    エタノール及びアセトンにやや溶けやすく、水にほとんど溶けない。

    用途

    有機合成原料。

    化粧品の成分用途

    酸化防止剤、香料

    説明

    Caffeic acid is abundant in the whole plant of Solidago decurrens Lour. (Yi Zhi Huang Hua), fruit of Crataegus pinnatifida Bge. var. major N.E.Br. (Shan Li Hong), Salix myrtillacea Anderss. (Po Liu), rhizome of Cimicifuga foetida L., rhizome of Polypodiaceae Polypodium vulgare L. (Ou Ya Shui Long Gu), peel of Rutaceae Citrus limonum (Ning Meng), the whole plant of Polygonaceae Polygonum aviculare L. (Pian Xu), root of Valeriana officinalis L. (Xie Cao), the whole plant of Thymus mongolicus Ronn (She Xiang), leaves of Eucommia ulmoides (Du Zhong), and other herbal plants. It is a kind of polyhydroxy styrene acid, with the general chemical properties of phenolic acid. It is easily oxidized for the reason of the unsaturated double bonds, particularly unstable in alkaline solution
    Caffeic acid has both cis and trans isomers, and the two isomers of caffeic acid have a mutual transformation in plants, which may regulate some important physiological process. Caffeic acid exists in plants in the main form of complexes; free state accounts for a few proportion.

    説明

    Caffeic acid is an inhibitor of 5-LO with an IC50 value of 3.7-72 μM and 12-LO with an IC50 value of 5.1-30 μM.

    化學的特性

    Light yellow to greenish-yellow powder

    物理的性質

    Appearance: yellow crystal. The crystal from the concentrated solution does not contain crystal water, and the crystal from the dilute solution contains one molecule crystal water. Melting point: 223?225?°C. Solubility: It is slightly soluble in cold
    water but soluble in hot water, cold ethanol, and ethyl acetate. The basic solution is orange-red. Ferric chloride solution was dark green.

    使用

    Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis. It has also been used to determine its antioxidant activity by various assay methods.

    使用

    antineoplastic, PGE2 synthase inhibitor, PK inhibitor

    使用

    Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi.

    適応癥

    It is used for preventing or stopping bleeding during surgery, as well as hemostasis in the department of medicine, obstetrics and gynecology, etc. It is also used for various causes of neutropenia and thrombocytopenia.

    一般的な説明

    Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.

    空気と水の反応

    Insoluble in water.

    反応プロフィール

    Caffeic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Caffeic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

    健康ハザード

    ACUTE/CHRONIC HAZARDS: When heated to decomposition Caffeic acid emits acrid smoke and fumes.

    火災危険

    Flash point data for Caffeic acid are not available; however, Caffeic acid is probably combustible.

    Biochem/physiol Actions

    A natural dietary phenolic compound found in plants that is an anti-oxidant. Inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy. Inhibits Cu2+-induced LDL oxidation.

    純化方法

    Recrystallise this antioxidant from water. [Beilstein 10 IV 1776.]

    カフェイン酸 上流と下流の製品情報

    原材料

    準備製品


    カフェイン酸 生産企業

    Global( 555)Suppliers
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    331-39-5(カフェイン酸)キーワード:


    • 331-39-5
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    • TIMTEC-BB SBB006475
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    • CAFFEIC ACID
    • 3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID
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    • CAFFEIC ACID, MATRIX SUBSTANCE FOR MALDI -MS
    • 3,4-DIHYDROXYCINNAMIC ACID, 97%, PREDOMINANTLY TRANS
    • 3,4-DIHYDROXYCINNAMIC ACID (CAFFEIC ACID)
    • CaffeicAcidPure
    • CAFFIC ACID
    • 3,4-Dihydroxycinnamic acid, predominantly trans isomer, 99+%
    • LABOTEST-BB LT00233168
    • 3,4-DIHYDROXYCINNAMIC ACID
    • AKOS B004050
    • NSC 623438
    • (Z)-3-(3,4-dihydroxyphenyl)acrylic acid
    • Caffeic
    • CAFFEICACID(BULK
    • Caffeic acid 0
    • (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
    • Caffeic acid, 99%, predoMinantly trans
    • Caffeic acid, predoMinantly trans
    • (2E)-3-(3,4-Dihydroxyphenyl)-2-propenoic acid
    • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-
    • 3-(3,4-dihydroxyphenyl)-2-propenoicaci
    • 3-(3,4-Dihydroxyphenyl)propenoic acid
    • カフェイン酸
    • 3,4-ジヒドロキシ-trans-けい皮酸
    • 3-(3,4-ジヒドロキシフェニル)プロペン酸
    • 3-(3,4-ジヒドロキシフェニル)アクリル酸
    • 3,4-ジヒドロキシベンゼンアクリル酸
    • カフェー酸
    • 3,4-ジヒドロキシけい皮酸
    • コーヒー酸
    • trans-カフェー酸
    • (E)-3-[3,4-ジヒドロキシフェニル]アクリル酸
    • (E)-3-(3,4-ジヒドロキシフェニル)アクリル酸
    • (E)-3,4-ジヒドロキシけい皮酸
    • (E)-3-(3,4-ジヒドロキシフェニル)プロペン酸
    • 3-(3,4-ジヒドロキシフェニル)-2-プロペン酸
    • カフェ酸
    • 3,4‐ジヒドロキシけい皮酸
    • カフェ酸標準品
    • カフェー酸 (AHP VERIFIED)
    • 抗酸化剤
    • 生化學
    • 阻害剤
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