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    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド

    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド 化學構造式
    50-37-3
    CAS番號.
    50-37-3
    化學名:
    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド
    別名:
    (+)-9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボキサミド;D-リセルグ酸ジエチルアミド;9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド;リセルグ酸ジエチルアミド-25;N,N-ジエチルリセルガミド;リゼルギン酸ジエチルアミド;リセルグ酸ジエチルアミド;デリシド;リセルギド;N,N-ジエチルリセルグアミド
    英語化學名:
    LSD
    英語別名:
    LSA;LSD;Cubes;D-LSD;Ergine;LSD 25;lsd-25;C07542;Delysid;DNAS1L3
    CBNumber:
    CB7418655
    化學式:
    C20H25N3O
    分子量:
    323.44
    MOL File:
    50-37-3.mol

    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド 物理性質

    融點 :
    91-93?C
    比旋光度 :
    D20 +17° (c = 0.5 in pyridine)
    沸點 :
    461.9°C (rough estimate)
    比重(密度) :
    1.1021 (rough estimate)
    屈折率 :
    1.6200 (estimate)
    閃點 :
    2℃
    貯蔵溫度 :
    −20°C
    酸解離定數(Pka):
    pKa 7.5 (Uncertain)
    安定性::
    Stable. Incompatible with strong oxidizing agents.
    EPAの化學物質情報:
    Lysergide (50-37-3)
    安全性情報
    • リスクと安全性に関する聲明
    • 危険有害性情報のコード(GHS)
    主な危険性  T+,T,F,Xn
    Rフレーズ  26/27/28-40-36/38-23/25-36-20/21/22-11
    Sフレーズ  22-28-36-45-33-24-16-7-36/37-26
    RIDADR  UN 2811 6.1/PG 1
    WGK Germany  3
    RTECS 番號 KE4100000
    有毒物質データの 50-37-3(Hazardous Substances Data)
    毒性 LD50 in mice, rats, rabbits (mg/kg): 46, 16.5, 0.3 i.v.
    絵表示(GHS)
    注意喚起語 Danger
    危険有害性情報
    コード 危険有害性情報 危険有害性クラス 區分 注意喚起語 シンボル P コード
    H225 引火性の高い液體および蒸気 引火性液體 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
    H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
    H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
    注意書き
    P210 熱/火花/裸火/高溫のもののような著火源から遠ざ けること。-禁煙。
    P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
    P337+P313 眼の刺激が続く場合:醫師の診斷/手當てを受けること。
    P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。
    P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。

    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド 価格

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入

    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド 化學特性,用途語,生産方法

    解説

    C20H25N3O(323.43).略稱LSD.リセルグ酸とトリフルオロ酢酸の無水物にジエチルアミンを反応させると得られる."白色の結晶性粉末.融點80~85 ℃."+17°(ピリジン).現存の幻覚薬中最強の作用を示し,中樞神経機能を変化させて,幻覚妄想,思考障害,感情の荒廃のような精神異常をもたらす.色彩に富んだ幻視が特徴で,時間と空間の感覚が障害される.また,セロトニン受容體に選択的なきっ抗作用を示す.わが國では麻薬取締法で規制されている.有効量は100 μg 程度.LD50 0.3 mg/kg(ウサギ,靜注).[CAS 50-37-3]
    森北出版「化學辭典(第2版)

    説明

    Lysergic acid diethylamide (LSD) is synthetically derived from the fungus, Claviceps purpuria. Several isomers of this compound exist, although only the D-isomer is considered active. LSD was first synthesized by Albert Hofmann in 1938 in a search for an analeptic drug. After finding its psychogenic activity, it was marketed by Sandoz laboratories under the name Delysid?. It was also reportedly used by the Central Intelligence Agency as a tool for interrogation. Due to its potential for ‘bad trips,’ ‘flashbacks,’ and potential risk for brain injury, LSD was banned federally in 1966 and is currently only used illicitly. LSD is chemically similar to other naturally occurring lysergamides found in multiple species of morning glory.

    化學的特性

    crystalline solid

    使用

    Labelled Lysergide (L488010)

    使用

    Potent hallucinogen; non-selective serotonin receptor agonist. Has been used experimentally as adjunct in study and treatment of mental disorders. Controlled substance.

    使用

    LSD is obtained by partial synthesis fromD-lysergic acid. It is also produced bymicrobial reaction of Claviceps paspali overthe hydroxylethylamide. It is a well-knownhallucinogen and a drug of abuse, listed asa controlled substance in the U.S. Code ofFederal Regulations (Title 21, Part 1308.11,1987). It is used as an antagonist to serotoninand in the study and treatment of mentaldisorders.

    定義

    ChEBI: An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.

    一般的な説明

    Prismatic crystals (from benzene). Tasteless and odorless. A hallucinogen.

    反応プロフィール

    An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

    健康ハザード

    LSD is a strong psychedelic agent. Theeffects in human are excitement, euphoria,hallucinations, and distorted perceptions.It alters the thinking process, producingillusions and loss of contact with reality.In humans, a dose (intramuscular)of 0.7–0.9 mg/kg or an oral dose of2.5–3.0 mg/kg may produce the effectsabove. Other symptoms may include nausea,vomiting, dilation of pupils, restlessness, andperipheral vascoconstriction. However, thereis no reported case of overdose death. In rabbits,somnolence, ataxia, and an increase inbody temperature were the symptoms notedat the LD50 (intravenous) doses at 0.3 mg/kg.
    LD50 value, intravenous (mice): 46 mg/kg
    LD50 value, subcutaneous (guinea pigs):16 mg/kg.

    火災危険

    Flash point data for LSD are not available; however LSD is probably combustible.

    安全性プロファイル

    Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Mutation data reported. Human systemic effects by ingestion and intramuscular routes: euphoria, hallucinations, distorted perceptions, excitement, anorexia, nausea and vomiting. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A much-abused hallucinogen. A federally regulated substance. When heated to decomposition it emits toxic fumes of NOx

    環境運命予測

    LSD may exist in the air or soil. In the air, LSD may be susceptible to photochemical reactions with subsequently induced radical analogs. Photolysis and oxidative degradation may occur with an airborne half-life of 18 min. LSD’s pKa of 7.8 will have a meaningful percentage of the drug in the cationic form allowing it to interact with soil.

    Toxicity evaluation

    LSD’s mechanism of action is not completely understood. LSD’s hallucinogenic effects are secondary to its ability to increase central serotonin activity. LSD also stimulates both D1 and D2 dopamine receptors.

    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド 上流と下流の製品情報

    原材料

    準備製品


    9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド 生産企業

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    50-37-3(9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド)キーワード:


    • 50-37-3
    • 10-didehydro-n,n-diethyl-6-methyl-(8beta)-ergoline-8-carboxamid
    • 9,10-didehydro-n,n-diethyl-6-methyl-ergoline-8-beta-carboxamid
    • 9,10-didehydro-n,n-diethyl-6-methyl-ergoline-8beta-carboxamid
    • 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-beta-carboxamide
    • Cubes
    • Delysid
    • Dextrolysergic Acid diethylamide
    • Diethylamid kyseliny lysergove
    • diethylamidkyselinylysergove
    • D-LSD-25
    • d-Lysergic acid dethylamide
    • D-Lysergic acid diethylamide
    • D-Lysergic acid N,N-diethylamide
    • d-lysergicaciddiethylamide
    • Ergine
    • Ergoline-8beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-
    • Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)-
    • Heavenly blue
    • heavenlyblue
    • Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv.
    • LSA
    • LSD (Alkaloid)
    • LSD 25
    • lsd[alkaloid]
    • lsd-25
    • Lysergamid
    • Lysergamide
    • Lysergamide, N,N-diethyl-
    • Lysergaure diethylamid
    • lysergaurediethylamid
    • (+)-9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボキサミド
    • D-リセルグ酸ジエチルアミド
    • 9,10-ジデヒドロ-N,N-ジエチル-6-メチルエルゴリン-8β-カルボアミド
    • リセルグ酸ジエチルアミド-25
    • N,N-ジエチルリセルガミド
    • リゼルギン酸ジエチルアミド
    • リセルグ酸ジエチルアミド
    • デリシド
    • リセルギド
    • N,N-ジエチルリセルグアミド
    • セロトニン拮抗薬
    • セロトニン作動薬
    • 幻覚薬
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