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    ポリ(アクリル酸メチル),トルエン溶液

    ポリ(アクリル酸メチル),トルエン溶液 化學構造式
    9003-21-8
    CAS番號.
    9003-21-8
    化學名:
    ポリ(アクリル酸メチル),トルエン溶液
    別名:
    ポリ(アクリル酸メチル),トルエン溶液;ポリアクリル酸メチル;ポリ(アクリル酸メチル) 溶液
    英語化學名:
    POLY(METHYL ACRYLATE)
    英語別名:
    Polymethacrylates;POLY(METHYL ACRYLATE);Poly(methyleacrylate);METHYL ACRYLATE LATEX;METHYL ACRYLATE RESIN;Methylacrylatehomopolymer;Polymethyl-acrylate paste;Microparticles based on PMAA;Polymethyl methacrylate,color;poly(methyl acrylate) solution
    CBNumber:
    CB8195335
    化學式:
    C4H6O2
    分子量:
    86.09
    MOL File:
    9003-21-8.mol

    ポリ(アクリル酸メチル),トルエン溶液 物理性質

    沸點 :
    110 °C
    比重(密度) :
    1.22 g/mL at 25 °C
    蒸気密度:
    >1 (vs air)
    屈折率 :
    n20/D 1.494
    閃點 :
    40 °F
    貯蔵溫度 :
    Flammables area
    外見 :
    Liquid
    色:
    Clear
    EPAの化學物質情報:
    2-Propenoic acid, methyl ester, homopolymer (9003-21-8)
    安全性情報
    • リスクと安全性に関する聲明
    • 危険有害性情報のコード(GHS)
    主な危険性  F,Xn
    Rフレーズ  11-38-48/20-63-65-67
    Sフレーズ  36/37-46-62-16
    RIDADR  UN 1294 3/PG 2
    WGK Germany  2
    自然発火溫度 ~896 °F
    HSコード  32082010
    消防法 危-4-1-II
    安衛法 有機溶剤中毒予防規則:第2種有機溶剤,57,57-2
    PRTR法 1-300
    絵表示(GHS)
    注意喚起語 Danger
    危険有害性情報
    コード 危険有害性情報 危険有害性クラス 區分 注意喚起語 シンボル P コード
    H225 引火性の高い液體および蒸気 引火性液體 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
    H304 飲み込んで気道に侵入すると生命に危険のおそ れ 吸引性呼吸器有害性 1 危険
    H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
    H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
    H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
    注意書き
    P210 熱/火花/裸火/高溫のもののような著火源から遠ざ けること。-禁煙。
    P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
    P281 指定された個人用保護具を使用すること。
    P301+P310 飲み込んだ場合:直ちに醫師に連絡すること。
    P331 無理に吐かせないこと。

    ポリ(アクリル酸メチル),トルエン溶液 価格 もっと(3)

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
    関東化學株式會社(KANTO) 31069-1A ポリ(アクリル酸メチル),トルエン溶液
    Poly(methyl acrylate), in toluene
    9003-21-8 500mg ¥13700 2021-03-23 購入
    Sigma-Aldrich Japan 182214 ポリ(アクリル酸メチル) 溶液 average Mw ~40,000 by GPC
    Poly(methyl acrylate) solution average Mw ~40,000 by GPC
    9003-21-8 50g ¥28900 2021-03-23 購入
    Sigma-Aldrich Japan 182214 ポリ(アクリル酸メチル) 溶液 average Mw ~40,000 by GPC
    Poly(methyl acrylate) solution average Mw ~40,000 by GPC
    9003-21-8 100g ¥53100 2021-03-23 購入

    ポリ(アクリル酸メチル),トルエン溶液 化學特性,用途語,生産方法

    定義

    本品は、アクリル酸メチルの重合體であり、次の化學式で表される。

    解説

    略稱PMA.アクリル酸メチルを溶液重合,または乳化重合で得られる無色の無定形固體.ベンゼン,アセトン,酢酸エチルなどに可溶,エーテルには膨潤し,四塩化炭素や飽和炭化水素,アルコール類などに不溶.軟化點75 ℃,ガラス転移點3 ℃.300 ℃ 以上で分解する.アルカリによって加水分解する.ヒドラジンと反応し,種々の誘導體の原料になるほか,接著剤,塗料用に広く用いられる.繊維加工方面では補強,織物のり剤,不織布,バインダー用として利用され,紙加工や,合成ゴム,皮革加工にも用いられる.[CAS 9003-21-8]
    森北出版「化學辭典(第2版)

    化粧品の成分用途

    皮膜形成剤

    化學的特性

    Polymethacrylates are synthetic cationic and anionic polymers of dimethylaminoethyl methacrylates, methacrylic acid, and methacrylic acid esters in varying ratios. Several different types are commercially available and may be obtained as the dry powder, as an aqueous dispersion, or as an organic solution. A (60 : 40) mixture of acetone and propan-2-ol is most commonly used as the organic solvent.
    Eudragit E is a cationic polymer based on dimethylaminoethyl methacrylate and other neutral methacrylic acid esters. It is soluble in gastric fluid as well as in weakly acidic buffer solutions (up to pH≈5). Eudragit E is available as a 12.5% ready-to-use solution in propan-2-ol–acetone (60 : 40). It is light yellow in color with the characteristic odor of the solvents. Solvent-free granules contain ≈98% dried weight content of Eudragit E. Eudragit E PO is a white free-flowing powder with at least 95% of dry polymer.
    Eudragit L and S, also referred to as methacrylic acid copolymers in the USP32–NF27 monograph, are anionic copolymerization products of methacrylic acid and methyl methacrylate. The ratio of free carboxyl groups to the ester is approximately 1 : 1 in Eudragit L (Type A) and approximately 1 : 2 in Eudragit S (Type B). Both polymers are readily soluble in neutral to weakly alkaline conditions (pH 6–7) and form salts with alkalis, thus affording film coats that are resistant to gastric media but soluble in intestinal fluid. They are available as a 12.5% solution in propan-2-ol without plasticizer (Eudragit L 12.5 and S 12.5); and as a 12.5% ready-to-use solution in propan-2-ol with 1.25% dibutyl phthalate as plasticizer (Eudragit L 12.5 P and S 12.5 P). Solutions are colorless, with the characteristic odor of the solvent. Eudragit L - 100 and Eudragit S-100 are white free-flowing powders with at least 95% of dry polymers.
    Eudragit FS 30 D is the aqueous dispersion of an anionic copolymer based on methyl acrylate, methyl methacrylate, and methacrylic acid. The ratio of free carboxyl groups to ester groups is approximately 1 : 10. It is a highly flexible polymer, designed for use in enteric-coated solid-dosage forms, and dissolves in aqueous systems at pH >7.
    Eudragit RL and Eudragit RS, also referred to as ammonio methacrylate copolymers in the USP32–NF27 monograph, are copolymers synthesized from acrylic acid and methacrylic acid esters, with Eudragit RL (Type A) having 10% of functional quaternary ammonium groups and Eudragit RS (Type B) having 5% of functional quaternary ammonium groups. The ammonium groups are present as salts and give rise to pH-independent permeability of the polymers. Both polymers are water-insoluble, and films prepared from Eudragit RL are freely permeable to water, whereas, films prepared from Eudragit RS are only slightly permeable to water. They are available as 12.5% ready-to-use solutions in propan-2-ol–acetone (60 : 40). Solutions are colorless or slightly yellow in color, and may be clear or slightly turbid; they have an odor characteristic of the solvents. Solvent-free granules (Eudragit RL 100 and Eudragit RS 100) contain 597% of the dried weight content of the polymer.
    Eudragit RL PO and Eudragit RS PO are fine, white powders with a slight amine-like odor. They are characteristically the same polymers as Eudragit RL and RS. They contain 597% of dry polymer.
    Eudragit RL 30 D and Eudragit RS 30 D are aqueous dispersions of copolymers of acrylic acid and methacrylic acid esters with a low content of quaternary ammonium groups. The dispersions contain 30% polymer. The quaternary groups occur as salts and are responsible for the permeability of films made from these polymers. Films prepared from Eudragit RL 30 D are readily permeable to water and to dissolved active substances, whereas films prepared from Eudragit RS 30 D are less permeable to water. Film coatings prepared from both polymers give pH-independent release of active substance. Plasticizers are usually added to improve film properties.
    Eudragit NE 30 D and Eudragit NE 40 D are aqueous dispersions of a neutral copolymer consisting of polymethacrylic acid esters. The dispersions are milky-white liquids of low viscosity and have a weak aromatic odor. Films prepared from the lacquer swell in water, to which they become permeable. Thus, films produced are insoluble in water, but give pH-independent drug release.
    Eudragit NM 30 D is an aqueous dispersion of a neutral copolymer based on ethyl acrylate and methyl methacrylate, and is of identical monomer composition to Eudragit NE 30 D.
    Eudragit L 30 D-55 is an aqueous dispersion of an anionic copolymer based on methacrylic acid and ethyl acrylate. The copolymer corresponds to USP32–NF27 methacrylic acid copolymer, Type C. The ratio of free-carboxyl groups to ester groups is 1 : 1. Films prepared from the copolymers dissolve above pH 5.5, forming salts with alkalis, thus affording coatings that are insoluble in gastric media but soluble in the small intestine.
    Eastacryl 30D and Kollicoat MAE 30 DP are also aqueous dispersions of the anionic copolymer based on methacrylic acid and ethyl acrylate. The copolymer also corresponds to USP32–NF27 methacrylic acid copolymer, Type C. The ratio of free-carboxyl groups to ester groups is 1 : 1. Films prepared from the copolymers dissolve above pH 5.5, forming salts with alkalis, thus affording coatings that are insoluble in gastric media but soluble in the small intestine.
    Eudragit L 100-55 (prepared by spray-drying Eudragit L 30 D- 55) is a white, free-flowing powder that is redispersible in water to form a latex that has properties similar to those of Eudragit L 30 D- 55.
    Acryl-EZE and Acryl-EZE MP are also commercially available as redispersible powder forms, which are designed for enteric coating of tablets and beads, respectively.

    化學的特性

    clear liquid

    使用

    PMA/methylamine borane (MeAB) composites, prepared by solution blending process finds uses as a hydrogen storage material with better dehydrogenation property compared to MeAB.

    調製方法

    Prepared by the polymerization of acrylic and methacrylic acids or their esters, e.g. butyl ester or dimethylaminoethyl ester

    製造方法

    The structure of methyl acrylate is H2C=CH-COOCH3. The monomer used to prepare poly(methyl acrylate) is produced by the oxidation of propylene. The resin is made by free-radical polymerization initiated by peroxide catalysts and has the following formula:
    Poly(methyl acrylate)  structure
    Poly(methyl acrylate) resins vary from soft, elastic, film-forming materials to hard plastics.

    定義

    ChEBI: An acrylate macromolecule composed of repeating methoxycarbonylethylene units.

    応用例(製薬)

    Polymethacrylates are primarily used in oral capsule and tablet formulations as film-coating agents.(1–21) Depending on the type of polymer used, films of different solubility characteristics can be produced;
    Eudragit E is used as a plain or insulating film former. It is soluble in gastric fluid below pH 5. In contrast, Eudragit L, S and FS types are used as enteric coating agents because they are resistant to gastric fluid. Different types of enteric coatings are soluble at different pH values: e.g. Eudragit L is soluble at pH > 6 whereas Eudragit S and FS are soluble at pH > 7. The S grade is generally used for coating tablets, while the flexible FS 30 D dispersion is preferred for coating particles.
    Eudragit RL, RS, NE 30D, NE 40D, andNM30D are used to form water-insoluble film coats for sustained-release products. Eudragit RL films are more permeable than those of Eudragit RS, and films of varying permeability can be obtained by mixing the two types together. The neutral Eudragit NE/NM grades do not have functional ionic groups. They swell in aqueous media independently of pH without dissolving.
    Eudragit L 30 D-55 is used as an enteric coating film former for solid-dosage forms. The coating is resistant to gastric juice but dissolves readily at above pH 5.5.
    Eudragit L 100-55 is an alternative to Eudragit L 30 D-55. It is commercially available as a redispersible powder.
    Kollicoat MAE 100 P, Acryl-EZE and Acryl-EZE MP are also commercially available as redispersible powder forms, which are designed for enteric coating of tablets or beads.
    Eastacryl 30 D and Kollicoat MAE 30 DP are aqueous dispersions of methacrylic acid–ethyl acrylate copolymers. They are also used as enteric coatings for solid-dosage forms. Polymethacrylates are also used as binders in both aqueous and organic wet-granulation processes. Larger quantities (5–20%) of dry polymer are used to control the release of an active substance from a tablet matrix. Solid polymers may be used in directcompression processes in quantities of 10–50%.
    Polymethacrylate polymers may additionally be used to form the matrix layers of transdermal delivery systems and have also been used to prepare novel gel formulations for rectal administration.

    安全性

    Polymethacrylate copolymers are widely used as film-coating materials in oral pharmaceutical formulations. They are also used in topical formulations and are generally regarded as nontoxic and nonirritant materials.
    Based on relevant chronic oral toxicity studies in rats and conventionally calculated with a safety factor of 100, a daily intake of 2–200 mg/kg body-weight depending on the grade of Eudragit may be regarded as essentially safe in humans.

    貯蔵

    Dry powder polymer forms are stable at temperatures less than 30°C. Above this temperature, powders tend to form clumps, although this does not affect the quality of the substance and the clumps can be readily broken up. Dry powders are stable for at least 3 years if stored in a tightly closed container at less than 30°C.
    Dispersions are sensitive to extreme temperatures and phase separation occurs below 0°C. Dispersions should therefore be stored at temperatures between 5 and 25°C and are stable for at least 18 months after shipping from the manufacturer’s warehouse if stored in a tightly closed container at the above conditions.

    純化方法

    Precipitate it from a 2% solution in acetone by addition of water.

    不和合性

    Incompatibilities occur with certain polymethacrylate dispersions depending upon the ionic and physical properties of the polymer and solvent. For example, coagulation may be caused by soluble electrolytes, pH changes, some organic solvents, and extremes of temperature. For example, dispersions of Eudragit L 30 D, RL 30 D, L 100-55, and RS 30 D are incompatible with magnesium stearate. Eastacryl 30 D, Kollicoat MAE 100 P, and Kollicoat MAE 30 DP are also incompatible with magnesium stearate.
    Interactions between polymethacrylates and some drugs can occur, although solid polymethacrylates and organic solutions are generally more compatible than aqueous dispersions.

    規制狀況(Regulatory Status)

    Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

    ポリ(アクリル酸メチル),トルエン溶液 上流と下流の製品情報

    原材料

    準備製品


    ポリ(アクリル酸メチル),トルエン溶液 生産企業

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    9003-21-8(ポリ(アクリル酸メチル),トルエン溶液)キーワード:


    • 9003-21-8
    • 2-Propenoicacid,methylester,homopolymer
    • Poly(methyl acrylate) solution average Mw ~40,000 by GPC
    • Poly(methyleacrylate)
    • poly(methyl acrylate) macromolecule
    • Methyl 2-propenoate homopolymer
    • Microparticles based on PMAA
    • Microparticles based on poly(methacrylic acid)
    • Poly(methyl acrylate), solution in toluene
    • Methylacrylatehomopolymer
    • Polymethacrylates
    • POLY(METHYL ACRYLATE)
    • METHYL ACRYLATE LATEX
    • METHYL ACRYLATE RESIN
    • Polymethyl-acrylate paste
    • POLY(METHYL ACRYLATE), SOLUTION IN TOLUE NE, AVERAGE MW CA. 40,000 (GPC
    • POLY(METHYL ACRYLATE), SECONDARY STANDAR D (TOLUENE)
    • solutionintolueneaveragemwca.40000(gpc)
    • poly(methyl acrylate) solution
    • Polymethyl methacrylate,industrial grade
    • Polymethyl methacrylate,color
    • Polymethyl methacrylate,aero grade
    • POLY(METHYL ACRYLATE) ISO 9001:2015 REACH
    • ポリ(アクリル酸メチル),トルエン溶液
    • ポリアクリル酸メチル
    • ポリ(アクリル酸メチル) 溶液
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