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    安息香酸 ベンジル

    安息香酸  ベンジル 化學構造式
    120-51-4
    CAS番號.
    120-51-4
    化學名:
    安息香酸 ベンジル
    別名:
    安息香酸 ベンジル;ジラート;ベンゾナート;スカバンカ;ベンゼンカルボン酸ベンジル;バンゾアート;ペルスカビン;ベンジル=ベンゾアート;ノボスカビン;ベニラート;コレベンズ;アスカビオール;ベンジレツ;安息香酸フェニルメチル;バンゾエイト;安息香酸ベンジル;アスカビン;ベンジルベンゾエ-ト;ベンゾエート 安息香酸ベンジル;ベンジル=ベンゾアート (BENZYL BENZOATE)
    英語化學名:
    Benzyl benzoate
    英語別名:
    BJSBZ;Zylate;ASCABIN;Scabide;Benylate;ASCABIOL;Colebenz;Scabagen;Scabanca;Scabitox
    CBNumber:
    CB9152283
    化學式:
    C14H12O2
    分子量:
    212.24
    MOL File:
    120-51-4.mol

    安息香酸 ベンジル 物理性質

    融點 :
    17-20 °C (lit.)
    沸點 :
    323-324 °C (lit.)
    比重(密度) :
    1.118 g/mL at 20 °C (lit.)
    蒸気圧:
    1 mm Hg ( 125 °C)
    屈折率 :
    n20/D 1.568(lit.)
    FEMA :
    2138 | BENZYL BENZOATE
    FEMA :
    2797 | OCTANAL
    閃點 :
    298 °F
    貯蔵溫度 :
    2-8°C
    溶解性:
    Miscible with ethanol, alcohol, chloroform, ether, oils.
    外見 :
    Liquid
    色:
    Clear colorless
    水溶解度 :
    practically insoluble
    JECFA Number:
    24
    Merck :
    14,1127
    BRN :
    2049280
    安定性::
    Stable. Substances to be avoided include strong oxidizing agents. Combustible.
    InChIKey:
    SESFRYSPDFLNCH-UHFFFAOYSA-N
    CAS データベース:
    120-51-4(CAS DataBase Reference)
    NISTの化學物質情報:
    Benzyl Benzoate(120-51-4)
    EPAの化學物質情報:
    Benzyl benzoate (120-51-4)
    安全性情報
    • リスクと安全性に関する聲明
    • 危険有害性情報のコード(GHS)
    主な危険性  Xn,N
    Rフレーズ  22-51/53
    Sフレーズ  25-61-46
    RIDADR  UN 3082 9 / PGIII
    WGK Germany  2
    RTECS 番號 DG4200000
    自然発火溫度 896 °F
    TSCA  Yes
    國連危険物分類  9
    HSコード  29163100
    有毒物質データの 120-51-4(Hazardous Substances Data)
    毒性 LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)
    消防法 危険物第4類第三石油類(非水溶性)
    化審法 (3)-1389 優先評価化學物質
    絵表示(GHS)
    注意喚起語 Warning
    危険有害性情報
    コード 危険有害性情報 危険有害性クラス 區分 注意喚起語 シンボル P コード
    H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
    H401 水生生物に毒性 水生環境有害性、急性毒性 2 P273, P501
    H411 長期的影響により水生生物に毒性 水生環境有害性、慢性毒性 2
    注意書き
    P264 取扱い後は皮膚をよく洗うこと。
    P264 取扱い後は手や顔をよく洗うこと。
    P270 この製品を使用する時に、飲食または喫煙をしないこ と。
    P273 環境への放出を避けること。
    P330 口をすすぐこと。
    P501 內容物/容器を...に廃棄すること。

    安息香酸 ベンジル 価格 もっと(58)

    メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
    富士フイルム和光純薬株式會社(wako) W01ACSALR-019S-ET-10X 安息香酸ベンジル
    Benzyl benzoate, 1000 ug/mL in Ethanol
    120-51-4 1mL ¥7400 2021-03-23 購入
    富士フイルム和光純薬株式會社(wako) W01ACSALR-019N 安息香酸ベンジル
    Benzyl benzoate
    120-51-4 100mg ¥7400 2021-03-23 購入
    東京化成工業 B0064 安息香酸ベンジル >99.0%(GC)
    Benzyl Benzoate >99.0%(GC)
    120-51-4 25g ¥1600 2021-03-23 購入
    東京化成工業 B0064 安息香酸ベンジル >99.0%(GC)
    Benzyl Benzoate >99.0%(GC)
    120-51-4 500g ¥3800 2021-03-23 購入
    関東化學株式會社(KANTO) 10586-1A 安息香酸ベンジル
    Benzyl benzoate
    120-51-4 1L ¥10000 2021-03-23 購入

    安息香酸 ベンジル MSDS


    Benzyl benzoate

    安息香酸 ベンジル 化學特性,用途語,生産方法

    外観

    無色~わずかにうすい黃色, 澄明の液體

    定義

    本品は、安息香酸(*)とベンジルアルコール(*)とのエステルであり、次の化學式で表される。
    參照表示名稱:安息香酸, ベンジルアルコール

    溶解性

    水に不溶, エタノール, エーテルに易溶。エタノール及びジエチルエーテルに極めて溶けやすく、水にはほとんど溶けない。

    用途

    香料材料(保留剤、溶剤)、可塑剤、醫薬原料、有機合成原料。

    化粧品の成分用途

    忌避剤.殺蟲剤、溶剤、香料

    効能

    外寄生生物駆除薬

    説明

    Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.

    化學的特性

    Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor.
    Benzyl Benzoate
    Benzyl Benzoate is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.

    天然物の起源

    Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).

    使用

    Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies , for example as a combination drug of benzyl benzoate/disulfiram.
    It has other uses :
    a fixative in fragrances to improve the stability and other characteristics of the main ingredients
    a food additive in artificial flavors
    a plasticizer in cellulose and other polymers
    a solvent for various chemical reactions
    a treatment for sweet itch in horses
    a treatment for scaly leg mites in chickens.

    使用

    As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.

    使用

    benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.

    調製方法

    BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavors, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).

    適応癥

    Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only a veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
    Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.

    製造方法

    By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.

    brand name

    Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop).

    Taste threshold values

    Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.

    Synthesis Reference(s)

    Journal of Heterocyclic Chemistry, 24, p. 187, 1987 DOI: 10.1002/jhet.5570240135
    Tetrahedron Letters, 27, p. 2383, 1986 DOI: 10.1016/S0040-4039(00)84535-9

    一般的な説明

    Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma component of cranberry, mango and Egyptian Jasminum sambac flowers.

    危険性

    Irritant to eyes, skin.

    応用例(製薬)

    Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
    However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
    Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.

    接觸アレルゲン

    Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.

    Biochem/physiol Actions

    Benzyl benzoate is the condensation product of benzoic acid and benzyl alcohol. It is utilized for treating human scabies as well as kills house dust mite.

    臨床応用

    Benzyl benzoate is a naturally occurring ester obtained fromPeru balsam and other resins. It is also prepared syntheticallyfrom benzyl alcohol and benzoyl chloride. The ester isa clear colorless liquid with a faint aromatic odor. It is insolublein water but soluble in organic solvents.
    Benzyl benzoate is an effective scabicide when appliedtopically. Immediate relief from itching probably resultsfrom a local anesthetic effect; however, a complete cureis frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized withtriethanolamine. This preparation has the additionaladvantage of being essentially odorless, nonstaining, andnonirritating to the skin. It is applied topically as a lotionover the entire dampened body, except the face.

    安全性

    Benzyl benzoate is metabolized by rapid hydrolysis to benzoic acid and benzyl alcohol. Benzyl alcohol is then further metabolized to hippuric acid, which is excreted in the urine.
    Benzyl benzoate is widely used as a 25% v/v topical application in the treatment of scabies and as an excipient in intramuscular injections and oral products. Adverse reactions to benzyl benzoate include skin irritation and hypersensitivity reactions. Oral ingestion may cause harmful stimulation of the CNS and convulsions. Benzyl benzoate should be avoided by perople with perfume allergy.
    LD50 (cat, oral): 2.24 g/kg
    LD50 (dog, oral): 22.44 g/kg
    LD50 (guinea pig, oral): 1.0 g/kg
    LD50 (mouse, oral): 1.4 g/kg
    LD50 (rabbit, oral): 1.68 g/kg
    LD50 (rabbit, skin): 4.0 g/kg
    LD50 (rat, oral): 0.5 g/kg
    LD50 (rat, skin): 4.0 g/kg

    Chemical Synthesis

    This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.

    環境運命予測

    Benzyl benzoate acts as a local irritant. At high levels of exposure, free benzoic acid may sequester significant amounts of acetyl coenzyme A (CoA), which could disrupt cholinergic signaling. Recent findings suggest that benzyl benzoate may have estrogenic properties.

    代謝

    Benzyl benzoate, a relatively non-toxic liquid widely used for the treatment of scabies, is converted into benzoic acid in vivo (Williams, 1959).

    貯蔵

    Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided.

    Toxicity evaluation

    Acute oral LD50 for rats: 1,700 mg/kg

    不和合性

    Benzyl benzoate is incompatible with alkalis and oxidizing agents.

    規制狀況(Regulatory Status)

    Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

    安息香酸 ベンジル 上流と下流の製品情報

    原材料

    準備製品


    安息香酸 ベンジル 生産企業

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    120-51-4(安息香酸 ベンジル)キーワード:


    • 120-51-4
    • Benzyl benzoate ReagentPlus(R), >=99.0%
    • Benzyl benzoate Vetec(TM) reagent grade, 98%
    • Benzoic acid benzyl ester≥ 99% (GC)
    • VANZOATE(R)
    • VENZONATE(R)
    • Benylate
    • Benzyl alcohol benzoic ester
    • Benzyl ester
    • benzylalcoholbenzoicester
    • Benzylester kyseliny benzoove
    • ASCABIN
    • ASCABIOL
    • ASCABIOL(R)
    • BENZOATO DE BENCILO
    • Benzyl benzoate 99+ %
    • Phenylmethyl benzoate
    • BENZYL BENZOATE, 1GM, NEAT
    • BENZYL BENZOATE 99+% FCC
    • BENZYL BENZOATE 99+% NATURAL FCC
    • BENZYL BENZOATE, USP
    • BENZYL BENZOATE, PH EUR
    • Benzyl Benzoate PQ
    • BENZYL BENZOATE, PHARMA
    • benzylbenzoate,phenylmethylbenzoate
    • Benzylbenzoat
    • Benzyl Benoate
    • Benryl benzoate
    • spasmodin
    • Benzile benzoate
    • BENZYL BENZOATE, NATURAL
    • 安息香酸 ベンジル
    • ジラート
    • ベンゾナート
    • スカバンカ
    • ベンゼンカルボン酸ベンジル
    • バンゾアート
    • ペルスカビン
    • ベンジル=ベンゾアート
    • ノボスカビン
    • ベニラート
    • コレベンズ
    • アスカビオール
    • ベンジレツ
    • 安息香酸フェニルメチル
    • バンゾエイト
    • 安息香酸ベンジル
    • アスカビン
    • ベンジルベンゾエ-ト
    • ベンゾエート 安息香酸ベンジル
    • ベンジル=ベンゾアート (BENZYL BENZOATE)
    • 安息香酸ベンジル, 99+%
    • 安息香酸ベンジル STANDARD
    • 安息香酸ベンジル Standard, 5.0 mg/mL in Hexane
    • 安息香酸ベンジル, 1000 μg/mL in Ethanol
    • 安息香酸ベンジル, 5.0 mg/mL in Hexane
    • 安息香酸ベンジル (JP17)
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