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    ?????

    ?????
    ????? ??? ???
    ?? ??:
    99-76-3
    ???:
    ?????
    ???(??):
    p-??????????;?????;4-???????,??????;4-????????????????;p-????????;P-???????,??????;??P-???????;??P-?????????;?????????????;???????;4-???????????;?????
    ???:
    Methylparaben
    ???(??):
    Abiol;Moldex;Septos;NIPAGIN;Nigagin;Paraben;Paridol;Solbrol;metaben;Maseptol
    CBNumber:
    CB0184566
    ???:
    C8H8O3
    ??? ??:
    152.15
    MOL ??:
    99-76-3.mol

    ????? ??

    ???
    125-128 °C (lit.)
    ?? ?
    298.6 °C
    ??
    1,46g/cm
    ???
    0.000005 hPa (20 °C)
    FEMA
    2710 | METHYL P-HYDROXYBENZOATE
    ???
    1.4447 (estimate)
    ???
    280°C
    ?? ??
    room temp
    ???
    ethanol: soluble0.1M, clear, colorless
    ?? ?? (pKa)
    pKa 8.15(H2O,t =20.0) (Uncertain)
    ??? ??
    Crystalline Powder
    ??
    White to almost white
    ??????(pH)
    5.8 (H2O, 20°C) (saturated solution)
    ???
    Slightly soluble in water.
    ???
    131℃
    Merck
    14,6107
    BRN
    509801
    ???
    Stable. Incompatible with strong oxidizing agents, strong bases.
    InChIKey
    LXCFILQKKLGQFO-UHFFFAOYSA-N
    CAS ??????
    99-76-3(CAS DataBase Reference)
    NIST
    Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
    EPA
    Methylparaben (99-76-3)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xi,Xn
    ?? ???? ?? 36/37/38-20/21/22-36
    ????? 26-36-24/25-39
    ????(UN No.) UN 2769
    WGK ?? 1
    RTECS ?? DH2450000
    ?? ?? ?? >600 °C
    TSCA Yes
    HS ?? 29182930
    ?? ?? ??? 99-76-3(Hazardous Substances Data)
    ?? LD50 orally in Rabbit: 2100 mg/kg
    ???? ?? KE-20379
    ????(GHS):
    ?? ?:
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H303 ??? ??? ? ?? ?? ?? ?? - ?? ?? 5 P312
    H412 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 3 P273, P501
    ??????:
    P273 ???? ???? ???.
    NFPA 704
    0
    2 0

    ????? MSDS


    4-Hydroxybenzoic acid methyl ester

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    Methylparaben occurs as colorless crystals or a white crystalline powder. It is odorless or almost odorless and has a slight burning taste. Soluble in alcohol,ether; slightly soluble in water, benzene, and carbontetrachloride.

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    Methyl p-hydroxybenzoate is odorless or has a faint characteristic odor and a slight burning taste. Methyl p-hydroxybenzoate is more commonly known as methyl paraben and is an ester of p-hydroxybenzoic acid.

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    Reported present in cloudberry, yellow passion fruit juice, white wine, botrytised wine and Bourbon vanilla.

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    parabens is one of the most commonly used group of preservatives in the cosmetic, pharmaceutical, and food industries. Parabens provide bacteriostatic and fungistatic activity against a diverse number of organisms, and are considered safe for use in cosmetics, particularly in light of their low sensitizing potential. An evaluation of preservatives for use in leave-on cosmetic preparations lists parabens among the least sensitizing. The range of concentrations used in cosmetics varies between 0.03 and 0.30 percent, depending on the conditions for use and the product to which the paraben is added.
    Methylparaben is one of the most popular preservatives in beauty products and food items. According to the National Library of Medicine, the ingredient occurs naturally in a handful of fruits—like blueberries—though it can also be created synthetically.It's found in everything from cream cleansers and moisturizers to primers and foundations and helps these products maintain their effectiveness. Rabach says that it's chock-full of anti-fungal and antibacterial properties, which work wonders to extend the shelf life of skincare, haircare, and cosmetic products.
    https://www.byrdie.com/methylparaben-for-skin-4779820

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    Methylparaben is an antimicrobial agent which is a white free-flowing powder. it is active against yeast and molds over a wide ph range. see parabens.

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    Methyl 4-hydroxybenzoate is used as an anti-fungal agent. It is also used as a preservative in foods, beverages and cosmetics. It acts as an inhibitor of growth of molds and to lesser extent bacteria and as a vehicle for ophthalmic solution.

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    ChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.

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    Produced by the methanol esterification of p-hydroxybenzoic acid in the presence of sulfuric acid. The materials are heated for distillation in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

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    Methylparaben is prepared by the esterification of p-hydroxybenzoic acid with methanol.

    Aroma threshold values

    Detection: 2.6 ppm.

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    Methyl paraben is basically a methyl ester of p-hydroxybenzoic acid. It is non-toxic, and non-carcinogenic in nature. It is a stable, non-volatile compound and finds application as an anti-microbial preservative in foods, drugs and cosmetics. It is readily absorbed through the skin and gastrointestinal tract. Upon hydrolyzation, it is hydrolyzed to p-hydroxybenzoic acid, and the conjugates formed get rapidly excreted in the urine.

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    Toxic. Use in foods restricted to 0.1%.

    Pharmaceutical Applications

    Methylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations; see Table I. It may be used either alone or in combination with other methylparaben is the most frequently used antimicrobial preservative.
    The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Antimicrobial activity increases as the chain length of the alkyl moiety is increased, but aqueous solubility decreases; therefore a mixture of parabens is frequently used to provide effective preservation. Preservative efficacy is also improved by the addition of propylene glycol (2–5%), or by using parabens in combination with other antimicrobial agents such as imidurea;
    Owing to the poor solubility of the parabens, paraben salts (particularly the sodium salt) are more frequently used in formulations. However, this raises the pH of poorly buffered formulations.
    Methylparaben (0.18%) together with propylparaben (0.02%) has been used for the preservation of various parenteral pharmaceutical formulations;

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    This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

    Biochem/physiol Actions

    Methyl 4-hydroxybenzoate, also called methyl paraben or nipagin, comprises the ester of p-hydroxybenzoic acid. It is present naturally in cloudberry, white wine and bourbon vanilla. Methyl 4-hydroxybenzoate has antimicrobial and antifungal functionality and is commercially used as a preservative in the food, cosmetic and pharmaceutical industry. Methyl 4-hydroxybenzoate has cytotoxic effects on keratinocytes in the presence of sunlight. Methyl 4-hydroxybenzoate upon solar irradiation mediates DNA damage and modulates esterase metabolism resulting in skin damage and favors cancer progression. Methyl 4-hydroxybenzoate has estrogenic functionality and upregulates estrogen-related genes.

    Safety

    Methylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations. Although parabens have also been used as preservatives in injections and ophthalmic preparations, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. These experiences may depend on immune responses to enzymatically formed metabolites of the parabens in the skin.
    Parabens are nonmutagenic, nonteratogenic, and noncarcinogenic. Sensitization to the parabens is rare, and these compounds do not exhibit significant levels of photocontact sensitization or phototoxicity.
    Hypersensitivity reactions to parabens, generally of the delayed type and appearing as contact dermatitis, have been reported. However, given the widespread use of parabens as preservatives, such reactions are relatively uncommon; the classification of overstated. Immediate hypersensitivity reactions following injection of preparations containing parabens have also been reported.
    Delayed-contact dermatitis occurs more frequently when parabens are used topically, but has also been reported to occur after oral administration.
    Unexpectedly, preparations containing parabens may be used by patients who have reacted previously with contact dermatitis provided they are applied to another, unaffected, site. This has been termed the paraben paradox.
    Concern has been expressed over the use of methylparaben in infant parenteral products because bilirubin binding may be affected, which is potentially hazardous in hyperbilirubinemic neonates.
    The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg bodyweight.
    LD50 (dog, oral): 3.0 g/kg
    LD50 (mouse, IP): 0.96 g/kg
    LD50 (mouse, SC): 1.20 g/kg

    Carcinogenicity

    The carcinogenic potential of methyl paraben has been studied in rodents. Several studies are available, but none that expose animals via oral or dermal routes. No evidence of a carcinogenic effect was observed following intravenous or subcutaneous injection .

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    Aqueous solutions of methylparaben at pH 3–6 may be sterilized by autoclaving at 120°C for 20 minutes, without decomposition. Aqueous solutions at pH 3–6 are stable (less than 10% decomposition) for up to about 4 years at room temperature, while aqueous solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days storage at room temperature);
    Methylparaben should be stored in a well-closed container in a cool, dry place.

    Purification Methods

    Fractionally crystallise the ester from its melt, and recrystallise it from *benzene, then from *benzene/MeOH and dry it over CaCl2 in a vacuum desiccator. [Beilstein 10 IV 360.]

    ? ???

    The antimicrobial activity of methylparaben and other parabens is considerably reduced in the presence of nonionic surfactants, such as polysorbate 80, as a result of micellization.However, propylene glycol (10%) has been shown to potentiate the antimicrobial activity of the parabens in the presence of nonionic surfactants and prevents the interaction between methylparaben and polysorbate 80.
    Incompatibilities with other substances, such as bentonite, magnesium trisilicate,talc,tragacanth,sodium alginate, essential oils,sorbitol,and atropine,have been reported. It also reacts with various sugars and related sugar alcohols. Absorption of methylparaben by plastics has also been reported; the amount absorbed is dependent upon the type of plastic and the vehicle. It has been claimed that low-density and high-density polyethylene bottles do not absorb methylparaben.
    Methylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

    Regulatory Status

    Methylparaben and propylparaben are affirmed GRAS Direct Food Substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%.
    Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalation preparations; ophthalmic preparations; oral capsules, tablets, solutions and suspensions; otic, rectal, topical, and vaginal preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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