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    ??? ????? ????

    ??? ????? ????
    ??? ????? ???? ??? ???
    ?? ??:
    77-90-7
    ???:
    ??? ????? ????
    ???(??):
    ?????????????;CitroflexA4,??????-N-??????;???????????;????????????;??????????;???????????;?????????????;??? ????? ?????
    ???:
    Acetyl tributyl citrate
    ???(??):
    ATBC;Blo-trol;Estaflex;FEMA 3080;Uniplex 84;citroflexa;Citroflex A;citroflexa4;Citroflex A 4;acetylbutylcitrate
    CBNumber:
    CB0408022
    ???:
    C20H34O8
    ??? ??:
    402.48
    MOL ??:
    77-90-7.mol

    ??? ????? ???? ??

    ???
    -59 °C
    ?? ?
    327 °C
    ??
    1.05 g/mL at 25 °C (lit.)
    ???
    0.26 psi ( 20 °C)
    ???
    n20/D 1.443(lit.)
    FEMA
    3080 | TRIBUTYL ACETYLCITRATE
    ???
    >230 °F
    ?? ??
    Store below +30°C.
    ???
    Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
    ??? ??
    neat
    ???
    <0.1 g/100 mL
    ???
    -80℃
    JECFA Number
    630
    BRN
    2303316
    InChIKey
    QZCLKYGREBVARF-UHFFFAOYSA-N
    CAS ??????
    77-90-7(CAS DataBase Reference)
    NIST
    1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
    EPA
    Acetyl tributyl citrate (77-90-7)

    ??

    ????? 24/25
    WGK ?? 3
    RTECS ?? TZ8330000
    HS ?? 29181500
    ?? ?? ??? 77-90-7(Hazardous Substances Data)
    ???? ?? KE-00158

    ??? ????? ???? MSDS


    Acetyl tributyl citrate

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    clear colorless liquid

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    Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

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    Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

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    Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

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    These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

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    Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

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    plasticizer flavoring agent

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    Aqueous-based pharmaceutical coat- ings.

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    From citric acid via the tributyl ester followed by acetylation.

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    Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

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    Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
    Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

    Pharmaceutical Applications

    Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

    Safety Profile

    When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

    Safety

    and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
    LD50 (cat, oral): >50 mL/kg
    LD50 (mouse, IP): >4 g/kg
    LD50 (rat, oral): >31.5 g/kg

    Carcinogenicity

    The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

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    Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

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    Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

    Regulatory Status

    Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

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