• ChemicalBook
    Chinese English Japanese Germany Korea

    ?????

    ?????
    ????? ??? ???
    ?? ??:
    1197-18-8
    ???:
    ?????
    ???(??):
    ?????;???-4-(?????)?????????
    ???:
    Tranexamic acid
    ???(??):
    AMCA;HAKU;dv-79;amcha;exacyl;tamcha;tranex;ugurol;LGB TA;amstat
    CBNumber:
    CB1117189
    ???:
    C8H15NO2
    ??? ??:
    157.21
    MOL ??:
    1197-18-8.mol

    ????? ??

    ???
    >300 °C (lit.)
    ?? ?
    281.88°C (rough estimate)
    ??
    1.0806 (rough estimate)
    ???
    1.4186 (estimate)
    ?? ??
    2-8°C
    ???
    Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
    ??? ??
    Crystalline Powder
    ?? ?? (pKa)
    pKa 4.3 (Uncertain);10.6 (Uncertain)
    ??
    White
    ???
    1g/6ml
    Merck
    14,9569
    BRN
    2207452
    InChIKey
    GYDJEQRTZSCIOI-LJGSYFOKSA-N
    CAS ??????
    1197-18-8
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xi
    ?? ???? ?? 36/37/38
    ????? 26-36-37/39
    WGK ?? 2
    RTECS ?? GU8400000
    ?? ?? IRRITANT
    HS ?? 29224999
    ?? LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)
    ???? ?? KE-01455
    ????(GHS):
    ?? ?: Warning
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
    H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
    H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
    ??????:
    P261 ??·?·??·???·??·...·????? ??? ????.
    P264 ?? ??? ?? ??? ????.
    P264 ?? ??? ?? ??? ????.
    P280 ????/???/???/?????? ?????.
    P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
    P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
    P405 ???? ?????.

    ????? MSDS


    Amstat

    ????? C??? ??, ??, ??

    ??? ??

    White or almost white, crystalline powder.

    Originator

    Anvitoff,Knoll,W. Germany,1967

    ??

    Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.

    ??

    Used as lysine analogue to characterize binding sites in plasminogen

    ??

    Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.

    Manufacturing Process

    In an autoclave, 2 grams of a mixture of cis- and trans-4- aminomethylcyclohexane-1-carboxylic acid, which is obtained by catalytic reduction of p-aminomethylbenzoic acid in the presence of platinum catalyst and contains 60% by weight of cis-isomer was reacted at 200°C, for 8 hours with 20 ml of ethyl alcohol in which 0.44 gram of sodium metal had been dissolved. After cooling, the reaction solution was concentrated under a reduced pressure to give a white residue. This residue was dissolved in 40 ml of water and passed through a column of a strongly acidic cation ion_x0002_exchanger resin (NH4+). The eluate was concentrated under reduced pressure to form a white mass. An adequate amount of acetone was added thereto and 1.95 grams of white powder was obtained. This powder was recrystallized from water-acetone to give 1.85 grams (yield, 92.5%) of white crystalline powder having a melting point of 380° to 390°C (decomposition). This product was identified as trans-4-aminomethylcyclohexane-1-carboxylic acid by means of infrared spectrum.

    Therapeutic Function

    Coagulant

    ?? ??

    Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

    Mechanism of action

    Tranexamic acid can also be viewed as a structural analog of lysine. It is presumed that it works by the same mechanism as aminocaproic acid; however, it is 6–10 times more active. It inhibits action of a plasmin and plasminogen inhibitor, and has a hemostatic effect.

    Chemical Synthesis

    Tranexamic acid, trans-4-(aminomethyl)cyclohexane carboxylic acid (24.4.5), is synthesized from 4-methylbenzonitrile. Oxidation of the methyl group gives the mononitrile of terephthalic acid 24.4.2. The cyano group in this compound is reduced by hydrogen using Raney nickel as a catalyst. The benzene ring of the resulting 4- aminomethylbenzoic acid (24.4.3) is reduced to a cyclohexane moiety by hydrogen and a platinum catalyst, which forms an isomeric mixture of 4-aminomethylcyclohexane carboxylic acids (24.4.4), and the desired trans-isomer 24.4.5 is isolated by crystallization of the mixture of its sodium salts.

    ????? ?? ?? ? ???

    ???

    ?? ??


    ????? ?? ??

    ???( 611)?? ??
    ??? ?? ?? ??? ?? ?? ? ??
    Jinan Jianfeng Chemical Co., Ltd
    15562555968
    0531-88113608 info@pharmachemm.com CHINA 200 58
    Cangzhou Wanyou New Material Technology Co.,Ltd
    18631714998
    sales@czwytech.com CHINA 914 58
    Jinan Chenghui-Shuangda Chemical Co.,Ltd
    +86-531-58897082
    +86-531-58897093 ericqiao@jnchsd.com CHINA 158 58
    CHANGZHOU FLUORIDE CHEMICAL CO.,LTD
    15995021858 15995021858
    info@fluoridechem.com CHINA 107 58
    Hebei Yime New Material Technology Co., Ltd.
    +8617703311139
    admin@china-yime.com China 278 58
    Baoji Guokang Bio-Technology Co., Ltd.
    09173909592
    09173909592 cngksw@aliyun.com CHINA 9433 58
    Baoji Guokang Healthchem co.,ltd
    09178656283
    cngksw@aliyun.com CHINA 9466 58
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com China 22607 55
    ZhenYiBio Technology Inc
    +8615309206328
    86-029-89189705 alexxue@zhenyibio.com China 299 58
    Capot Chemical Co.,Ltd.
    +86(0)13336195806 +86-571-85586718
    +86-571-85864795 sales@capotchem.com China 20012 60

    ????? ?? ??:

    Copyright 2019 ? ChemicalBook. All rights reserved