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    Bilobalide

    Bilobalide ??? ???
    ?? ??:
    33570-04-6
    ???:
    Bilobalide
    ???(??):
    BILOBALID;BILOBALIDE;VITEXICARPIM;Bilobalide A;(-)-BILOBALIDE;BILOBALIDE(SH);Bilobalide >BILOBALIDE(AHP);Bilobalide USP/EP/BP;Bilobalide 33570-04-6
    CBNumber:
    CB1688713
    ???:
    C15H18O8
    ??? ??:
    326.3
    MOL ??:
    33570-04-6.mol

    Bilobalide ??

    ???
    >300°
    ??
    57820 -64.3° (c = 2 in acetone)
    ?? ?
    651.7±55.0 °C(Predicted)
    ??
    1.56±0.1 g/cm3(Predicted)
    ?? ??
    −20°C
    ?? ?? (pKa)
    11.74±0.40(Predicted)
    ??? ??
    neat
    Merck
    14,1220
    CAS ??????
    33570-04-6(CAS DataBase Reference)

    ??

    ????? 24/25
    WGK ?? 3
    RTECS ?? LV1665000
    F ?????? 10
    HS ?? 29322090

    Bilobalide C??? ??, ??, ??

    ??

    Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.

    ??

    ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.

    ?? ???

    This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.

    Bilobalide ?? ?? ? ???

    ???

    ?? ??


    Bilobalide ?? ??

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