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    Cilnidipine

    Cilnidipine ??? ???
    ?? ??:
    132203-70-4
    ???:
    Cilnidipine
    ???(??):
    CiL;ATELEC;SISCARD;CINALONG;FRC-8653;Sidipine;FRG 8653;nidipine;ilnidipine;CILNDIPINE
    CBNumber:
    CB2193117
    ???:
    C27H28N2O7
    ??? ??:
    492.52
    MOL ??:
    132203-70-4.mol

    Cilnidipine ??

    ???
    97-99°C
    ?? ?
    652.6±55.0 °C(Predicted)
    ??
    1.240±0.06 g/cm3(Predicted)
    ?? ??
    Keep in dark place,Sealed in dry,Room Temperature
    ???
    H2O: ≤2mg/mL
    ??? ??
    powder
    ?? ?? (pKa)
    2.61±0.70(Predicted)
    ??
    light yellow
    Merck
    14,2275
    InChIKey
    KJEBULYHNRNJTE-DHZHZOJOSA-N
    CAS ??????
    132203-70-4(CAS DataBase Reference)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xi
    ?? ???? ?? 41
    ????? 26-39
    WGK ?? 3
    RTECS ?? US7975550
    HS ?? 29333990
    ?? LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)
    ????(GHS):
    ?? ?: Danger
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? P280, P305+P351+P338, P310
    ??????:
    P280 ????/???/???/?????? ?????.
    P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

    Cilnidipine MSDS


    Cilnidipine

    Cilnidipine C??? ??, ??, ??

    ??

    Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.

    ??? ??

    Yellow Crystalline Solid

    Originator

    Fujirebio (Japan)

    ??

    A dihydropyridine calcium channel blocker

    ??

    antihypertensive;dihydropyridine calcium channel blocker

    ??

    ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.

    ???

    Cinalong;Siscard;Atelec

    ???? ??

    Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

    Cilnidipine ?? ?? ? ???

    ???

    ?? ??


    Cilnidipine ?? ??

    ???( 295)?? ??
    ??? ?? ?? ??? ?? ?? ? ??
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    Cilnidipine ?? ??:

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