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    10-Gingerol

    10-Gingerol ??? ???
    ?? ??:
    23513-15-7
    ???:
    10-Gingerol
    ???(??):
    10-GINGEROL;GINGEROL, 10-;10-Gingerol ,98%;10-GINGEROL, HPLC 98%;(+)-(S)-[10]-Gingerol;10-Gingerol USP/EP/BP;[10]-Gingerol Standard;10]-Gingerol >=95% (HPLC);10-Gingerol, 98%, from Zingiber officinale Roscoe;5-hydroxy-1-(4-hydroxy-3-Methoxyphenyl)tetradecan-3-one
    CBNumber:
    CB6399377
    ???:
    C21H34O4
    ??? ??:
    350.49
    MOL ??:
    23513-15-7.mol

    10-Gingerol ??

    ???
    56-58 °C
    ?? ?
    499.7±35.0 °C(Predicted)
    ??
    1.037±0.06 g/cm3(Predicted)
    ???
    166℃
    ?? ??
    2-8°C
    ???
    methanol: soluble5mg/mL, clear, colorless
    ?? ?? (pKa)
    10.02±0.20(Predicted)
    ??? ??
    neat
    InChIKey
    AIULWNKTYPZYAN-SFHVURJKSA-N
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ?? ???? ?? 53
    ????? 24/25
    WGK ?? 3
    HS ?? 29145019
    ????(GHS):
    ?? ?:
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H413 ??? ??? ?? ????? ??? ??? ?? ?? ????? ?? - ?? ?? 4
    ??????:

    10-Gingerol C??? ??, ??, ??

    ??

    10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH (Item No. 14805), superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.

    ??

    (+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.

    Biochem/physiol Actions

    [10]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.

    10-Gingerol ?? ?? ? ???

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    10-Gingerol ?? ??

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