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    ??? ???

    ??? ???
    ??? ??? ??? ???
    ?? ??:
    481-72-1
    ???:
    ??? ???
    ???(??):
    ??? ???
    ???:
    Aloe emodin
    ???(??):
    RHA;C:C&B63;NSC 38628;Aloe-eModol;ALOE-EMODIN;rhabarberone;ALOE-EMODINE;RHUBARBERONE;ALLYLPYRUVATE;ALOE EMODIN(RG)
    CBNumber:
    CB6727767
    ???:
    C15H10O5
    ??? ??:
    270.24
    MOL ??:
    481-72-1.mol

    ??? ??? ??

    ???
    223-224°C
    ?? ?
    373.35°C (rough estimate)
    ??
    1.3280 (rough estimate)
    ???
    1.5000 (estimate)
    ?? ??
    2-8°C
    ?? ?? (pKa)
    6.30±0.20(Predicted)
    ??? ??
    neat
    Merck
    14,306
    BRN
    2059062
    ???
    Hygroscopic
    InChIKey
    YDQWDHRMZQUTBA-UHFFFAOYSA-N
    CAS ??????
    481-72-1(CAS DataBase Reference)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xi
    ?? ???? ?? 36/37/38
    ????? 26-36
    WGK ?? 3
    RTECS ?? CB6712200
    F ?????? 10
    HS ?? 29146990
    ????(GHS):
    ?? ?: Warning
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
    H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
    H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
    ??????:
    P261 ??·?·??·???·??·...·????? ??? ????.
    P264 ?? ??? ?? ??? ????.
    P264 ?? ??? ?? ??? ????.
    P280 ????/???/???/?????? ?????.
    P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

    ??? ??? C??? ??, ??, ??

    ??? ??

    Orange Solid

    ??

    Shows significant inhibitory activity against the P-388 leukemia in mice when administered as a suspension in acetone-Tween 80. Has a specific in vitro and in vivo antineuroectodermal tumor activity. Cathartic.

    ??

    ChEBI: A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.

    ?? ??

    Diacerein is known to be a suitable drug to treat osteoarthritis and prevent vascular diseases. It is a semi-synthetic anthraquinone derivative which acts by inhibiting the production of interleukin-1 and secretion of metalloproteases.

    Biochem/physiol Actions

    Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

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