• ChemicalBook
    Chinese English Japanese Germany Korea

    ????

    ????
    ???? ??? ???
    ?? ??:
    77-52-1
    ???:
    ????
    ???(??):
    ????;???????
    ???:
    Ursolic acid
    ???(??):
    MALOL;URSON;UrsoL;PRUNOL;Ursolic;NSC-4060;Masterin;Merotaine;Neoage UR;MICROMEROL
    CBNumber:
    CB7470516
    ???:
    C30H48O3
    ??? ??:
    456.71
    MOL ??:
    77-52-1.mol

    ???? ??

    ???
    292 °C (dec.) (lit.)
    ??
    59 º (c=0.3, pyridine)
    ?? ?
    502.79°C (rough estimate)
    ??
    1.0261 (rough estimate)
    ???
    1.4940 (estimate)
    ?? ??
    2-8°C
    ?? ?? (pKa)
    4.68±0.70(Predicted)
    ??? ??
    Crystalline Powder or Needles
    ??
    White to off-white
    ???
    insoluble
    Merck
    14,9890
    BRN
    2228563
    CAS ??????
    77-52-1(CAS DataBase Reference)
    EPA
    Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)- (77-52-1)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xi
    ?? ???? ?? 36/37/38
    ????? 24/25-36-26
    WGK ?? -
    RTECS ?? YU9520000
    F ?????? 10-23
    HS ?? 29181990
    ?? ?? ??? 77-52-1(Hazardous Substances Data)
    ????(GHS):
    ?? ?:
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H413 ??? ??? ?? ????? ??? ??? ?? ?? ????? ?? - ?? ?? 4
    ??????:

    ???? C??? ??, ??, ??

    ??? ??

    white to light yellow crystal powde

    ??

    A Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.

    ??

    ursolic acid helps maintain the look and feel of the skin, acts as a perfume and helps mask odor. Therapeutic benefits in skin care include anti-inflammatory activity. ursolic acid has demonstrated anti-microbial, anti-bacterial, and anti-fungal action as well.

    ??

    ChEBI: A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.

    Anticancer Research

    It is a triterpenoid, derived from basil, and suppresses the activation of NF-κB byinhibiting a kinase that activates NF-κB(IKK) (Aggarwal and Shishodia 2004). It suppresses tumorigenesis, tumor promotion, and angiogenesis by downregulationof the expression of lipoxygenases (LOX), MMP-9, and COX-2. It is reported toinduce apoptosis in breast cancer, melanoma, hepatoma, prostate cancer, andacute myelogenous leukemia by preventing replication of DNA, inhibition of proteintyrosine kinases, activation of caspases, induction of calcium release, anddownregulating apoptosis gene cellular inhibitor. Ursolic acid inhibits IκBαkinase activity, degradation of IκBα, phosphorylation, NF-κB-dependent reportergene expression, p65 nuclear translocation, and p65 phosphorylation. Inhibitionof NF-κB leads to the reduction of cyclin D1, COX-2, and MMP9 expression.This downregulates STAT-3 activation and its regulated gene products such ascyclin D1, Mcl-1, Bcl-xL, survivin, Bcl-2, and VEGF. It also induces the expressionof tyrosine phosphatase SHP-1 protein and of mRNA (Aggarwal et al. 2008;Hsu et al. 2004).

    Cytotoxicity

    IC50 (μg/mL): 6.7 (518A2), 5.3 (A2780), 7(A549), 6.4 (FaDu), 4.8 (HT29), 5.8(MCF-7), 8.5 (NIH3T3) (Wiemann et al.2016)
    IC50 (μg/mL): 12.38 (MGC-803),17.12(HCT-116), 13.39 (T24), 13.81(HepG2), 16.36 (A549), >45.7 (HL-7702)(Hua et al. 2015).

    ???? ?? ?? ? ???

    ???

    ?? ??


    ???? ?? ??

    ???( 515)?? ??
    ??? ?? ?? ??? ?? ?? ? ??
    Shaanxi Pioneer Biotech Co., Ltd .
    86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
    029-84385017 sales@pioneerbiotech.com CHINA 3001 58
    Hebei Guanlang Biotechnology Co., Ltd.
    +8619930503282
    sales3@crovellbio.com China 5892 58
    Aktin Chemicals, Inc.
    028-85159085
    86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
    Pharmyao, All for life--- A Specific Trading Platform For Reference Standard Material
    13560473592 020-81716320
    020-81716319 sales@pharmyao.com CHINA 173 58
    Henan Tianfu Chemical Co.,Ltd.
    0371-55170693
    0371-55170693 info@tianfuchem.com CHINA 22607 55
    Hangzhou FandaChem Co.,Ltd.
    008615858145714
    +86-571-56059825 fandachem@gmail.com CHINA 8909 55
    Nanjing Finetech Chemical Co., Ltd.
    025-85710122 17714198479
    025-85710122 sales@fine-chemtech.com CHINA 890 55
    Hefei TNJ Chemical Industry Co.,Ltd.
    +86-0551-65418679
    86-0551-65418697 info@tnjchem.com China 3000 55
    Shanxi Naipu Import and Export Co.,Ltd
    +8613734021967
    kaia@neputrading.com CHINA 1009 58
    Shanghai Zheyan Biotech Co., Ltd.
    18017610038
    zheyansh@163.com CHINA 3623 58

    ???? ?? ??:

    Copyright 2019 ? ChemicalBook. All rights reserved