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    120-51-4
    ???:
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    ???(??):
    ???????;?????;??????;?????;?? ?????
    ???:
    Benzyl benzoate
    ???(??):
    BJSBZ;Zylate;ASCABIN;Scabide;Benylate;ASCABIOL;Colebenz;Scabagen;Scabanca;Scabitox
    CBNumber:
    CB9152283
    ???:
    C14H12O2
    ??? ??:
    212.24
    MOL ??:
    120-51-4.mol

    ??????? ??

    ???
    17-20 °C (lit.)
    ?? ?
    323-324 °C (lit.)
    ??
    1.118 g/mL at 20 °C (lit.)
    ???
    1 mm Hg ( 125 °C)
    ???
    n20/D 1.568(lit.)
    FEMA
    2138 | BENZYL BENZOATE
    FEMA
    2797 | OCTANAL
    ???
    298 °F
    ?? ??
    2-8°C
    ???
    Miscible with ethanol, alcohol, chloroform, ether, oils.
    ??? ??
    Liquid
    ??
    Clear colorless
    ???
    practically insoluble
    JECFA Number
    24
    Merck
    14,1127
    BRN
    2049280
    ???
    Stable. Substances to be avoided include strong oxidizing agents. Combustible.
    InChIKey
    SESFRYSPDFLNCH-UHFFFAOYSA-N
    CAS ??????
    120-51-4(CAS DataBase Reference)
    NIST
    Benzyl Benzoate(120-51-4)
    EPA
    Benzyl benzoate (120-51-4)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xn,N
    ?? ???? ?? 22-51/53
    ????? 25-61-46
    ????(UN No.) UN 3082 9 / PGIII
    WGK ?? 2
    RTECS ?? DG4200000
    ?? ?? ?? 896 °F
    TSCA Yes
    ?? ?? 9
    HS ?? 29163100
    ?? ?? ??? 120-51-4(Hazardous Substances Data)
    ?? LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)
    ???? ?? KE-02782
    ????(GHS):
    ?? ?: Warning
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
    H401 ????? ??? ?? ????? ?? - ?? ?? 2 P273, P501
    H411 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 2
    ??????:
    P264 ?? ??? ?? ??? ????.
    P264 ?? ??? ?? ??? ????.
    P270 ? ??? ??? ??? ???, ???? ???? ???.
    P273 ???? ???? ???.
    P330 ?? ?????.
    P501 ...? ??? / ??? ?? ???.
    NFPA 704
    1
    0

    ??????? MSDS


    Benzyl benzoate

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    ??? ?? ??? ???? ??????.??? ??? ?? ?? ?? ????? ???? ??, ??? ??? ??? ???. ??? ?? ? (e. g. tuberose, hyacinth)?? ??? ??? ???? balsam? ?? ????.

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    ?? ?? ???? ??? ??? ???, ??? ? ???? ?????. ?? ?? ???? ?? ??? ?? ????, ???? ??? ? ??, ???, ?? ??? ???.?? ?? ??? (BnBzO)? ?? ? ?? ?????. ??? ???? ????? ??? ???? scarcoptes scabiei? ?? ?? ?? ? ?? ???? ?? ???? ??? ?? ? ?????. ??? ?? ??? ?? ?? ??? ??? ?? ??? ? ????. ? ?? ????? ??? ???? ?? ?? ??? ?????? ??? ??? ????. ?? ???? ?? ????? ?? ??? ?? ?????. ?? ?? ???, ????? ???? ??, ??? ? ????? ??? ?? (chiggers), ??? (ticks) ? ?? (mogquitoes)? ?? ???? ??? ? ????.

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    ?? ?? ???? ??? ?? ??? ???? ?? ??? ??? ?? ?? ??? ????. ?? ???, ?? ?? ?? ???? ?? ??? ???? ?? ??? ?? ????.??? ?? ??? ??? ?? ??? ??? ?????.??? ?? ?? ?????? tishchenko ??? ?? ?? ? ???.

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    Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.

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    Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor.
    Benzyl Benzoate
    Benzyl Benzoate is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.

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    Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).

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    Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies , for example as a combination drug of benzyl benzoate/disulfiram.
    It has other uses :
    a fixative in fragrances to improve the stability and other characteristics of the main ingredients
    a food additive in artificial flavors
    a plasticizer in cellulose and other polymers
    a solvent for various chemical reactions
    a treatment for sweet itch in horses
    a treatment for scaly leg mites in chickens.

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    As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.

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    benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.

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    By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.

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    BENZYL BENZOATE is produced by the Cannizzaro reaction from benzaldehyde, by esterifying benzyl alcohol with benzoic acid, or by treating sodium benzoate with benzyl chloride. It is purified by distillation and crystallization. Benzyl benzoate is used as a fixative and solvent for musk in perfumes and flavors, as a plasticizer, miticide, and in some external medications. The compound has been found effective in the treatment of scabies and pediculosis capitis (head lice, Pediculus humanus var. capitis).

    Indications

    Benzyl benzoate: 20% to 25%. This agent is relatively nontoxic and is widely used in developing countries to treat scabies and pediculosis capitis and pubis. Only a veterinary preparation is available in the United States. Benzyl benzoate is synthetically derived from the esterification of benzoic acid with benzyl alcohol. Its mechanism of action is unknown. It is toxic to Sarcoptes scabei and may be toxic to Pediculosis capitis and Phthirus pubis. No resistance has been demonstrated to date.
    Benzyl benzoate can be used in a 5% emulsion to repel many arthropods and can be used as a lotion to treat sarcoptic mange and canine pediculosis.

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    Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop).

    Taste threshold values

    Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.

    Synthesis Reference(s)

    Journal of Heterocyclic Chemistry, 24, p. 187, 1987 DOI: 10.1002/jhet.5570240135
    Tetrahedron Letters, 27, p. 2383, 1986 DOI: 10.1016/S0040-4039(00)84535-9

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    Benzyl benzoate is an aromatic ester that is used as a food flavoring agent. It has been identified as one of the main volatile aroma component of cranberry, mango and Egyptian Jasminum sambac flowers.

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    Irritant to eyes, skin.

    Pharmaceutical Applications

    Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
    However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
    Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.

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    Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.

    Biochem/physiol Actions

    Benzyl benzoate is the condensation product of benzoic acid and benzyl alcohol. It is utilized for treating human scabies as well as kills house dust mite.

    Clinical Use

    Benzyl benzoate is a naturally occurring ester obtained fromPeru balsam and other resins. It is also prepared syntheticallyfrom benzyl alcohol and benzoyl chloride. The ester isa clear colorless liquid with a faint aromatic odor. It is insolublein water but soluble in organic solvents.
    Benzyl benzoate is an effective scabicide when appliedtopically. Immediate relief from itching probably resultsfrom a local anesthetic effect; however, a complete cureis frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized withtriethanolamine. This preparation has the additionaladvantage of being essentially odorless, nonstaining, andnonirritating to the skin. It is applied topically as a lotionover the entire dampened body, except the face.

    Safety

    Benzyl benzoate is metabolized by rapid hydrolysis to benzoic acid and benzyl alcohol. Benzyl alcohol is then further metabolized to hippuric acid, which is excreted in the urine.
    Benzyl benzoate is widely used as a 25% v/v topical application in the treatment of scabies and as an excipient in intramuscular injections and oral products. Adverse reactions to benzyl benzoate include skin irritation and hypersensitivity reactions. Oral ingestion may cause harmful stimulation of the CNS and convulsions. Benzyl benzoate should be avoided by perople with perfume allergy.
    LD50 (cat, oral): 2.24 g/kg
    LD50 (dog, oral): 22.44 g/kg
    LD50 (guinea pig, oral): 1.0 g/kg
    LD50 (mouse, oral): 1.4 g/kg
    LD50 (rabbit, oral): 1.68 g/kg
    LD50 (rabbit, skin): 4.0 g/kg
    LD50 (rat, oral): 0.5 g/kg
    LD50 (rat, skin): 4.0 g/kg

    Chemical Synthesis

    This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.

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    Benzyl benzoate acts as a local irritant. At high levels of exposure, free benzoic acid may sequester significant amounts of acetyl coenzyme A (CoA), which could disrupt cholinergic signaling. Recent findings suggest that benzyl benzoate may have estrogenic properties.

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    Benzyl benzoate, a relatively non-toxic liquid widely used for the treatment of scabies, is converted into benzoic acid in vivo (Williams, 1959).

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    Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided.

    Toxicity evaluation

    Acute oral LD50 for rats: 1,700 mg/kg

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    Benzyl benzoate is incompatible with alkalis and oxidizing agents.

    Regulatory Status

    Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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