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    ???????

    ???????
    ??????? ??? ???
    ?? ??:
    527-07-1
    ???:
    ???????
    ???(??):
    D-????,??????;D-????????;PMP????????;????,????;????,??????;????,??????,D-;???????;????????;???D-?????;??????????;??????;D-???????;????????;???????;2,3,4,5,6-??????? ??? ? ??? ?;D-??? ?, ????? ?;D-???? ???;PMP ??? ?????;???;??? ?, ??? ?
    ???:
    Sodium gluconate
    ???(??):
    glonsen;pasexon100t;BVD Addicrete;Sunmorl N 60S;Disparlight DV;Developer,partB;Natriumgluconat;gluconatodisodio;SODIUM GLUCONATE;SOIDUMD-GLUCONATE
    CBNumber:
    CB9229989
    ???:
    C6H13NaO7
    ??? ??:
    220.15
    MOL ??:
    527-07-1.mol

    ??????? ??

    ???
    170-175 °C
    ??
    [α]D20 +11~+13° (c=10, H2O)
    ?? ??
    Store below +30°C.
    ???
    H2O: 0.1 g/mL, clear
    ??? ??
    Crystalline Powder
    ??
    White to light beige
    ??????(pH)
    7.0-8.0 (100g/l, H2O, 20℃)
    ???
    Very soluble in water; sparingly soluble in alcohol; insoluble in ether.
    Merck
    14,4456
    BRN
    3919651
    ???
    Stable. Incompatible with strong oxidizing agents.
    CAS ??????
    527-07-1(CAS DataBase Reference)
    EPA
    Sodium gluconate (527-07-1)

    ??

    ????? 24/25
    WGK ?? 1
    RTECS ?? LZ5235000
    ?? ?? ?? >200 °C
    TSCA Yes
    HS ?? 29181600
    ?? LD50 orally in Rabbit: > 2000 mg/kg
    ???? ?? KE-17676

    ??????? C??? ??, ??, ??

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    white or off-white granular powder

    Originator

    Sodium gluconate,JUNGBUNZLAUER INC.

    ??

    electrolyte replenisher

    ??

    Sodium gluconate has been used as a component of recording buffer used in two-electrode voltage-clamp (TEVC) recording in Xenopus laevis oocytes. It has also been used as a control for sodium.

    ??

    ChEBI: An organic sodium salt having D-gluconate as the counterion.

    Manufacturing Process

    D-Gluconic acid was prepared by fermentation of glucose with Aspergillus niger CCM 8004 at 30°C. The fermentation medium contained 150 g/dm-3 glucose, 0.59 g/dm-3 ammonium sulfate, 0.25 g/dm-3 potassium chloride, 0.25 g/dm-3 potassium dihydrophosphate, 0.25 g/dm-3 MgSO4·7H2O, 1.0 g/dm-3 Ca(NO3)2·4H2O, and 1.5 g/dm-3 of a 50% corn-steep liquor. The pH of the culture was maintained at the value of 6.5 during the growth phase and 5.5 (maximum glucose oxidase activity) during the production phase by addition of 11.7 M sodium hydroxide solution. Gluconic acid concentration was determined by HPLC analysis. By neutralization of D-gluconic acid with sodium hydroxide was obtained monosodium D-gluconate.

    Therapeutic Function

    Electrolyte replenisher

    Biochem/physiol Actions

    Ingestion of sodium gluconate is known to stimulate the production of intestinal butyrate. It is widely used in food, pharmaceutical paper and textile industry. It acts as a chelating agent. Sodium gluconate serves as a detergent in bottle washing formulation.

    Safety Profile

    Low toxicity by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes

    Purification Methods

    Crystallise it from a small volume of H2O (solubility is 59g/100mL at 25o), or dissolve it in H2O and add EtOH since it is sparingly soluble in EtOH. It is insoluble in Et2O. It forms a Cu complex in alkaline solution and a complex with Fe in neutral solution. [cf p 639, Sawyer & Bagger J Am Chem Soc 81 5302 1959, Beilstein 3 I 188.]

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