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    2-?????-4-???????

    2-?????-4-???????
    2-?????-4-??????? ??? ???
    ?? ??:
    131-57-7
    ???:
    2-?????-4-???????
    ???(??):
    1-????-4-???????;2-?????-4-???????;2-????-4-???????;????-3;(2-?????-4-?????)-?????;????
    ???:
    Oxybenzone
    ???(??):
    MOD;uf3;HMB;Uf 3;Uv 9;BP-3;HMBP;Anuvex;uvinul9;LGB-BP3
    CBNumber:
    CB9276251
    ???:
    C14H12O3
    ??? ??:
    228.24
    MOL ??:
    131-57-7.mol

    2-?????-4-??????? ??

    ???
    62-64 °C(lit.)
    ?? ?
    150-160 °C5 mm Hg(lit.)
    ??
    1,3 g/cm3
    ???
    1.5805 (estimate)
    ???
    216°C
    ?? ??
    2-8°C
    ???
    95% ethanol: soluble50mg/mL, clear, colorless
    ?? ?? (pKa)
    7.56±0.35(Predicted)
    ??? ??
    Crystalline Powder
    ??
    White to light yellow
    ???
    <0.1 g/100 mL at 20 ºC
    Merck
    14,6954
    BRN
    1913145
    InChIKey
    DXGLGDHPHMLXJC-UHFFFAOYSA-N
    CAS ??????
    131-57-7(CAS DataBase Reference)
    NIST
    Oxybenzone(131-57-7)
    EPA
    2-Hydroxy-4-methoxybenzophenone (131-57-7)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xi
    ?? ???? ?? 36/37/38
    ????? 26-36-37
    ????(UN No.) UN 3077 9/PG III
    WGK ?? 2
    RTECS ?? DJ1575000
    TSCA Yes
    ?? ?? 9
    ???? III
    HS ?? 29145000
    ?? ?? ??? 131-57-7(Hazardous Substances Data)
    ?? LD50 orally in rats: >12.8 g/kg (Lewerenz)
    ???? ?? KE-20627
    ????(GHS):
    ?? ?: Warning
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
    H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
    H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
    ??????:
    P261 ??·?·??·???·??·...·????? ??? ????.
    P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
    P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
    P405 ???? ?????.

    2-?????-4-??????? MSDS


    2-Hydroxy-4-methoxybenzophenone

    2-?????-4-??????? C??? ??, ??, ??

    ??? ??

    white to light yellow crystalline powder

    ??

    ultraviolet screen

    ??

    Oxybenzone is an organic compound used in sunscreens. Oxybenzone is used as an ingredient in sunscreen and other cosmetics because it absorbs UVB and short-wave UVA (ultraviolet) rays. Oxybenzone was one of the first compounds incorporated into sunscreen formulations to offer enhanced UVA protection because its absorption spectrum extends to less than 350 nm.

    ??

    Sunscreen. UV stabilizer

    ??

    Ultraviolet light absorber and stabilizer, especially in plastics and paints.

    ??

    oxybenzone (benzophenone-3) is the drug name for an FDAapproved uV filter and absorber.

    ??

    benzophenone-3 (oxybenzone) is an oil-soluble uV absorber and filter with absorption rates within the uVA and uVB peak ranges. It has an approved usage level of up to 6 percent in the united States and 10 percent in the european union. Benzophenone-3 enhances SPF and is popular among sunscreen formulators given a concern over potential safety problems associated with more traditional sunscreen chemicals. However, some reports associate it with causing photocontact allergy. It is considered a non-comedogenic raw material.

    ?? ??

    Preparation by partial methylation of 2,4- dihydroxy-benzophenone,
    ? with methyl iodide in the presence of sodium hydroxide;
    ? with a methyl halide;
    ? with dimethyl sulfate in the presence of sodium hydroxide or alkaline solution.

    ??

    ChEBI: A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.

    ???

    Uvinul M40 (BASF).

    Synthesis Reference(s)

    Tetrahedron, 42, p. 885, 1986 DOI: 10.1016/S0040-4020(01)87495-0

    ?? ??

    White to off-white or light yellow powder.

    ??? ?? ??

    Insoluble in water.

    ????

    Flash point data for Oxybenzone are not available; however, Oxybenzone is probably combustible.

    ?? ?? ??

    BZP-3 is used as a direct sunscreen agent and in antiaging creams. Allergic reactions have been reported. Cross-reactivity is expected in an average of one in four patients photoallergic to ketoprofen.

    Safety Profile

    Poison by intraperitoneal route. Mddly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

    2-?????-4-??????? ?? ?? ? ???

    ???

    ?? ??


    2-?????-4-??????? ?? ??

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