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    118-55-8
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    ???(??):
    ??????;??????;????????;2-????????;2-??????? ? ?? ???;?? ?, 2-?????-, ?? ???;??;??? ?, ?? ???;?? ????;?? 2-????????;?? ????
    ???:
    Phenyl salicylate
    ???(??):
    SALOL;Musol;FEMA 3960;Salphenyl;Seesorb 201;'LGC' (2411);'LGC' (2613);Phenyl salicy;Seesorb K 201;AURORA KA-3673
    CBNumber:
    CB9322550
    ???:
    C13H10O3
    ??? ??:
    214.22
    MOL ??:
    118-55-8.mol

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    41-43 °C (lit.)
    ?? ?
    172-173 °C/12 mmHg (lit.)
    ??
    1.250g/cm3
    FEMA
    3960 | PHENYL SALICYLATE
    ???
    1.5090 (estimate)
    ???
    >230 °F
    ?? ??
    2-8°C
    ???
    dioxane: 0.1 g/mL, clear, colorless
    ?? ?? (pKa)
    8.71±0.10(Predicted)
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    Fine Crystalline Powder
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    White
    ???
    Soluble in alcohol, ether, chloroform, turpentine, acetone and benzene. Sparingly soluble in chloroformbenzene. Insoluble in water.
    Merck
    14,7310
    JECFA Number
    736
    BRN
    393969
    ???
    Light sensitive. Incompatible with strong oxidants. Flammable.
    CAS ??????
    118-55-8(CAS DataBase Reference)
    NIST
    Benzoic acid, 2-hydroxy-, phenyl ester(118-55-8)
    EPA
    Phenyl salicylate (118-55-8)
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    • ?? ? ???? ?? (GHS)
    ??? ?? Xi
    ?? ???? ?? 36/37/38
    ????? 26-36-24/25
    ????(UN No.) UN 3077 9 / PGIII
    WGK ?? 2
    RTECS ?? VO6125000
    TSCA Yes
    HS ?? 29182300
    ???? ?? KE-30839
    ????(GHS):
    ?? ?: Warning
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H303 ??? ??? ? ?? ?? ?? ?? - ?? ?? 5 P312
    H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
    H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
    H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
    ??????:
    P261 ??·?·??·???·??·...·????? ??? ????.
    P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
    P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
    P405 ???? ?????.
    NFPA 704
    1
    2 0

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    Disperse Dye Blue EXSF

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    white crystalline solid with an aromatic odour

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    Phenyl salicylate has a distinctive aromatic odor and taste.

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    Has apparently not been reported to occur in nature.

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    Phenyl salicylate is used as an analgesic and antipyretic. It is also used in the manufacture of polymer plastics, lacquers, waxes, polishes, adhesives, and sunscreen products. It is also a fragrance ingredient, but has limited use.

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    In the manufacture of various polymers for the plastics industry, also in lacquers, adhesives, waxes, polishes. In suntan oils and cremes. As light absorber to prevent discoloration of plastics. Has some plasticizer properties.

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    Phenyl salicylate is used as analgesie; antipyretie; anti-rheumatie agent; manufacture of polymer plastics, lacquers, waxes, polishes, and adhesives; in suntan oils and creams; light absorber to prevent discoloration of plastics; in veterinary use as an external disinfectant and intestinal antiseptic agent.

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    ChEBI: A benzoate ester that is the phenyl ester of salicylic acid. Also known as salol, it can be formed by heating salicylic acid with phenol and is used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes.

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    By the action of phosphorus oxychloride on a mixture of phenol and salicylic acid (Merck Index, 1968).

    Toxicity evaluation

    The acute oral LD50 value in rats was reported as 3 g/kg and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Levenstein, 1975). The probable LD in man is 50-500 mg/kg. The toxic effects of phenyl salicylate are similar to those of phenol but do not include a corrosive action on the alimentary canal (Dittmer, 1959).

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    White crystals. Insoluble in water.

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    Insoluble in water.

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    Incompatible with bromine water, ferric salts, camphor, phenol, chloral hydrate, monobrominated camphor, thymol, or urethane in trituration. .

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    Flash point data for Phenyl salicylate are not available, however Phenyl salicylate is probably combustible.

    Pharmacology

    Phenyl salicylate was found to have slight analgesic activity against pain stimuli in mice (Kameyama, 1961), but ip administration of 500 mg/kg showed no analgesic action against an electric shock applied to the tails of mice (McKenzie & Beechey, 1962). In vitro studies on cartilage and rat-liver mitochondria have shown that phenyl salicylates are more active than salicylates in uncoupling oxidative phosphorylation (Bostrom, Berntsen & Whitehouse, 1964).

    Safety Profile

    Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS

    Chemical Synthesis

    Prepared by a synthetic process whereby the phenol group is made to unite with the salicylic acid radical. Also obtained by heating salicylic acid, the air being excluded.

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    According to Baas (1890) from 44 to 96% of a dose (5-8 g) of phenyl salicylate is hydrolysed in man and none of it is found in the faeces. An increase in the ethereal sulphates of the urine after its ingestion is due, no doubt, to the phenol liberated (Williams, 1959). Phenyl salicylate is hydrolysed in the gut primarily to phenol and salicylic acid, which are rapidly absorbed and excreted (Fassett, 1963), but it was not hydrolysed by a partially purified preparation of acetylarylesterase from human plasma (Augustinsson & Ekedahl, 1962). Intestinal absorption and excretion of orally administered phenyl salicylate were studied in rabbits and dogs by analysis of blood and urine samples; oral administration of glucosamine hydrochloride increased the blood concentration of phenyl salicylate but had little effect on urinary excretion (Tanaka, Kojima & Matsubara, 1961).

    Purification Methods

    Fractionally crystallise salol from its melt, then crystallise it from *benzene. [Beilstein 10 IV 154.]

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