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    ?? ??:
    122-52-1
    ???:
    ???? ????
    ???(??):
    ??????????;???????;???(???)???;????????;????????;?????????;???????,????????;????????;????? ?????;????? ????;????? ? ????? ???
    ???:
    Triethyl phosphite
    ???(??):
    P(EtO)3;P(OEt)3;triethyl;(C2H5O)3P;AURORA KA-1231;Phosphorus ether;Triethylphosphit;TriethyPhosphite;TRIETHYLPHOSPHILE;Triethoxyphosphine
    CBNumber:
    CB9702666
    ???:
    C6H15O3P
    ??? ??:
    166.16
    MOL ??:
    122-52-1.mol

    ???? ???? ??

    ???
    -112°C
    ?? ?
    65 °C
    ??
    0.969 g/mL at 25 °C(lit.)
    ???
    <6 hPa (20 °C)
    ???
    n20/D 1.413(lit.)
    ???
    130 °F
    ?? ??
    Flammables area
    ??? ??
    liquid
    Specific Gravity
    0.969
    ??
    colorless
    ??
    characteristic, obnoxious, phosphiteodor
    ????
    3.75-42.5%(V)
    ???
    slightly soluble
    Hydrolytic Sensitivity
    7: reacts slowly with moisture/water
    ??
    Air & Moisture Sensitive
    BRN
    956578
    CAS ??????
    122-52-1(CAS DataBase Reference)
    NIST
    Phosphorous acid, triethyl ester(122-52-1)
    EPA
    Triethyl phosphite (122-52-1)
    ??
    • ?? ? ?? ??
    • ?? ? ???? ?? (GHS)
    ??? ?? Xn
    ?? ???? ?? 10-22-36/37/38-20/22
    ????? 16-26-36
    ????(UN No.) UN 2323 3/PG 3
    WGK ?? 1
    RTECS ?? TH1130000
    F ?????? 10-23
    ?? ?? ?? 250 °C
    TSCA Yes
    HS ?? 2920 24 00
    ?? ?? 3
    ???? III
    ?? ?? ??? 122-52-1(Hazardous Substances Data)
    ?? LD50 orl-rat: 1840 mg/kg JACTDZ 1,218,92
    ???? ?? KE-28705
    ????(GHS):
    ?? ?: Warning
    ??·?? ??:
    ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
    H226 ??? ?? ? ?? ??? ?? ?? 3 ??
    H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
    H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
    H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
    H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? P261, P271, P304+P340, P312
    H402 ????? ??? ?? ????? ?? - ?? ?? 3
    H412 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 3 P273, P501
    ??????:
    P210 ?·???·??·????? ????? - ?? ???.
    P262 ?, ??, ??? ?? ??? ???.
    P273 ???? ???? ???.
    P280 ????/???/???/?????? ?????.
    P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
    P370+P378 ?? ? ?? ?? ?? (Section 5. ??, ??? ????? ??? ???)?(?) ?????.
    NFPA 704
    2
    0 1

    ???? ???? MSDS


    Phosphorous acid triethyl ester

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    ???(MW) 166.1565  ;
    ?? 0.97; ???(°C) 156;
    ???(°C) 52;
    ?? ? ?? ??? ?? ??? ???? ??? ??.

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    ?(P)? ??? ????(????)? ??- ???, ??, ???, ??????.

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    Triethyl phosphite is a clear colorless liquid with a strong foul odor. Insoluble in water; soluble in alcohol and ether. Combustible.Vapors heavier than air.

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    Synthesis, plasticizers, stabilizers, lubricant and grease additives.

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    Triethyl phosphite is an organophosphorus compound. It is used as a reducing agent; can react with electrophiles to form phosphonates or phosphates; forms a stable complex with copper(I) iodide.
    Triethyl phosphite is a very good nucleophile. The carbon adjacent to the bromine is the most electrophilic position, and phosphorus is the only nucleophile. Triethyl phosphite displaces the bromine in an SN2-like process, and back attack by the bromide which is released generates a phosphonate product, in which the α-protons are strongly acidic.

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    Triethyl phosphite is produced in a closed system by reaction of phosphorous trichlorid and ethanol in the presence of an inorganic or organic base. The product is purified by distillation (Bayer AG, 2002a).

    Triethyl phosphite is exclusively used as an intermediate for the manufacturing of different products: flame retardants (about 60 %), optical brighteners (about 15 %), pesticides (about 15 %), antioxidants (about 5 %), and pharmaceuticals (about 5 %).

    ?? ??

    This reaction is currently used for the preparation of synthetically useful phosphonate reagents employed in modified retinal studies. Thus, diethyl 3-alkoxycarbonyl-2-propenylphosphonates are prepared in 72-91% yields by the reaction of methyl or ethyl 4-bromocrotonates with triethyl phosphite at 150-160°C. Similarly, diethyl 3-(ethoxycarbonyl)-2 methyl-2-propenylphosphonate is prepared in 81% yield from triethyl phosphite and ethyl 3-methyl-4-chlorocrotonate by heating at 180- 200°C.The diethyl (E)- and (Z)-3-ethoxycarbonyl-3 fluoro-2 -methyl-2-propenylphosphonates are respectively obtained from triethyl phosphite and (E)- or (Z)-4-bromo-2-fuoro-3-methyl-2-butenoates at 140°C.

    ?? ???

    Triethyl phosphite is colorless, moderately toxic liquid, combustible. Flammable when exposed to heat or flame. When heated to decomposition Triethyl phosphite emits toxic fumes of oxides of phosphorus [Lewis, 3rd ed., 1993, p. 1271].

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    Exposure to high concentrations may cause headache, nausea, and dizziness due to reduced chlolinesterase activity.

    ????

    Special Hazards of Combustion Products: May form hazardous decomposition products.

    Safety Profile

    Moderately toxic by ingestion. A skin and eye irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits toxic fumes of POx.

    Toxicity evaluation

    The acute toxicity after oral, dermal, and inhalation exposure is relatively low. The oral LD50s in rats ranged between 1840 mg/kg bw (females) and 2470 mg/kg bw (males). Symptoms of rapid breathing and tremors were observed prior to death. In mice LD50 values above 3700 mg/kg bw were recorded. The 6-hour inhalation LC50 with an aerosol of 1.6-3.5 μm MMAD in rats was between 11,100 mg/m3 (females) and 11,600 mg/m3 (males). Clinical signs included eye and upper respiratory irritation, salivation and rapid, shallow breathing. The dermal LD50 in rabbits was between 2800 mg/kg bw (males) and > 3000 mg/kg bw (females).

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